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• W2088584513 startingPage "97" @default.
• W2088584513 abstract "Herein, we report the first characterization of Shab slow inactivation. Open Shab channels inactivate within seconds, with two voltage-independent time constants. Additionally, Shab presents significant closed-state inactivation. We found that with short depolarizing pulses, shorter than the slowest inactivation time constant, the resulting inactivation curve has a marked U-shape, but as pulse duration increases, approaching steady-state conditions, the U-shape vanishes, and the resulting inactivation curves converge to the classical Boltzmann h∞ curve. Regarding the mechanism of inactivation, we found that external K+ and TEA facilitate both open- and closed-state inactivation, while the cavity blocker quinidine hinders inactivation. These results together with our previous observations regarding the K+-dependent stability of the K+ conductance, suggest the novel hypothesis that inactivation of Shab channels, and possibly that of other Kv channels whose inactivation is facilitated by K+, does not involve a significant narrowing of the extracellular entry of the pore. Instead, we hypothesize that there is only a rearrangement of a more internal segment of the pore that affects the central cavity and halts K+ conduction." @default.
• W2088584513 created "2016-06-24" @default.
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• W2088584513 date "2013-03-17" @default.
• W2088584513 modified "2023-10-15" @default.
• W2088584513 title "Shab K⁺channel slow inactivation" @default.
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• W2088584513 doi "https://doi.org/10.4161/chan.23569" @default.
• W2088584513 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3667890" @default.
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