Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088592005> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2088592005 endingPage "188" @default.
- W2088592005 startingPage "181" @default.
- W2088592005 abstract "The effect of heparin as an anticoagulant was examined and the extent of fibrinolytic activity during cardiopulmonary bypass (CPB) was measured. Twenty patients undergoing valve replacement or aortocoronary bypass surgery were studied. Fibrinopeptide A (FPA) levels gradually became elevated as CPB proceeded, and antithrombin III (AT III) decreased during CPB. This indicates that despite the use of heparin, the coagulation system was activated, leading to fibrin formation in the microcirculation. On the other hand, fibrinopeptide B (FPB β 15–42) also increased to four times the preoperative value at two hours on CPB. Intrinsic fibrinolytic activity, as determined by the activity of kaolin-activated euglobulin, was transiently increased only at the beginning of CPB. The C1 inactivator-resistant fibrinolytic activity and tissue plasminogen activator antigen (t-PA;Ag) increased sharply during CPB and reached maximum levels one hour after the start of CPB, indicating that enhanced fibrinolytic activity during CPB is predominantly of extrinsic origin as the result of t-PA release from the vascular walls. It is concluded from the above findings that thrombin activity continues during CPB. Enhanced fibrinolytic activity during CPB appears to be important because t-PA activates plasminogen predominantly where fibrin is formed, leading to dissolution of the microthrombi formed during CPB." @default.
- W2088592005 created "2016-06-24" @default.
- W2088592005 creator A5002633223 @default.
- W2088592005 creator A5004769073 @default.
- W2088592005 creator A5013990494 @default.
- W2088592005 creator A5073353601 @default.
- W2088592005 creator A5085310389 @default.
- W2088592005 creator A5085468494 @default.
- W2088592005 date "1989-04-01" @default.
- W2088592005 modified "2023-09-23" @default.
- W2088592005 title "Alterations in coagulation and fibrinolysis associated with cardiopulmonary bypass during open heart surgery" @default.
- W2088592005 cites W129597058 @default.
- W2088592005 cites W2015159702 @default.
- W2088592005 cites W2021598312 @default.
- W2088592005 cites W2027057902 @default.
- W2088592005 cites W2043266913 @default.
- W2088592005 cites W2055500222 @default.
- W2088592005 cites W2068114006 @default.
- W2088592005 cites W2136629589 @default.
- W2088592005 cites W2144174952 @default.
- W2088592005 doi "https://doi.org/10.1016/s0888-6296(89)92642-2" @default.
- W2088592005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2535275" @default.
- W2088592005 hasPublicationYear "1989" @default.
- W2088592005 type Work @default.
- W2088592005 sameAs 2088592005 @default.
- W2088592005 citedByCount "157" @default.
- W2088592005 countsByYear W20885920052012 @default.
- W2088592005 countsByYear W20885920052013 @default.
- W2088592005 countsByYear W20885920052014 @default.
- W2088592005 countsByYear W20885920052015 @default.
- W2088592005 countsByYear W20885920052016 @default.
- W2088592005 countsByYear W20885920052017 @default.
- W2088592005 countsByYear W20885920052018 @default.
- W2088592005 countsByYear W20885920052020 @default.
- W2088592005 countsByYear W20885920052021 @default.
- W2088592005 countsByYear W20885920052022 @default.
- W2088592005 crossrefType "journal-article" @default.
- W2088592005 hasAuthorship W2088592005A5002633223 @default.
- W2088592005 hasAuthorship W2088592005A5004769073 @default.
- W2088592005 hasAuthorship W2088592005A5013990494 @default.
- W2088592005 hasAuthorship W2088592005A5073353601 @default.
- W2088592005 hasAuthorship W2088592005A5085310389 @default.
- W2088592005 hasAuthorship W2088592005A5085468494 @default.
- W2088592005 hasConcept C126322002 @default.
- W2088592005 hasConcept C164705383 @default.
- W2088592005 hasConcept C203014093 @default.
- W2088592005 hasConcept C2776572282 @default.
- W2088592005 hasConcept C2776825266 @default.
- W2088592005 hasConcept C2777557582 @default.
- W2088592005 hasConcept C2778382381 @default.
- W2088592005 hasConcept C2778881276 @default.
- W2088592005 hasConcept C2779026020 @default.
- W2088592005 hasConcept C2779679481 @default.
- W2088592005 hasConcept C42219234 @default.
- W2088592005 hasConcept C54173615 @default.
- W2088592005 hasConcept C71924100 @default.
- W2088592005 hasConceptScore W2088592005C126322002 @default.
- W2088592005 hasConceptScore W2088592005C164705383 @default.
- W2088592005 hasConceptScore W2088592005C203014093 @default.
- W2088592005 hasConceptScore W2088592005C2776572282 @default.
- W2088592005 hasConceptScore W2088592005C2776825266 @default.
- W2088592005 hasConceptScore W2088592005C2777557582 @default.
- W2088592005 hasConceptScore W2088592005C2778382381 @default.
- W2088592005 hasConceptScore W2088592005C2778881276 @default.
- W2088592005 hasConceptScore W2088592005C2779026020 @default.
- W2088592005 hasConceptScore W2088592005C2779679481 @default.
- W2088592005 hasConceptScore W2088592005C42219234 @default.
- W2088592005 hasConceptScore W2088592005C54173615 @default.
- W2088592005 hasConceptScore W2088592005C71924100 @default.
- W2088592005 hasIssue "2" @default.
- W2088592005 hasLocation W20885920051 @default.
- W2088592005 hasLocation W20885920052 @default.
- W2088592005 hasOpenAccess W2088592005 @default.
- W2088592005 hasPrimaryLocation W20885920051 @default.
- W2088592005 hasRelatedWork W1990682178 @default.
- W2088592005 hasRelatedWork W2026844481 @default.
- W2088592005 hasRelatedWork W2088203721 @default.
- W2088592005 hasRelatedWork W2088592005 @default.
- W2088592005 hasRelatedWork W2144174952 @default.
- W2088592005 hasRelatedWork W2266515308 @default.
- W2088592005 hasRelatedWork W2417530232 @default.
- W2088592005 hasRelatedWork W2418426145 @default.
- W2088592005 hasRelatedWork W32463445 @default.
- W2088592005 hasRelatedWork W4252699603 @default.
- W2088592005 hasVolume "3" @default.
- W2088592005 isParatext "false" @default.
- W2088592005 isRetracted "false" @default.
- W2088592005 magId "2088592005" @default.
- W2088592005 workType "article" @default.