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• W2088598869 abstract "Histamine at molar concentrations ranging from 10(-5) to 10(-7) exerted an inhibitory effect upon IL-2 synthesis by peripheral blood mononuclear cells in normal man; two pathways of inhibition are described. The first pathway was found to alter the T4 lymphocytes which, in the system used in this study, synthesized nearly 90% of the total IL-2 production and had no suppressive activity. This suggests that histamine can act at the level of IL-2-producing cells. The second pathway of inhibition was related to induction of suppressor cells. Peripheral blood lymphocytes pre-incubated for 1 h with histamine 10(-5)-10(-7) M inhibited the IL-2 synthesis of normal autologous lymphocytes in a co-culture system. This activity was radio-resistant (1200 r) and mediated by T8 lymphocytes. These two pathways of inhibition were mediated by the specific interaction of histamine with H1- and H2-receptor-bearing mononuclear cells." @default.
• W2088598869 created "2016-06-24" @default.
• W2088598869 creator A5062222202 @default.
• W2088598869 creator A5091178354 @default.
• W2088598869 date "1988-09-01" @default.
• W2088598869 modified "2023-09-27" @default.
• W2088598869 title "Histamine-induced regulation of IL-2 synthesis in man: Characterization of two pathways of inhibition" @default.
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• W2088598869 doi "https://doi.org/10.1016/0769-2625(88)90094-3" @default.
• W2088598869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2905136" @default.
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