FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088654830> ?p ?o ?g. }

• W2088654830 endingPage "3581" @default.
• W2088654830 startingPage "3572" @default.
• W2088654830 abstract "IL-12 and IL-23, which share the IL-12 p40 subunit, have been ascribed central roles in many autoimmune disorders. We describe here an anti-IL-12 (αIL-12) auto-vaccine that potentially blocks both factors in vivo. Immunization of mice with mouse IL-12 coupled to OVA or Pan DR epitope (PADRE) peptide induced Ab directed against the IL-12 p40 subunit, which prevented IFN-γ production in response to IL-12 administration in vivo. Experimental autoimmune encephalomyelitis, an IL-23-dependent disease model, induced in SJL mice with a proteolipid protein (PLP) peptide was almost undetectable after αIL-12 vaccination. Myelin oligodendrocyte glycoprotein (MOG)-induced disease in C57BL/6 mice was also significantly inhibited. This protection correlated with inhibited Th1 cytokine responses in vitro and with an increase in the IgG1/IgG2a anti-PLP Ab balance. Detrimental consequences of αIL-12 vaccination were evaluated in C57BL/6 mice infected with Leishmania major (L.m.). While delayed-type hypersensitivity (DTH) suppression and immunoglobulin as well as interleukin production patterns reflected a major shift toward a Th2-type response, L.m. growth was still significantly retarded as compared to that seen in susceptible BALB/c mice. However, vaccinated animals ultimately failed to control parasite expansion. These results suggest that some chronic autoimmune diseases may benefit from αIL-12 vaccination at the expense of reduced, but not completely abrogated, cell-mediated immunity." @default.
• W2088654830 created "2016-06-24" @default.
• W2088654830 creator A5008565163 @default.
• W2088654830 creator A5047585572 @default.
• W2088654830 creator A5048518247 @default.
• W2088654830 creator A5059160872 @default.
• W2088654830 creator A5082890715 @default.
• W2088654830 date "2004-12-01" @default.
• W2088654830 modified "2023-10-18" @default.
• W2088654830 title "Development of an anti-IL-12 p40 auto-vaccine: protection in experimental autoimmune encephalomyelitis at the expense of increased sensitivity to infection" @default.
• W2088654830 cites W1480063099 @default.
• W2088654830 cites W1495660214 @default.
• W2088654830 cites W1560613345 @default.
• W2088654830 cites W1561485846 @default.
• W2088654830 cites W1567963426 @default.
• W2088654830 cites W1585156290 @default.
• W2088654830 cites W1600644905 @default.
• W2088654830 cites W1773775383 @default.
• W2088654830 cites W1969411212 @default.
• W2088654830 cites W1973198631 @default.
• W2088654830 cites W1974301912 @default.
• W2088654830 cites W1975881881 @default.
• W2088654830 cites W1981859543 @default.
• W2088654830 cites W1982752226 @default.
• W2088654830 cites W1990848100 @default.
• W2088654830 cites W1997999969 @default.
• W2088654830 cites W1998132604 @default.
• W2088654830 cites W1998199590 @default.
• W2088654830 cites W2016584625 @default.
• W2088654830 cites W2017684091 @default.
• W2088654830 cites W2026218766 @default.
• W2088654830 cites W2030407028 @default.
• W2088654830 cites W2035261951 @default.
• W2088654830 cites W2067877107 @default.
• W2088654830 cites W2072839721 @default.
• W2088654830 cites W2076889715 @default.
• W2088654830 cites W2079242778 @default.
• W2088654830 cites W2089589689 @default.
• W2088654830 cites W2104032278 @default.
• W2088654830 cites W2109830199 @default.
• W2088654830 cites W2112434543 @default.
• W2088654830 cites W2117079340 @default.
• W2088654830 cites W2121060291 @default.
• W2088654830 cites W2124072977 @default.
• W2088654830 cites W2141679700 @default.
• W2088654830 cites W2144829410 @default.
• W2088654830 cites W2145699341 @default.
• W2088654830 cites W2149160053 @default.
• W2088654830 cites W2152803371 @default.
• W2088654830 cites W2154096824 @default.
• W2088654830 cites W2171463669 @default.
• W2088654830 cites W4239945583 @default.
• W2088654830 cites W4313305992 @default.
• W2088654830 cites W4313306017 @default.
• W2088654830 doi "https://doi.org/10.1002/eji.200425443" @default.
• W2088654830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15549728" @default.
• W2088654830 hasPublicationYear "2004" @default.
• W2088654830 type Work @default.
• W2088654830 sameAs 2088654830 @default.
• W2088654830 citedByCount "38" @default.
• W2088654830 countsByYear W20886548302012 @default.
• W2088654830 countsByYear W20886548302014 @default.
• W2088654830 countsByYear W20886548302015 @default.
• W2088654830 countsByYear W20886548302016 @default.
• W2088654830 countsByYear W20886548302017 @default.
• W2088654830 countsByYear W20886548302018 @default.
• W2088654830 countsByYear W20886548302019 @default.
• W2088654830 countsByYear W20886548302020 @default.
• W2088654830 countsByYear W20886548302021 @default.
• W2088654830 crossrefType "journal-article" @default.
• W2088654830 hasAuthorship W2088654830A5008565163 @default.
• W2088654830 hasAuthorship W2088654830A5047585572 @default.
• W2088654830 hasAuthorship W2088654830A5048518247 @default.
• W2088654830 hasAuthorship W2088654830A5059160872 @default.
• W2088654830 hasAuthorship W2088654830A5082890715 @default.
• W2088654830 hasBestOaLocation W20886548301 @default.
• W2088654830 hasConcept C134018914 @default.
• W2088654830 hasConcept C159654299 @default.
• W2088654830 hasConcept C203014093 @default.
• W2088654830 hasConcept C22070199 @default.
• W2088654830 hasConcept C2778486448 @default.
• W2088654830 hasConcept C2778609137 @default.
• W2088654830 hasConcept C2778690821 @default.
• W2088654830 hasConcept C2779075594 @default.
• W2088654830 hasConcept C2779341262 @default.
• W2088654830 hasConcept C2779357208 @default.
• W2088654830 hasConcept C2780801004 @default.
• W2088654830 hasConcept C2780876595 @default.
• W2088654830 hasConcept C529278444 @default.
• W2088654830 hasConcept C7821365 @default.
• W2088654830 hasConcept C86803240 @default.
• W2088654830 hasConcept C8891405 @default.
• W2088654830 hasConceptScore W2088654830C134018914 @default.
• W2088654830 hasConceptScore W2088654830C159654299 @default.
• W2088654830 hasConceptScore W2088654830C203014093 @default.
• W2088654830 hasConceptScore W2088654830C22070199 @default.
• W2088654830 hasConceptScore W2088654830C2778486448 @default.
• W2088654830 hasConceptScore W2088654830C2778609137 @default.

• next