FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088593885> ?p ?o ?g. }

• W2088593885 endingPage "1254" @default.
• W2088593885 startingPage "1249" @default.
• W2088593885 abstract "The interaction of the T cell receptor with the antigen/major histocompatibility class II complex is insufficient to induce optimal T cell activation. Co-stimulatory signals, including those provided by CD28/CTLA-4 on T cells and B7 molecules (B7-1, -2, and -3) on antigen-presenting cells, are also required. CD28-B7 interactions can be blocked by a soluble human CTLA-4 chimeric protein (CTLA4Ig). We tested the effect of administration of CTLA4Ig on experimental anti-glomerular basement membrane (GBM) autoimmune glomerulonephritis in Wistar-Kyoto rats induced by immunization with bovine GBM. The disease is characterized by development of antibody to the alpha 3 chain of type IV collagen (Goodpasture's antigen), deposition of rat IgG in GBM, infiltration of the kidney by T cells and macrophages, severe crescent formation and renal failure leading to death in 5-6 weeks. Animals injected with human CTLA4Ig from day 0 to day 14 or to day 35 had reduced disease severity. Beneficial effects were observed even when injections were begun after the onset of glomerulonephritis on day 14. However, the rats developed antibody to the human CTLA4Ig, associated with reduction in levels of circulating CTLA4Ig. The results provide evidence for CD28/CTLA-4 signaling in rat autoimmune glomerulonephritis, and suggest that more effective inhibition of B7-dependent T cell activation, such as might be achieved with homologous CTLA4Ig, could be useful in the treatment of autoimmune diseases." @default.
• W2088593885 created "2016-06-24" @default.
• W2088593885 creator A5007648823 @default.
• W2088593885 creator A5041139639 @default.
• W2088593885 creator A5045232280 @default.
• W2088593885 creator A5058977289 @default.
• W2088593885 creator A5062610230 @default.
• W2088593885 creator A5073926001 @default.
• W2088593885 date "1994-06-01" @default.
• W2088593885 modified "2023-09-23" @default.
• W2088593885 title "Effect of CTLA-4 chimeric protein on rat autoimmune anti-glomerular basement membrane glomerulonephritis" @default.
• W2088593885 cites W2037374883 @default.
• W2088593885 cites W2041402027 @default.
• W2088593885 cites W2045654426 @default.
• W2088593885 cites W2062994475 @default.
• W2088593885 cites W2077389439 @default.
• W2088593885 cites W2087013294 @default.
• W2088593885 cites W2090481553 @default.
• W2088593885 cites W2092233067 @default.
• W2088593885 cites W2100117872 @default.
• W2088593885 cites W2101988889 @default.
• W2088593885 cites W2106531897 @default.
• W2088593885 cites W2125547273 @default.
• W2088593885 doi "https://doi.org/10.1002/eji.1830240602" @default.
• W2088593885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8206086" @default.
• W2088593885 hasPublicationYear "1994" @default.
• W2088593885 type Work @default.
• W2088593885 sameAs 2088593885 @default.
• W2088593885 citedByCount "66" @default.
• W2088593885 countsByYear W20885938852013 @default.
• W2088593885 countsByYear W20885938852014 @default.
• W2088593885 countsByYear W20885938852015 @default.
• W2088593885 countsByYear W20885938852019 @default.
• W2088593885 countsByYear W20885938852022 @default.
• W2088593885 crossrefType "journal-article" @default.
• W2088593885 hasAuthorship W2088593885A5007648823 @default.
• W2088593885 hasAuthorship W2088593885A5041139639 @default.
• W2088593885 hasAuthorship W2088593885A5045232280 @default.
• W2088593885 hasAuthorship W2088593885A5058977289 @default.
• W2088593885 hasAuthorship W2088593885A5062610230 @default.
• W2088593885 hasAuthorship W2088593885A5073926001 @default.
• W2088593885 hasConcept C134018914 @default.
• W2088593885 hasConcept C147483822 @default.
• W2088593885 hasConcept C148125776 @default.
• W2088593885 hasConcept C159654299 @default.
• W2088593885 hasConcept C167672396 @default.
• W2088593885 hasConcept C203014093 @default.
• W2088593885 hasConcept C207936829 @default.
• W2088593885 hasConcept C21705690 @default.
• W2088593885 hasConcept C2776090121 @default.
• W2088593885 hasConcept C2776115139 @default.
• W2088593885 hasConcept C2776193487 @default.
• W2088593885 hasConcept C2777058396 @default.
• W2088593885 hasConcept C2779075594 @default.
• W2088593885 hasConcept C2780091579 @default.
• W2088593885 hasConcept C2780130043 @default.
• W2088593885 hasConcept C2780368995 @default.
• W2088593885 hasConcept C86803240 @default.
• W2088593885 hasConcept C8891405 @default.
• W2088593885 hasConcept C95444343 @default.
• W2088593885 hasConceptScore W2088593885C134018914 @default.
• W2088593885 hasConceptScore W2088593885C147483822 @default.
• W2088593885 hasConceptScore W2088593885C148125776 @default.
• W2088593885 hasConceptScore W2088593885C159654299 @default.
• W2088593885 hasConceptScore W2088593885C167672396 @default.
• W2088593885 hasConceptScore W2088593885C203014093 @default.
• W2088593885 hasConceptScore W2088593885C207936829 @default.
• W2088593885 hasConceptScore W2088593885C21705690 @default.
• W2088593885 hasConceptScore W2088593885C2776090121 @default.
• W2088593885 hasConceptScore W2088593885C2776115139 @default.
• W2088593885 hasConceptScore W2088593885C2776193487 @default.
• W2088593885 hasConceptScore W2088593885C2777058396 @default.
• W2088593885 hasConceptScore W2088593885C2779075594 @default.
• W2088593885 hasConceptScore W2088593885C2780091579 @default.
• W2088593885 hasConceptScore W2088593885C2780130043 @default.
• W2088593885 hasConceptScore W2088593885C2780368995 @default.
• W2088593885 hasConceptScore W2088593885C86803240 @default.
• W2088593885 hasConceptScore W2088593885C8891405 @default.
• W2088593885 hasConceptScore W2088593885C95444343 @default.
• W2088593885 hasIssue "6" @default.
• W2088593885 hasLocation W20885938851 @default.
• W2088593885 hasLocation W20885938852 @default.
• W2088593885 hasOpenAccess W2088593885 @default.
• W2088593885 hasPrimaryLocation W20885938851 @default.
• W2088593885 hasRelatedWork W1964608434 @default.
• W2088593885 hasRelatedWork W1967109495 @default.
• W2088593885 hasRelatedWork W1978699764 @default.
• W2088593885 hasRelatedWork W2007843286 @default.
• W2088593885 hasRelatedWork W2024909126 @default.
• W2088593885 hasRelatedWork W2041974941 @default.
• W2088593885 hasRelatedWork W2052688737 @default.
• W2088593885 hasRelatedWork W2088593885 @default.
• W2088593885 hasRelatedWork W2135368684 @default.
• W2088593885 hasRelatedWork W2608950432 @default.
• W2088593885 hasVolume "24" @default.
• W2088593885 isParatext "false" @default.
• W2088593885 isRetracted "false" @default.
• W2088593885 magId "2088593885" @default.

• next