FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088579973> ?p ?o ?g. }

• W2088579973 endingPage "1042" @default.
• W2088579973 startingPage "1034" @default.
• W2088579973 abstract "Background: The cellular mechanisms regulating branching and growth of the intersegmental vessels (ISVs) are not well understood. We have carried out studies demonstrating that Hedgehog (Hh) signaling is a major regulator of intersomitic vessel growth. Results: Inhibition of Hh activity by cyclopamine completely blocks formation of intersomitic vessels in the avian embryo. Examination of gene expression patterns in Hh-deficient embryos shows that components of the VEGF and Notch signaling pathways are down-regulated. However, we find no evidence that Notch signaling plays a significant role in regulation of intersomitic vessel growth. Indeed, it appears that Hh modulation of Vascular Endothelial Growth Factor, VEGF, is the primary regulator of growth of intersomitic vessels in the avian embryo. Conclusions: Inhibition of the VEGF pathway results in absence of ISVs, whereas stimulation of VEGF expression leads to precocious branching of ISVs. These results demonstrate that Hh is an essential modulator of VEGF expression during developmental angiogenesis. Developmental Dynamics 241:1034–1042, 2012. © 2012 Wiley Periodicals, Inc." @default.
• W2088579973 created "2016-06-24" @default.
• W2088579973 creator A5025487987 @default.
• W2088579973 creator A5054935753 @default.
• W2088579973 creator A5061893588 @default.
• W2088579973 creator A5075297399 @default.
• W2088579973 date "2012-05-02" @default.
• W2088579973 modified "2023-09-29" @default.
• W2088579973 title "Hedgehog regulates angiogenesis of intersegmental vessels through the VEGF signaling pathway" @default.
• W2088579973 cites W1498587827 @default.
• W2088579973 cites W1844495809 @default.
• W2088579973 cites W1985920188 @default.
• W2088579973 cites W2014483037 @default.
• W2088579973 cites W2017564389 @default.
• W2088579973 cites W2019564264 @default.
• W2088579973 cites W2030196103 @default.
• W2088579973 cites W2042072123 @default.
• W2088579973 cites W2045247659 @default.
• W2088579973 cites W2047346477 @default.
• W2088579973 cites W2056916102 @default.
• W2088579973 cites W2059112286 @default.
• W2088579973 cites W2061623544 @default.
• W2088579973 cites W2062240872 @default.
• W2088579973 cites W2071015683 @default.
• W2088579973 cites W2092684208 @default.
• W2088579973 cites W2093498435 @default.
• W2088579973 cites W2094522867 @default.
• W2088579973 cites W2095485537 @default.
• W2088579973 cites W2096985044 @default.
• W2088579973 cites W2100979164 @default.
• W2088579973 cites W2107394975 @default.
• W2088579973 cites W2115079680 @default.
• W2088579973 cites W2119677723 @default.
• W2088579973 cites W2123478725 @default.
• W2088579973 cites W2128295200 @default.
• W2088579973 cites W2138541587 @default.
• W2088579973 cites W2139221901 @default.
• W2088579973 cites W2167133646 @default.
• W2088579973 cites W2171153690 @default.
• W2088579973 cites W2341009340 @default.
• W2088579973 doi "https://doi.org/10.1002/dvdy.23795" @default.
• W2088579973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4747427" @default.
• W2088579973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22513894" @default.
• W2088579973 hasPublicationYear "2012" @default.
• W2088579973 type Work @default.
• W2088579973 sameAs 2088579973 @default.
• W2088579973 citedByCount "20" @default.
• W2088579973 countsByYear W20885799732013 @default.
• W2088579973 countsByYear W20885799732014 @default.
• W2088579973 countsByYear W20885799732015 @default.
• W2088579973 countsByYear W20885799732018 @default.
• W2088579973 countsByYear W20885799732019 @default.
• W2088579973 countsByYear W20885799732020 @default.
• W2088579973 countsByYear W20885799732021 @default.
• W2088579973 countsByYear W20885799732023 @default.
• W2088579973 crossrefType "journal-article" @default.
• W2088579973 hasAuthorship W2088579973A5025487987 @default.
• W2088579973 hasAuthorship W2088579973A5054935753 @default.
• W2088579973 hasAuthorship W2088579973A5061893588 @default.
• W2088579973 hasAuthorship W2088579973A5075297399 @default.
• W2088579973 hasBestOaLocation W20885799732 @default.
• W2088579973 hasConcept C104317684 @default.
• W2088579973 hasConcept C126322002 @default.
• W2088579973 hasConcept C134018914 @default.
• W2088579973 hasConcept C161879069 @default.
• W2088579973 hasConcept C167734588 @default.
• W2088579973 hasConcept C196843134 @default.
• W2088579973 hasConcept C2777025900 @default.
• W2088579973 hasConcept C2777605378 @default.
• W2088579973 hasConcept C2778539099 @default.
• W2088579973 hasConcept C2780394083 @default.
• W2088579973 hasConcept C502942594 @default.
• W2088579973 hasConcept C54355233 @default.
• W2088579973 hasConcept C62478195 @default.
• W2088579973 hasConcept C6929976 @default.
• W2088579973 hasConcept C71924100 @default.
• W2088579973 hasConcept C86803240 @default.
• W2088579973 hasConcept C88498014 @default.
• W2088579973 hasConcept C95444343 @default.
• W2088579973 hasConceptScore W2088579973C104317684 @default.
• W2088579973 hasConceptScore W2088579973C126322002 @default.
• W2088579973 hasConceptScore W2088579973C134018914 @default.
• W2088579973 hasConceptScore W2088579973C161879069 @default.
• W2088579973 hasConceptScore W2088579973C167734588 @default.
• W2088579973 hasConceptScore W2088579973C196843134 @default.
• W2088579973 hasConceptScore W2088579973C2777025900 @default.
• W2088579973 hasConceptScore W2088579973C2777605378 @default.
• W2088579973 hasConceptScore W2088579973C2778539099 @default.
• W2088579973 hasConceptScore W2088579973C2780394083 @default.
• W2088579973 hasConceptScore W2088579973C502942594 @default.
• W2088579973 hasConceptScore W2088579973C54355233 @default.
• W2088579973 hasConceptScore W2088579973C62478195 @default.
• W2088579973 hasConceptScore W2088579973C6929976 @default.
• W2088579973 hasConceptScore W2088579973C71924100 @default.
• W2088579973 hasConceptScore W2088579973C86803240 @default.
• W2088579973 hasConceptScore W2088579973C88498014 @default.
• W2088579973 hasConceptScore W2088579973C95444343 @default.
• W2088579973 hasIssue "6" @default.

• next