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- W2088659831 abstract "Monoclonal antibodies (mAbs) have become an important addition to chemo- and/or radiotherapy for the treatment of cancer. They have multiple effector functions that can lead to eradication of tumor, including induction of apoptosis, growth inhibition, and initiation of complement-dependent lysis. Furthermore, mAbs can recruit immune effector cells. Traditionally, natural killer cells have been considered as the main effector cell population in mAb-mediated tumor killing. Myeloid cells have potent cytotoxic ability, as well. Monocytes and macrophages have been shown to induce antibody-dependent cytotoxicity and phagocytosis of tumor cells in the presence of IgG anti-tumor mAb. Furthermore, neutrophils are the most abundant population of circulating white blood cells, and as such may constitute a formidable source of effector cells. However, when targeting neutrophils for tumor therapy, antibodies of the IgA subclass may be more effective. This article focuses on enlisting myeloid effector cells for mAb-based immunotherapy of cancer. Additionally, methods to study mAb-dependent phagocytosis of tumor cells by macrophages are compared." @default.
- W2088659831 created "2016-06-24" @default.
- W2088659831 creator A5051015262 @default.
- W2088659831 creator A5071723323 @default.
- W2088659831 creator A5090198296 @default.
- W2088659831 date "2014-01-01" @default.
- W2088659831 modified "2023-10-18" @default.
- W2088659831 title "Myeloid cells as effector cells for monoclonal antibody therapy of cancer" @default.
- W2088659831 cites W110631719 @default.
- W2088659831 cites W1516451902 @default.
- W2088659831 cites W1518549789 @default.
- W2088659831 cites W1562082546 @default.
- W2088659831 cites W1593874097 @default.
- W2088659831 cites W1609910491 @default.
- W2088659831 cites W1610114835 @default.
- W2088659831 cites W1619850380 @default.
- W2088659831 cites W1658565633 @default.
- W2088659831 cites W1675831178 @default.
- W2088659831 cites W1733046501 @default.
- W2088659831 cites W1797422316 @default.
- W2088659831 cites W1808109212 @default.
- W2088659831 cites W1903287340 @default.
- W2088659831 cites W1930879408 @default.
- W2088659831 cites W1942966726 @default.
- W2088659831 cites W1947298690 @default.
- W2088659831 cites W1952288345 @default.
- W2088659831 cites W1965205681 @default.
- W2088659831 cites W1965962344 @default.
- W2088659831 cites W1966217032 @default.
- W2088659831 cites W1969771214 @default.
- W2088659831 cites W1972932010 @default.
- W2088659831 cites W1973036556 @default.
- W2088659831 cites W1987591286 @default.
- W2088659831 cites W1988264764 @default.
- W2088659831 cites W1989797477 @default.
- W2088659831 cites W1991629081 @default.
- W2088659831 cites W1994823455 @default.
- W2088659831 cites W1998911252 @default.
- W2088659831 cites W2000276387 @default.
- W2088659831 cites W2001570963 @default.
- W2088659831 cites W2002157461 @default.
- W2088659831 cites W2003120234 @default.
- W2088659831 cites W2005519719 @default.
- W2088659831 cites W2006885022 @default.
- W2088659831 cites W2010690292 @default.
- W2088659831 cites W2010690729 @default.
- W2088659831 cites W2012719421 @default.
- W2088659831 cites W2015567053 @default.
- W2088659831 cites W2015795968 @default.
- W2088659831 cites W2020397881 @default.
- W2088659831 cites W2024547239 @default.
- W2088659831 cites W2025381786 @default.
- W2088659831 cites W2028928436 @default.
- W2088659831 cites W2029744434 @default.
- W2088659831 cites W2032202611 @default.
- W2088659831 cites W2035185781 @default.
- W2088659831 cites W2041944580 @default.
- W2088659831 cites W2042995283 @default.
- W2088659831 cites W2043228552 @default.
- W2088659831 cites W2043982856 @default.
- W2088659831 cites W2047832163 @default.
- W2088659831 cites W2049000257 @default.
- W2088659831 cites W2050405695 @default.
- W2088659831 cites W2051699257 @default.
- W2088659831 cites W2052374585 @default.
- W2088659831 cites W2054472394 @default.
- W2088659831 cites W2057745345 @default.
- W2088659831 cites W2058342634 @default.
- W2088659831 cites W2058409344 @default.
- W2088659831 cites W2067400349 @default.
- W2088659831 cites W2068367973 @default.
- W2088659831 cites W2068553332 @default.
- W2088659831 cites W2077929615 @default.
- W2088659831 cites W2078060454 @default.
- W2088659831 cites W2078444317 @default.
- W2088659831 cites W2079588331 @default.
- W2088659831 cites W2081278295 @default.
- W2088659831 cites W2082849642 @default.
- W2088659831 cites W2083517547 @default.
- W2088659831 cites W2084906660 @default.
- W2088659831 cites W2089881927 @default.
- W2088659831 cites W2091133773 @default.
- W2088659831 cites W2092246736 @default.
- W2088659831 cites W2092282847 @default.
- W2088659831 cites W2093785176 @default.
- W2088659831 cites W2104934425 @default.
- W2088659831 cites W2106545303 @default.
- W2088659831 cites W2108556253 @default.
- W2088659831 cites W2109440389 @default.
- W2088659831 cites W2110990893 @default.
- W2088659831 cites W2112940058 @default.
- W2088659831 cites W2122080125 @default.
- W2088659831 cites W2122618533 @default.
- W2088659831 cites W2122786380 @default.
- W2088659831 cites W2126204744 @default.
- W2088659831 cites W2127386794 @default.
- W2088659831 cites W2128231474 @default.
- W2088659831 cites W2128402413 @default.