Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088693792> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2088693792 abstract "We describe a method for modeling organization of the interphase nucleus, and its application to polytene chromosomes of Drosophila salivary glands. The model represents chromosomes as polymer chains confined within the nucleus. Physical parameters of the model are taken directly from experiment, no fitting parameters are introduced. The model is used to simulate chromosome tracing experiments. When applied to previously published data 33 new chromosome_nuclear envelope (Chr-NE) contacts are revealed. Most of these new Chr-NE contacts correspond to intercalary heterochromatin - gene poor, dark staining, late replicating regions of the genome; only three correspond to euchromatin - gene rich, light staining, early replicating regions of the genome. Analysis of regions least likely to form Chr-NE contacts reveals that these are mostly euchromatic, but may contain late replication regions or intercalary heterochromatin. We show that Chr-NE contacts may affect long range gene-gene interactions: depending on the chromosome contour length between two contacts, gene-gene interaction probability may increase or decrease. We also develop methods to objectively quantify chromosome territories and intertwining and discuss the corresponding experimental observations.View Large Image | View Hi-Res Image | Download PowerPoint Slide" @default.
- W2088693792 created "2016-06-24" @default.
- W2088693792 creator A5022075325 @default.
- W2088693792 creator A5045411526 @default.
- W2088693792 creator A5048174967 @default.
- W2088693792 date "2013-01-01" @default.
- W2088693792 modified "2023-09-28" @default.
- W2088693792 title "A Model of Nuclear Organization Demonstrates the Effect of Nuclear Envelope - Chromosome Contacts on 3D Organization of Chromosomes" @default.
- W2088693792 doi "https://doi.org/10.1016/j.bpj.2012.11.3056" @default.
- W2088693792 hasPublicationYear "2013" @default.
- W2088693792 type Work @default.
- W2088693792 sameAs 2088693792 @default.
- W2088693792 citedByCount "0" @default.
- W2088693792 crossrefType "journal-article" @default.
- W2088693792 hasAuthorship W2088693792A5022075325 @default.
- W2088693792 hasAuthorship W2088693792A5045411526 @default.
- W2088693792 hasAuthorship W2088693792A5048174967 @default.
- W2088693792 hasBestOaLocation W20886937921 @default.
- W2088693792 hasConcept C100924687 @default.
- W2088693792 hasConcept C103435993 @default.
- W2088693792 hasConcept C104317684 @default.
- W2088693792 hasConcept C141231307 @default.
- W2088693792 hasConcept C163096569 @default.
- W2088693792 hasConcept C174600577 @default.
- W2088693792 hasConcept C30481170 @default.
- W2088693792 hasConcept C51423104 @default.
- W2088693792 hasConcept C54355233 @default.
- W2088693792 hasConcept C86803240 @default.
- W2088693792 hasConceptScore W2088693792C100924687 @default.
- W2088693792 hasConceptScore W2088693792C103435993 @default.
- W2088693792 hasConceptScore W2088693792C104317684 @default.
- W2088693792 hasConceptScore W2088693792C141231307 @default.
- W2088693792 hasConceptScore W2088693792C163096569 @default.
- W2088693792 hasConceptScore W2088693792C174600577 @default.
- W2088693792 hasConceptScore W2088693792C30481170 @default.
- W2088693792 hasConceptScore W2088693792C51423104 @default.
- W2088693792 hasConceptScore W2088693792C54355233 @default.
- W2088693792 hasConceptScore W2088693792C86803240 @default.
- W2088693792 hasLocation W20886937921 @default.
- W2088693792 hasOpenAccess W2088693792 @default.
- W2088693792 hasPrimaryLocation W20886937921 @default.
- W2088693792 hasRelatedWork W139426192 @default.
- W2088693792 hasRelatedWork W1977472233 @default.
- W2088693792 hasRelatedWork W2005644622 @default.
- W2088693792 hasRelatedWork W2005944417 @default.
- W2088693792 hasRelatedWork W2008301352 @default.
- W2088693792 hasRelatedWork W2008596609 @default.
- W2088693792 hasRelatedWork W2051947938 @default.
- W2088693792 hasRelatedWork W2060228572 @default.
- W2088693792 hasRelatedWork W2097637232 @default.
- W2088693792 hasRelatedWork W2109000324 @default.
- W2088693792 hasRelatedWork W2153148487 @default.
- W2088693792 hasRelatedWork W2154920408 @default.
- W2088693792 hasRelatedWork W2170516826 @default.
- W2088693792 hasRelatedWork W2262832127 @default.
- W2088693792 hasRelatedWork W2335398864 @default.
- W2088693792 hasRelatedWork W2428971806 @default.
- W2088693792 hasRelatedWork W2580741166 @default.
- W2088693792 hasRelatedWork W2802855755 @default.
- W2088693792 hasRelatedWork W3176460472 @default.
- W2088693792 hasRelatedWork W3206494379 @default.
- W2088693792 isParatext "false" @default.
- W2088693792 isRetracted "false" @default.
- W2088693792 magId "2088693792" @default.
- W2088693792 workType "article" @default.