Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088654326> ?p ?o ?g. }
- W2088654326 endingPage "471" @default.
- W2088654326 startingPage "459" @default.
- W2088654326 abstract "2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitous environmental contaminant that has been shown to alter spatial and visual learning following developmental exposure. The current study examined the effects of gestational and lactational exposure to TCDD on spatial and visual discrimination/reversal learning (spatial and visual RL) in rats using two-lever operant testing chambers. Pregnant Sprague–Dawley rats (10 per dose) received either 0 or 0.1 μg/kg TCDD per orem in corn oil from gestational day (GD) 10 to GD 16. One male and one female from each litter were tested beginning at 100 days of age. For spatial RL, animals were reinforced for pressing the lever associated with the correct spatial location (either left or right). For visual RL, the animals were reinforced for pressing the lever associated with the correct visual stimulus (either the illuminated or nonilluminated cuelight). After reaching 85% correct for two consecutive days, the opposite spatial location or visual cue was reinforced. Five reversals were conducted for spatial RL, and two reversals for visual RL. For spatial RL, there were no differences between the TCDD-exposed and control rats in total number of errors committed. However, an in-depth analysis of errors in four different phases of the learning process revealed that TCDD-exposed rats made more errors early in learning when they were just beginning to learn the new reinforcement contingencies. The importance of this increase in errors during the initial stage of learning is unclear, given that there was no increase in overall errors to criterion. For visual RL, there was a reduction in errors on original learning (OL) for TCDD-exposed males, while TCDD-exposed females exhibited a reduction in errors on the second reversal. Subsequent response pattern analyses revealed that the facilitation in performance was due to a more rapid transition through the early phase of learning. Why males were improved on OL and females were not until the second reversal is unknown, but the different patterns could reflect differences in learning style in male and female rats. In keeping with previous research, the results of the current study underscore the fact that (1) alterations in cognitive function observed following early TCDD exposure are very subtle and (2) under some conditions, learning is actually facilitated, rather than impaired, in TCDD-exposed animals." @default.
- W2088654326 created "2016-06-24" @default.
- W2088654326 creator A5024952055 @default.
- W2088654326 creator A5037070550 @default.
- W2088654326 creator A5070218402 @default.
- W2088654326 creator A5078130206 @default.
- W2088654326 creator A5080382039 @default.
- W2088654326 date "2003-07-01" @default.
- W2088654326 modified "2023-10-16" @default.
- W2088654326 title "Effects of perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on spatial and visual reversal learning in rats" @default.
- W2088654326 cites W1537123837 @default.
- W2088654326 cites W1789363472 @default.
- W2088654326 cites W1965474945 @default.
- W2088654326 cites W1973992648 @default.
- W2088654326 cites W1975796534 @default.
- W2088654326 cites W1991804416 @default.
- W2088654326 cites W1996749941 @default.
- W2088654326 cites W1998298246 @default.
- W2088654326 cites W2006393397 @default.
- W2088654326 cites W2020183253 @default.
- W2088654326 cites W2027058846 @default.
- W2088654326 cites W2046713629 @default.
- W2088654326 cites W2058640886 @default.
- W2088654326 cites W2060812714 @default.
- W2088654326 cites W2063079732 @default.
- W2088654326 cites W2065893837 @default.
- W2088654326 cites W2066186736 @default.
- W2088654326 cites W2072847027 @default.
- W2088654326 cites W2073939765 @default.
- W2088654326 cites W2077072895 @default.
- W2088654326 cites W2081336408 @default.
- W2088654326 cites W2090652492 @default.
- W2088654326 cites W2092387347 @default.
- W2088654326 cites W2109756230 @default.
- W2088654326 cites W2123381157 @default.
- W2088654326 cites W2155243943 @default.
- W2088654326 cites W4234685833 @default.
- W2088654326 cites W4252473416 @default.
- W2088654326 doi "https://doi.org/10.1016/s0892-0362(03)00014-x" @default.
- W2088654326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12798963" @default.
- W2088654326 hasPublicationYear "2003" @default.
- W2088654326 type Work @default.
- W2088654326 sameAs 2088654326 @default.
- W2088654326 citedByCount "51" @default.
- W2088654326 countsByYear W20886543262012 @default.
- W2088654326 countsByYear W20886543262013 @default.
- W2088654326 countsByYear W20886543262014 @default.
- W2088654326 countsByYear W20886543262015 @default.
- W2088654326 countsByYear W20886543262016 @default.
- W2088654326 countsByYear W20886543262017 @default.
- W2088654326 countsByYear W20886543262018 @default.
- W2088654326 countsByYear W20886543262019 @default.
- W2088654326 countsByYear W20886543262020 @default.
- W2088654326 countsByYear W20886543262021 @default.
- W2088654326 crossrefType "journal-article" @default.
- W2088654326 hasAuthorship W2088654326A5024952055 @default.
- W2088654326 hasAuthorship W2088654326A5037070550 @default.
- W2088654326 hasAuthorship W2088654326A5070218402 @default.
- W2088654326 hasAuthorship W2088654326A5078130206 @default.
- W2088654326 hasAuthorship W2088654326A5080382039 @default.
- W2088654326 hasConcept C107524782 @default.
- W2088654326 hasConcept C121332964 @default.
- W2088654326 hasConcept C138496976 @default.
- W2088654326 hasConcept C15744967 @default.
- W2088654326 hasConcept C169760540 @default.
- W2088654326 hasConcept C169900460 @default.
- W2088654326 hasConcept C180747234 @default.
- W2088654326 hasConcept C2779918689 @default.
- W2088654326 hasConcept C2985665543 @default.
- W2088654326 hasConcept C42407357 @default.
- W2088654326 hasConcept C548259974 @default.
- W2088654326 hasConcept C62520636 @default.
- W2088654326 hasConcept C67203356 @default.
- W2088654326 hasConcept C71924100 @default.
- W2088654326 hasConcept C77805123 @default.
- W2088654326 hasConceptScore W2088654326C107524782 @default.
- W2088654326 hasConceptScore W2088654326C121332964 @default.
- W2088654326 hasConceptScore W2088654326C138496976 @default.
- W2088654326 hasConceptScore W2088654326C15744967 @default.
- W2088654326 hasConceptScore W2088654326C169760540 @default.
- W2088654326 hasConceptScore W2088654326C169900460 @default.
- W2088654326 hasConceptScore W2088654326C180747234 @default.
- W2088654326 hasConceptScore W2088654326C2779918689 @default.
- W2088654326 hasConceptScore W2088654326C2985665543 @default.
- W2088654326 hasConceptScore W2088654326C42407357 @default.
- W2088654326 hasConceptScore W2088654326C548259974 @default.
- W2088654326 hasConceptScore W2088654326C62520636 @default.
- W2088654326 hasConceptScore W2088654326C67203356 @default.
- W2088654326 hasConceptScore W2088654326C71924100 @default.
- W2088654326 hasConceptScore W2088654326C77805123 @default.
- W2088654326 hasIssue "4" @default.
- W2088654326 hasLocation W20886543261 @default.
- W2088654326 hasLocation W20886543262 @default.
- W2088654326 hasOpenAccess W2088654326 @default.
- W2088654326 hasPrimaryLocation W20886543261 @default.
- W2088654326 hasRelatedWork W1993507265 @default.
- W2088654326 hasRelatedWork W2031514913 @default.
- W2088654326 hasRelatedWork W2095485198 @default.