Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088642275> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2088642275 endingPage "57" @default.
- W2088642275 startingPage "54" @default.
- W2088642275 abstract "Canine cardiac native tropomyosin which inhibits Mg2+-ATPase and superprecipitation of desensitized actomyosin in the presence of EGTA contains closely associated protein kinase, as manifested by phosphorylation and stimulation by cyclic-AMP. Native tropomyosin functions as a substrate for the endogenous protein kinase. Native actomyosin and desensitized actomyosin showed no significant cyclic-AMP-dependent or independent phosphorylation either in the presence or absence of added protein kinase. Native tropomyosin was fractionated into components by using hydroxylapatite column chromatography. Of the three components, Peak II (troponin) bound Ca2+; sodium dodecyl sulfate (SDS) gel electrophoresis revealed four subunits; and Peak III (tropomyosin) was a homogeneous protein and did not bind Ca2+. Troponin (Peak II) added to tropomyosin (Peak III) in appropriate concentrations inhibited superprecipitation of desensitized actomyosin in the absence of Ca2+. Peak II (troponin) phosphorylation was catalyzed by bovine cardiac protein kinase. The phosphorylation was markedly stimulated by cyclic-AMP. Peak III (tropomyosin) was not phosphorylated by protein kinase in the presence or absence of cyclic-AMP.The addition of desensitized actomyosin completely inhibited the phosphorylation of native tropomyosin. The data suggest the possible involvement of cyclic-AMP and protein kinase in modulating cardiac contraction and relaxation through and action on troponin." @default.
- W2088642275 created "2016-06-24" @default.
- W2088642275 creator A5055714048 @default.
- W2088642275 creator A5070866637 @default.
- W2088642275 date "1963-09-01" @default.
- W2088642275 modified "2023-10-17" @default.
- W2088642275 title "Is adenosine-3′,5′-phosphate identical with the relaxing substance?" @default.
- W2088642275 cites W1969608439 @default.
- W2088642275 cites W1989356804 @default.
- W2088642275 cites W2015908340 @default.
- W2088642275 cites W2019088084 @default.
- W2088642275 cites W2045937426 @default.
- W2088642275 cites W2056178920 @default.
- W2088642275 cites W2073363851 @default.
- W2088642275 cites W2076015721 @default.
- W2088642275 cites W2088982250 @default.
- W2088642275 cites W2089019629 @default.
- W2088642275 cites W2263889024 @default.
- W2088642275 doi "https://doi.org/10.1016/0006-291x(63)90161-x" @default.
- W2088642275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14069512" @default.
- W2088642275 hasPublicationYear "1963" @default.
- W2088642275 type Work @default.
- W2088642275 sameAs 2088642275 @default.
- W2088642275 citedByCount "4" @default.
- W2088642275 crossrefType "journal-article" @default.
- W2088642275 hasAuthorship W2088642275A5055714048 @default.
- W2088642275 hasAuthorship W2088642275A5070866637 @default.
- W2088642275 hasConcept C115725540 @default.
- W2088642275 hasConcept C116084860 @default.
- W2088642275 hasConcept C11960822 @default.
- W2088642275 hasConcept C12554922 @default.
- W2088642275 hasConcept C125705527 @default.
- W2088642275 hasConcept C126322002 @default.
- W2088642275 hasConcept C178790620 @default.
- W2088642275 hasConcept C185592680 @default.
- W2088642275 hasConcept C205875245 @default.
- W2088642275 hasConcept C2777658833 @default.
- W2088642275 hasConcept C500558357 @default.
- W2088642275 hasConcept C519063684 @default.
- W2088642275 hasConcept C55493867 @default.
- W2088642275 hasConcept C71924100 @default.
- W2088642275 hasConcept C86803240 @default.
- W2088642275 hasConcept C87325107 @default.
- W2088642275 hasConcept C97029542 @default.
- W2088642275 hasConceptScore W2088642275C115725540 @default.
- W2088642275 hasConceptScore W2088642275C116084860 @default.
- W2088642275 hasConceptScore W2088642275C11960822 @default.
- W2088642275 hasConceptScore W2088642275C12554922 @default.
- W2088642275 hasConceptScore W2088642275C125705527 @default.
- W2088642275 hasConceptScore W2088642275C126322002 @default.
- W2088642275 hasConceptScore W2088642275C178790620 @default.
- W2088642275 hasConceptScore W2088642275C185592680 @default.
- W2088642275 hasConceptScore W2088642275C205875245 @default.
- W2088642275 hasConceptScore W2088642275C2777658833 @default.
- W2088642275 hasConceptScore W2088642275C500558357 @default.
- W2088642275 hasConceptScore W2088642275C519063684 @default.
- W2088642275 hasConceptScore W2088642275C55493867 @default.
- W2088642275 hasConceptScore W2088642275C71924100 @default.
- W2088642275 hasConceptScore W2088642275C86803240 @default.
- W2088642275 hasConceptScore W2088642275C87325107 @default.
- W2088642275 hasConceptScore W2088642275C97029542 @default.
- W2088642275 hasIssue "1" @default.
- W2088642275 hasLocation W20886422751 @default.
- W2088642275 hasLocation W20886422752 @default.
- W2088642275 hasOpenAccess W2088642275 @default.
- W2088642275 hasPrimaryLocation W20886422751 @default.
- W2088642275 hasRelatedWork W162570409 @default.
- W2088642275 hasRelatedWork W1971511645 @default.
- W2088642275 hasRelatedWork W2013280477 @default.
- W2088642275 hasRelatedWork W2023555847 @default.
- W2088642275 hasRelatedWork W2041295821 @default.
- W2088642275 hasRelatedWork W2066585573 @default.
- W2088642275 hasRelatedWork W2094587745 @default.
- W2088642275 hasRelatedWork W2099644949 @default.
- W2088642275 hasRelatedWork W2116347482 @default.
- W2088642275 hasRelatedWork W320286279 @default.
- W2088642275 hasVolume "13" @default.
- W2088642275 isParatext "false" @default.
- W2088642275 isRetracted "false" @default.
- W2088642275 magId "2088642275" @default.
- W2088642275 workType "article" @default.