Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088676274> ?p ?o ?g. }
- W2088676274 endingPage "137" @default.
- W2088676274 startingPage "123" @default.
- W2088676274 abstract "Activins are a closely related subgroup within the TGFβ superfamily of growth and differentiation factors. They consist of two disulfide-linked β subunits. Four mammalian activin β subunits termed βA, βB, βC, and βE, respectively, have been identified. Activin A, the homodimer of two βA subunits, has important regulatory functions in reproductive biology, embryonic development, inflammation, and tissue repair. Several intra- and extracellular antagonists, including the activin-binding proteins follistatin and follistatin-related protein, serve to fine-tune activin A activity. In the liver there is compelling evidence that activin A is involved in the regulation of cell number by inhibition of hepatocyte replication and induction of apoptosis. In addition, activin A stimulates extracellular matrix production in hepatic stellate cells and tubulogenesis of sinusoidal endothelial cells, and thus contributes to restoration of tissue architecture during liver regeneration. Accumulating evidence from animal models and from patient data suggests that deregulation of activin A signaling contributes to pathologic conditions such as hepatic inflammation and fibrosis, acute liver failure, and development of liver cancer. Increased production of activin A was suggested to be a contributing factor to impaired hepatocyte regeneration in acute liver failure and to overproduction of extracellular matrix in liver fibrosis. Recent evidence suggests that escape of (pre)neoplastic hepatocytes from growth control by activin A through overexpression of follistatin and reduced activin production contributes to hepatocarcinogenesis. The role of the activin subunits βC and βE, which are both highly expressed in hepatocytes, is still quite incompletely understood. Down-regulation in liver tumors and a growth inhibitory function similar to that of βA has been shown for βE. Contradictory results with regard to cell proliferation have been reported for βC. The profound involvement of the activin axis in liver biology and in the pathogenesis of severe hepatic diseases suggests activin as potential target for therapeutic interventions." @default.
- W2088676274 created "2016-06-24" @default.
- W2088676274 creator A5001054513 @default.
- W2088676274 creator A5033125669 @default.
- W2088676274 creator A5043913136 @default.
- W2088676274 creator A5048720978 @default.
- W2088676274 creator A5061812803 @default.
- W2088676274 creator A5069497312 @default.
- W2088676274 creator A5079301073 @default.
- W2088676274 creator A5091627591 @default.
- W2088676274 date "2006-11-01" @default.
- W2088676274 modified "2023-10-06" @default.
- W2088676274 title "The activin axis in liver biology and disease" @default.
- W2088676274 cites W1513850687 @default.
- W2088676274 cites W1568657070 @default.
- W2088676274 cites W1570507925 @default.
- W2088676274 cites W1572229681 @default.
- W2088676274 cites W1644456199 @default.
- W2088676274 cites W1663371441 @default.
- W2088676274 cites W1666089077 @default.
- W2088676274 cites W1851446342 @default.
- W2088676274 cites W1885916346 @default.
- W2088676274 cites W1903013422 @default.
- W2088676274 cites W1969989929 @default.
- W2088676274 cites W1973525889 @default.
- W2088676274 cites W1973693249 @default.
- W2088676274 cites W1974316934 @default.
- W2088676274 cites W1974602537 @default.
- W2088676274 cites W1975681855 @default.
- W2088676274 cites W1977151351 @default.
- W2088676274 cites W1977410508 @default.
- W2088676274 cites W1978094332 @default.
- W2088676274 cites W1978834902 @default.
- W2088676274 cites W1979633357 @default.
- W2088676274 cites W1980060975 @default.
- W2088676274 cites W1980333534 @default.
- W2088676274 cites W1980923999 @default.
- W2088676274 cites W1981419171 @default.
- W2088676274 cites W1982972370 @default.
- W2088676274 cites W1986505353 @default.
- W2088676274 cites W1991046191 @default.
- W2088676274 cites W1992048287 @default.
- W2088676274 cites W1992740170 @default.
- W2088676274 cites W1992768239 @default.
- W2088676274 cites W1995048704 @default.
- W2088676274 cites W1996009590 @default.
- W2088676274 cites W1997998703 @default.
- W2088676274 cites W1998374567 @default.
- W2088676274 cites W1998420703 @default.
- W2088676274 cites W1999061629 @default.
- W2088676274 cites W2000991526 @default.
- W2088676274 cites W2001183029 @default.
- W2088676274 cites W2004332684 @default.
- W2088676274 cites W2007209694 @default.
- W2088676274 cites W2007333291 @default.
- W2088676274 cites W2008461201 @default.
- W2088676274 cites W2008847331 @default.
- W2088676274 cites W2011225961 @default.
- W2088676274 cites W2011334059 @default.
- W2088676274 cites W2011775394 @default.
- W2088676274 cites W2013014303 @default.
- W2088676274 cites W2015314992 @default.
- W2088676274 cites W2016068055 @default.
- W2088676274 cites W2019400355 @default.
- W2088676274 cites W2022266496 @default.
- W2088676274 cites W2024689808 @default.
- W2088676274 cites W2025123418 @default.
- W2088676274 cites W2028854652 @default.
- W2088676274 cites W2029735349 @default.
- W2088676274 cites W2029842228 @default.
- W2088676274 cites W2031399745 @default.
- W2088676274 cites W2033249901 @default.
- W2088676274 cites W2034269086 @default.
- W2088676274 cites W2036453314 @default.
- W2088676274 cites W2036509369 @default.
- W2088676274 cites W2037629418 @default.
- W2088676274 cites W2045365545 @default.
- W2088676274 cites W2047245032 @default.
- W2088676274 cites W2047569772 @default.
- W2088676274 cites W2049452537 @default.
- W2088676274 cites W2050242151 @default.
- W2088676274 cites W2050620572 @default.
- W2088676274 cites W2054413652 @default.
- W2088676274 cites W2054684099 @default.
- W2088676274 cites W2058915390 @default.
- W2088676274 cites W2059147394 @default.
- W2088676274 cites W2059373933 @default.
- W2088676274 cites W2060889469 @default.
- W2088676274 cites W2062474027 @default.
- W2088676274 cites W2066071415 @default.
- W2088676274 cites W2068756636 @default.
- W2088676274 cites W2070055015 @default.
- W2088676274 cites W2074609262 @default.
- W2088676274 cites W2076376185 @default.
- W2088676274 cites W2077243848 @default.
- W2088676274 cites W2078833989 @default.
- W2088676274 cites W2079155618 @default.
- W2088676274 cites W2079325666 @default.