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• W2088594666 abstract "To increase awareness of giant cell myocarditis (GCM), its pathogenesis, and treatment.Review of relevant publications from the English-language literature.GCM is a rare, frequently fatal inflammatory disorder of cardiac muscle of unknown origin, characterized by widespread degeneration and necrosis of myocardial fibers.Congestive heart failure and ventricular tachycardia are common clinical manifestations. GCM occurs primarily in previously healthy adults, although it is frequently associated with various systemic diseases, primarily of autoimmune causes. The inflammatory infiltrate is characterized by the presence of multinucleated giant cells and is distinct from cardiac sarcoidosis. Animal models of GCM are similar to models of other autoimmune disorders such as rheumatoid arthritis. The prognosis, which is poor despite partial responsiveness to immunosuppressive medications, is improved with cardiac transplantation.The clinical and immunopathogenetic similarities with classical rheumatologic diseases, the differential diagnosis with sarcoidosis and other inflammatory conditions, and the use of standard immunosuppressive medications make GCM a disease process that should be added to the rheumatologist's expertise." @default.
• W2088594666 created "2016-06-24" @default.
• W2088594666 creator A5015868265 @default.
• W2088594666 creator A5065231213 @default.
• W2088594666 creator A5084152442 @default.
• W2088594666 date "2000-08-01" @default.
• W2088594666 modified "2023-10-18" @default.
• W2088594666 title "Giant cell myocarditis: Most fatal of autoimmune diseases" @default.
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