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- W2088630512 abstract "Glutamine and vitamin E may prevent hepatic ischemia–reperfusion (I/R) injuries. Our aim was to investigate the effects of glutamine, either alone or combined with vitamin E, against I/R in the isolated perfused rat liver.Four groups of 8 livers from male Sprague-Dawley rats were isolated and submitted to a 45-min no-flow ischemia and reperfusion in the presence of alanine 2 mM, alanine 2 mM plus vitamin E 150 μM, Alanyl-Glutamine (AlaGln) 2 mM, or AlaGln 2 mM plus vitamin E 150 μM. Six non-perfused livers were studied in parallel. Liver function, metabolic parameters, oxidative stress and inflammatory parameters have been studied.AlaGln was rapidly cleared from the perfusate (436 ± 41 nmol min−1 g−1) and lowered transaminase release during reperfusion (ALT: −59%), significantly so in the AlaGln + Vit E group (ALT: −65%, p < 0.05). The association of glutamine with vitamin E led to lower °NO (−83%, p < 0.05) production, better preserved hepatic glutathione content and, as with vitamin E alone, preserved hepatic vitamin A and significantly decreased malondialdehyde (−85%, p < 0.05).Both glutamine, by attenuating inflammatory response, and vitamin E, via its antioxidative properties, showed complementary protective effects against I/R-induced hepatic injury. These data emphasize the potential benefit of combining glutamine and vitamin E supplementation in hepatic I/R injury." @default.
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- W2088630512 date "1998-05-01" @default.
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- W2088630512 title "Effects of α-Tocopherol on Reperfusion Injury in the Canine Small Bowel Autotransplantation Model" @default.
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- W2088630512 doi "https://doi.org/10.1016/s0041-1345(98)00064-5" @default.
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