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- W2088597321 abstract "IntroductionAutologous chondrocyte implantation (ACI) requires two-step surgical procedure, first to isolate the chondrocytes, and then to implant the in vitro cultured cells. Because of cost, time, and the special culture facilities needed, ACI has limited clinical application. Furthermore, the chondrocytes used for implantation are harvested from normal cartilage of the same joint, limiting the number of available cells.Recently, a direct implantation of minced cartilage in articular cartilage defects was attempted to omit the in vitro cell culture step [1Lu Y. et al.J Orthop Res. 2006; Google Scholar]. Although it was possible to improve implantation from a two-step to one-step procedure, the problem with ACI of having a limited number of cells for implantation remains unresolved. Thus, recent attempts have been made to use chondroprogenitor cells like synovium-derived cells, which were considered to be useful for cartilage implants [2Sakaguchi Y. et al.Arthritis Rheum. 2005; PubMed Google Scholar, 3Shintani N. et al.Arthritis Rheum. 2007; PubMed Google Scholar].We hypothesized that combined implantation of minced cartilage and enzymatically isolated primary synovial cells might be useful as a novel, one-step repair approach to solve the problems associated with ACI. Therefore, in the present study, we investigated the effects of co-implantation of minced cartilage with uncultured primary synovial cells on the chondrogenic differentiation of the synovial cells." @default.
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- W2088597321 date "2011-10-01" @default.
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- W2088597321 title "Paper # 158: Co-implantation with Minced Articular Cartilage Enhances Chondrogenic Differentiation of Synovial Cells" @default.
- W2088597321 doi "https://doi.org/10.1016/j.arthro.2011.08.158" @default.
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