Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088645908> ?p ?o ?g. }
- W2088645908 endingPage "1422" @default.
- W2088645908 startingPage "1412" @default.
- W2088645908 abstract "Antibodies to human immunodeficiency virus (HIV) of the IgA, IgG, and IgM isotypes and high levels of the HIV suppressive β-chemokine RANTES (regulated on activation, normally T cell expressed and secreted) were found in the cervicovaginal secretions (CVSs) of 7.5% of 342 multiply and repeatedly exposed African HIV-seronegative female sex workers. The antibodies are part of a local compartmentalized secretory immune response to HIV, since they are present in vaginal fluids that are free of contaminating semen. Cervicovaginal antibodies showed a reproducible pattern of reactivity restricted to gp160 and p24. Locally produced anti-env antibodies exhibit reactivity toward the neutralizing ELDKWA epitope of gp41. Study results show that antibodies purified from CVSs block the transcytosis of cell-associated HIV through a tight epithelial monolayer in vitro. These findings suggest that genital resistance to HIV may involve HIV-specific cervicovaginal antibody responses in a minority of highly exposed HIV-seronegative women in association with other protecting factors, such as local production of HIV-suppressive chemokines" @default.
- W2088645908 created "2016-06-24" @default.
- W2088645908 creator A5005751696 @default.
- W2088645908 creator A5006363140 @default.
- W2088645908 creator A5013886026 @default.
- W2088645908 creator A5014511115 @default.
- W2088645908 creator A5016679614 @default.
- W2088645908 creator A5018302038 @default.
- W2088645908 creator A5031275760 @default.
- W2088645908 creator A5036860135 @default.
- W2088645908 creator A5061172065 @default.
- W2088645908 creator A5063507229 @default.
- W2088645908 creator A5063800315 @default.
- W2088645908 creator A5064281122 @default.
- W2088645908 creator A5067498464 @default.
- W2088645908 creator A5079312171 @default.
- W2088645908 creator A5089629404 @default.
- W2088645908 date "2001-12-01" @default.
- W2088645908 modified "2023-09-25" @default.
- W2088645908 title "Cervicovaginal Secretory Antibodies to Human Immunodeficiency Virus Type 1 (HIV‐1) that Block Viral Transcytosis through Tight Epithelial Barriers in Highly Exposed HIV‐1–Seronegative African Women" @default.
- W2088645908 cites W1496700409 @default.
- W2088645908 cites W1506981307 @default.
- W2088645908 cites W1536777415 @default.
- W2088645908 cites W1635348995 @default.
- W2088645908 cites W1799439348 @default.
- W2088645908 cites W1817784777 @default.
- W2088645908 cites W1930641702 @default.
- W2088645908 cites W1953625602 @default.
- W2088645908 cites W1965673179 @default.
- W2088645908 cites W1966756198 @default.
- W2088645908 cites W1980781126 @default.
- W2088645908 cites W1989025673 @default.
- W2088645908 cites W1994810578 @default.
- W2088645908 cites W2023112191 @default.
- W2088645908 cites W2026047595 @default.
- W2088645908 cites W2027858887 @default.
- W2088645908 cites W2045289859 @default.
- W2088645908 cites W2047416802 @default.
- W2088645908 cites W2048999843 @default.
- W2088645908 cites W2058243481 @default.
- W2088645908 cites W2058357901 @default.
- W2088645908 cites W2060447996 @default.
- W2088645908 cites W2062936833 @default.
- W2088645908 cites W2063345756 @default.
- W2088645908 cites W2075712614 @default.
- W2088645908 cites W2078761119 @default.
- W2088645908 cites W2084630434 @default.
- W2088645908 cites W2085114777 @default.
- W2088645908 cites W2088014625 @default.
- W2088645908 cites W2088747167 @default.
- W2088645908 cites W2103059036 @default.
- W2088645908 cites W2107474172 @default.
- W2088645908 cites W2111310175 @default.
- W2088645908 cites W2120697664 @default.
- W2088645908 cites W2121036185 @default.
- W2088645908 cites W2121728508 @default.
- W2088645908 cites W2124409966 @default.
- W2088645908 cites W2136056069 @default.
- W2088645908 cites W2141861391 @default.
- W2088645908 cites W2143329914 @default.
- W2088645908 cites W2156141826 @default.
- W2088645908 cites W2157654243 @default.
- W2088645908 cites W2162007509 @default.
- W2088645908 cites W2171499092 @default.
- W2088645908 cites W2317020409 @default.
- W2088645908 cites W2326396421 @default.
- W2088645908 cites W2327295182 @default.
- W2088645908 cites W80570768 @default.
- W2088645908 doi "https://doi.org/10.1086/324375" @default.
- W2088645908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11709783" @default.
- W2088645908 hasPublicationYear "2001" @default.
- W2088645908 type Work @default.
- W2088645908 sameAs 2088645908 @default.
- W2088645908 citedByCount "103" @default.
- W2088645908 countsByYear W20886459082012 @default.
- W2088645908 countsByYear W20886459082013 @default.
- W2088645908 countsByYear W20886459082014 @default.
- W2088645908 countsByYear W20886459082015 @default.
- W2088645908 countsByYear W20886459082016 @default.
- W2088645908 countsByYear W20886459082017 @default.
- W2088645908 countsByYear W20886459082018 @default.
- W2088645908 countsByYear W20886459082019 @default.
- W2088645908 countsByYear W20886459082020 @default.
- W2088645908 crossrefType "journal-article" @default.
- W2088645908 hasAuthorship W2088645908A5005751696 @default.
- W2088645908 hasAuthorship W2088645908A5006363140 @default.
- W2088645908 hasAuthorship W2088645908A5013886026 @default.
- W2088645908 hasAuthorship W2088645908A5014511115 @default.
- W2088645908 hasAuthorship W2088645908A5016679614 @default.
- W2088645908 hasAuthorship W2088645908A5018302038 @default.
- W2088645908 hasAuthorship W2088645908A5031275760 @default.
- W2088645908 hasAuthorship W2088645908A5036860135 @default.
- W2088645908 hasAuthorship W2088645908A5061172065 @default.
- W2088645908 hasAuthorship W2088645908A5063507229 @default.
- W2088645908 hasAuthorship W2088645908A5063800315 @default.
- W2088645908 hasAuthorship W2088645908A5064281122 @default.
- W2088645908 hasAuthorship W2088645908A5067498464 @default.
- W2088645908 hasAuthorship W2088645908A5079312171 @default.