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• W2088594259 abstract "Background and Aims: Yi Guan Jian (YGJ) is a traditional herbal medicine that frequently used for especially digestive disorders in China. In this study, YGJ was investigated for the hepatoprotective and antihepatofibrotic effects and its related mechanisms in DMN-induced animal model. The present investigation was designed to assess the involvement of the fibrosis pathway in DMN-induced liver fibrosis in rats and molecular mechanisms underlying prevention of liver fibrosis . Methods: Eighteen Sprague-Dawley rats were divided into three groups of six rats each, liver fibrosis was induced by DMN injection (10mg kg, ip, given three consecutive days each week) following 4 weeks. YGJ was oral administered (1.8 g kg, op, daily via gastrogavage for two weeks). Liver sample were subjected to histological and western bolt studies. For evaluation of hepatic fibrosis-related factors, collagen α1-I, tissue inhibitor of metalloproteinase-1 (TIMP-1), and α-smooth muscle actin (α-SMA) mRNA and protein levels were analyzed. Associated mechanisms were confirmed in vitro using HSC-T6 cell lines. Results: YGJ significantly attenuated the DMN-induced excessive level of GOT and GPT (p < 0.01) in serum, and hydroxyproline content in liver tissue (p <0.001). Histophathological result revealed that YGJ markedly reduced collagen acumination and hepatic satellite cells activation. In gene expression analysis, YGJ down regulated fibrosis-related genes including TIMP-1, collagen α1-I and α-SMA in liver tissue. In protein level, YGJ reduced the α-SMA in liver tissue (p <0.001). YGJ induced HSCs apoptosis concomitant with the down-regulation of Bcl-2 expression and slight elevation of Bax level. Moreover, the reactive oxygen species (ROS) were generated in the early stages of YGJ-induced HSCs apoptosis to facilitate calcium and cytochrome c release from the mitochondria to cytosol. Subsequently, caspase-9 and caspase-3 were activated. YGJ decoction induces HSCs apoptosis through ROS accumulation and the intrinsic apoptosis pathway. Conclusions: These result showed that YGJ has hepatoprotective and antihepatofibrotic effects against DMN-induced liver fibrosis. Its possible mechanisms are associated with HSCs apoptosis through ROS accumulation and down-regulation of the fibrogenic gene, especially TIMP-1, collagen α1-I and α-SMA." @default.
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• W2088594259 date "2011-03-01" @default.
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• W2088594259 title "593 HEPATOPROTECnVE AND ANTIHEPATOFIBROTIC EFFECTS OF YI GUAN JIAN IN RATS WITH DIMETHYLNITROSAMINE-INDUCED LIVER FIBROSIS" @default.
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• W2088594259 doi "https://doi.org/10.1016/s0168-8278(11)60595-3" @default.
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