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- W2088632613 abstract "Preparation of the key intermediate carboxydifluoromethanesulfonamide provides direct synthetic access to a wide range of novel difluoromethanesulfonamides, including the acetazolamide analogue (2-ethanoylamino-1,3,4-thiadiazol-5-yl)-difluoromethanesulfonamide. Their water solubility and stability, ether partition coefficient, pKa and submicromolar dissociation constants for human carbonic anhydrase isozyme II (HCA II) make them promising candidates for topical glaucoma therapy." @default.
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- W2088632613 date "2005-01-01" @default.
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- W2088632613 title "A new synthesis of difluoromethanesulfonamides–a novel pharmacophore for carbonic anhydrase inhibition" @default.
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- W2088632613 doi "https://doi.org/10.1039/b416642f" @default.
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