Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088580309> ?p ?o ?g. }
- W2088580309 endingPage "726" @default.
- W2088580309 startingPage "714" @default.
- W2088580309 abstract "Clonal evolution is a key feature of cancer progression and relapse. We studied intratumoral heterogeneity in 149 chronic lymphocytic leukemia (CLL) cases by integrating whole-exome sequence and copy number to measure the fraction of cancer cells harboring each somatic mutation. We identified driver mutations as predominantly clonal (e.g., MYD88, trisomy 12, and del(13q)) or subclonal (e.g., SF3B1 and TP53), corresponding to earlier and later events in CLL evolution. We sampled leukemia cells from 18 patients at two time points. Ten of twelve CLL cases treated with chemotherapy (but only one of six without treatment) underwent clonal evolution, predominantly involving subclones with driver mutations (e.g., SF3B1 and TP53) that expanded over time. Furthermore, presence of a subclonal driver mutation was an independent risk factor for rapid disease progression. Our study thus uncovers patterns of clonal evolution in CLL, providing insights into its stepwise transformation, and links the presence of subclones with adverse clinical outcomes." @default.
- W2088580309 created "2016-06-24" @default.
- W2088580309 creator A5001392592 @default.
- W2088580309 creator A5002930435 @default.
- W2088580309 creator A5003120045 @default.
- W2088580309 creator A5003947352 @default.
- W2088580309 creator A5006575032 @default.
- W2088580309 creator A5009506175 @default.
- W2088580309 creator A5012348736 @default.
- W2088580309 creator A5016570475 @default.
- W2088580309 creator A5020748592 @default.
- W2088580309 creator A5022172869 @default.
- W2088580309 creator A5023492006 @default.
- W2088580309 creator A5024772763 @default.
- W2088580309 creator A5041619925 @default.
- W2088580309 creator A5045653197 @default.
- W2088580309 creator A5047701430 @default.
- W2088580309 creator A5048859270 @default.
- W2088580309 creator A5054785454 @default.
- W2088580309 creator A5056373767 @default.
- W2088580309 creator A5056650437 @default.
- W2088580309 creator A5070808897 @default.
- W2088580309 creator A5072335233 @default.
- W2088580309 creator A5076769254 @default.
- W2088580309 creator A5080618346 @default.
- W2088580309 creator A5080842226 @default.
- W2088580309 creator A5085713254 @default.
- W2088580309 creator A5086217179 @default.
- W2088580309 date "2013-02-01" @default.
- W2088580309 modified "2023-10-12" @default.
- W2088580309 title "Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia" @default.
- W2088580309 cites W1964938516 @default.
- W2088580309 cites W1973568247 @default.
- W2088580309 cites W1977859620 @default.
- W2088580309 cites W1979918288 @default.
- W2088580309 cites W1979946545 @default.
- W2088580309 cites W1989891384 @default.
- W2088580309 cites W1993355130 @default.
- W2088580309 cites W1997795685 @default.
- W2088580309 cites W2012753533 @default.
- W2088580309 cites W2017760549 @default.
- W2088580309 cites W2017906827 @default.
- W2088580309 cites W2021341670 @default.
- W2088580309 cites W2023560061 @default.
- W2088580309 cites W2027246028 @default.
- W2088580309 cites W2029154060 @default.
- W2088580309 cites W2031121711 @default.
- W2088580309 cites W2032518018 @default.
- W2088580309 cites W2034506209 @default.
- W2088580309 cites W2035918677 @default.
- W2088580309 cites W2038477042 @default.
- W2088580309 cites W2058174458 @default.
- W2088580309 cites W2059865316 @default.
- W2088580309 cites W2060310306 @default.
- W2088580309 cites W2060383229 @default.
- W2088580309 cites W2063382533 @default.
- W2088580309 cites W2064519910 @default.
- W2088580309 cites W2071265398 @default.
- W2088580309 cites W2073889874 @default.
- W2088580309 cites W2078943658 @default.
- W2088580309 cites W2080660780 @default.
- W2088580309 cites W2086108703 @default.
- W2088580309 cites W2090008987 @default.
- W2088580309 cites W2091168608 @default.
- W2088580309 cites W2091797506 @default.
- W2088580309 cites W2092741708 @default.
- W2088580309 cites W2093144236 @default.
- W2088580309 cites W2097141283 @default.
- W2088580309 cites W2097349248 @default.
- W2088580309 cites W2101035019 @default.
- W2088580309 cites W2102140136 @default.
- W2088580309 cites W2107665951 @default.
- W2088580309 cites W2109991075 @default.
- W2088580309 cites W2115875921 @default.
- W2088580309 cites W2116248495 @default.
- W2088580309 cites W2116382435 @default.
- W2088580309 cites W2116431837 @default.
- W2088580309 cites W2120010359 @default.
- W2088580309 cites W2121531763 @default.
- W2088580309 cites W2122598723 @default.
- W2088580309 cites W2125792957 @default.
- W2088580309 cites W2127041368 @default.
- W2088580309 cites W2128343424 @default.
- W2088580309 cites W2133201432 @default.
- W2088580309 cites W2138601221 @default.
- W2088580309 cites W2142099365 @default.
- W2088580309 cites W2145191876 @default.
- W2088580309 cites W2145842706 @default.
- W2088580309 cites W2150575159 @default.
- W2088580309 cites W2153056550 @default.
- W2088580309 cites W2154911534 @default.
- W2088580309 cites W2156141983 @default.
- W2088580309 cites W2157783208 @default.
- W2088580309 cites W2157852151 @default.
- W2088580309 cites W2158102062 @default.
- W2088580309 cites W2159715390 @default.
- W2088580309 cites W2168133698 @default.
- W2088580309 cites W2170490448 @default.