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- W2088642014 abstract "The objective of this paper is to review the epidemiology, manifestations, therapy, and prevention of viral hepatitis in older people and to discuss issues of prevention and management. In developed countries a significant portion of the adult population is not immune to Hepatitis A virus (HAV). Morbidity and mortality from HAV infection increases with age. A safe and effective hepatitis A vaccine is available and health authorities should consider immunization early in life and for healthy adults as well as for potential high risk groups such as nursing home residents. Acute hepatitis due to Hepatitis B virus (HBV)is rare in older people and is usually a mild disease. Most older patients with chronic HBV infection who suffer from advanced liver disease have no evidence of ongoing viral replication. Therefore, they are not candidates for interferon therapy. Those with evidence of ongoing viral replication and compensated liver disease should be offered interferon or be included in clinical trials with new antiviral drugs such as lamivudine. Since the response rate to hepatitis B vaccination decreases with age, developing vaccines with greater immunogenicity is crucial. Hepatitis C virus (HCV) is the most frequent cause of acute viral hepatitis in older people. Acute hepatitis C is usually a mild disease in this age group. Because many older patients with chronic HCV infection have compensated liver disease, they could benefit from antiviral therapy. In light of the low response rate to interferon in older patients with chronic hepatitis C and the side effects of the drug, interferon therapy should be reserved for those with the best chance of response. “Combination” antiviral therapy should be on trial for older patients with chronic HCV infection who do not respond to interferon. The recently discovered RNA virus, Hepatitis G (HGV), has been associated with liver disease in older people. It's role in the pathogenesis of liver injury remains to be elucidated." @default.
- W2088642014 created "2016-06-24" @default.
- W2088642014 creator A5061918599 @default.
- W2088642014 creator A5078317501 @default.
- W2088642014 date "1997-06-01" @default.
- W2088642014 modified "2023-10-18" @default.
- W2088642014 title "Viral Hepatitis in Older Adults" @default.
- W2088642014 cites W1553514749 @default.
- W2088642014 cites W1605870473 @default.
- W2088642014 cites W161322650 @default.
- W2088642014 cites W1963636589 @default.
- W2088642014 cites W1964005569 @default.
- W2088642014 cites W1964088266 @default.
- W2088642014 cites W1966590194 @default.
- W2088642014 cites W1968209994 @default.
- W2088642014 cites W1968566170 @default.
- W2088642014 cites W1969992332 @default.
- W2088642014 cites W1972742092 @default.
- W2088642014 cites W1973080682 @default.
- W2088642014 cites W1973567235 @default.
- W2088642014 cites W1974932469 @default.
- W2088642014 cites W1977972110 @default.
- W2088642014 cites W1982480711 @default.
- W2088642014 cites W1985882441 @default.
- W2088642014 cites W1985998515 @default.
- W2088642014 cites W1987171478 @default.
- W2088642014 cites W1988905354 @default.
- W2088642014 cites W1989385464 @default.
- W2088642014 cites W1992099852 @default.
- W2088642014 cites W1994853928 @default.
- W2088642014 cites W1995190108 @default.
- W2088642014 cites W1997248565 @default.
- W2088642014 cites W1997368021 @default.
- W2088642014 cites W2003532680 @default.
- W2088642014 cites W2011235425 @default.
- W2088642014 cites W2014126136 @default.
- W2088642014 cites W2016677438 @default.
- W2088642014 cites W2022234205 @default.
- W2088642014 cites W2022263369 @default.
- W2088642014 cites W2023951339 @default.
- W2088642014 cites W2023962288 @default.
- W2088642014 cites W2028659418 @default.
- W2088642014 cites W2032208520 @default.
- W2088642014 cites W2043985689 @default.
- W2088642014 cites W2044333260 @default.
- W2088642014 cites W2051973309 @default.
- W2088642014 cites W2055270948 @default.
- W2088642014 cites W2058350561 @default.
- W2088642014 cites W2059372215 @default.
- W2088642014 cites W2063089198 @default.
- W2088642014 cites W2066003773 @default.
- W2088642014 cites W2066146860 @default.
- W2088642014 cites W2069633422 @default.
- W2088642014 cites W2072775877 @default.
- W2088642014 cites W2077738168 @default.
- W2088642014 cites W2079002457 @default.
- W2088642014 cites W2079377965 @default.
- W2088642014 cites W2082558666 @default.
- W2088642014 cites W2082804044 @default.
- W2088642014 cites W2082930860 @default.
- W2088642014 cites W2083234230 @default.
- W2088642014 cites W2083266836 @default.
- W2088642014 cites W2084984586 @default.
- W2088642014 cites W2086542415 @default.
- W2088642014 cites W2102803729 @default.
- W2088642014 cites W2104475038 @default.
- W2088642014 cites W2112152545 @default.
- W2088642014 cites W2117991256 @default.
- W2088642014 cites W2118047427 @default.
- W2088642014 cites W2123384191 @default.
- W2088642014 cites W2127326020 @default.
- W2088642014 cites W2133953629 @default.
- W2088642014 cites W2138053123 @default.
- W2088642014 cites W2140384722 @default.
- W2088642014 cites W2150102564 @default.
- W2088642014 cites W2154030572 @default.
- W2088642014 cites W2158736090 @default.
- W2088642014 cites W2163692778 @default.
- W2088642014 cites W2163973830 @default.
- W2088642014 cites W2166985999 @default.
- W2088642014 cites W2309477817 @default.
- W2088642014 cites W2312239394 @default.
- W2088642014 cites W2313300349 @default.
- W2088642014 cites W2323719395 @default.
- W2088642014 cites W2328171401 @default.
- W2088642014 cites W2333237823 @default.
- W2088642014 cites W2336905550 @default.
- W2088642014 cites W2394576742 @default.
- W2088642014 cites W2399148813 @default.
- W2088642014 cites W2401475823 @default.
- W2088642014 cites W2402295136 @default.
- W2088642014 cites W2437864828 @default.
- W2088642014 cites W4206608510 @default.
- W2088642014 cites W4233520648 @default.
- W2088642014 cites W4237060995 @default.
- W2088642014 cites W4240870472 @default.
- W2088642014 cites W4244859913 @default.
- W2088642014 cites W4255232055 @default.