FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088695744> ?p ?o ?g. }

• W2088695744 endingPage "e0120403" @default.
• W2088695744 startingPage "e0120403" @default.
• W2088695744 abstract "Currently, genotyping of patients for polymorphic enzymes responsible for metabolic elimination is considered a possibility to adjust drug dose levels. For a patient to profit from this procedure, the interindividual differences in drug metabolism within one genotype should be smaller than those between different genotypes. We studied a large cohort of healthy young adults (283 subjects), correlating their CYP2C9 genotype to a simple phenotyping metric, using flurbiprofen as probe drug. Genotyping was conducted for CYP2C9*1, *2, *3. The urinary metabolic ratio MR (concentration of CYP2C9-dependent metabolite divided by concentration of flurbiprofen) determined two hours after flurbiprofen (8.75 mg) administration served as phenotyping metric. Linear statistical models correlating genotype and phenotype provided highly significant allele-specific MR estimates of 0.596 for the wild type allele CYP2C9*1, 0.405 for CYP2C9*2 (68 % of wild type), and 0.113 for CYP2C9*3 (19 % of wild type). If these estimates were used for flurbiprofen dose adjustment, taking 100 % for genotype *1/*1, an average reduction to 84 %, 60 %, 68 %, 43 %, and 19 % would result for genotype *1/*2, *1/*3, *2/*2, *2/*3, and *3/*3, respectively. Due to the large individual variation within genotypes with coefficients of variation ≥ 20 % and supposing the normal distribution, one in three individuals would be out of the average optimum dose by more than 20 %, one in 20 would be 40 % off. Whether this problem also applies to other CYPs and other drugs has to be investigated case by case. Our data for the given example, however, puts the benefit of individual drug dosing to question, if it is exclusively based on genotype." @default.
• W2088695744 created "2016-06-24" @default.
• W2088695744 creator A5005156167 @default.
• W2088695744 creator A5021809780 @default.
• W2088695744 creator A5023022293 @default.
• W2088695744 creator A5038959929 @default.
• W2088695744 date "2015-03-16" @default.
• W2088695744 modified "2023-10-14" @default.
• W2088695744 title "CYP2C9 Genotype vs. Metabolic Phenotype for Individual Drug Dosing—A Correlation Analysis Using Flurbiprofen as Probe Drug" @default.
• W2088695744 cites W179252842 @default.
• W2088695744 cites W195154118 @default.
• W2088695744 cites W1974766025 @default.
• W2088695744 cites W1978892904 @default.
• W2088695744 cites W1988374486 @default.
• W2088695744 cites W2002294528 @default.
• W2088695744 cites W2002779112 @default.
• W2088695744 cites W2007848784 @default.
• W2088695744 cites W2009045710 @default.
• W2088695744 cites W2024148791 @default.
• W2088695744 cites W2033631256 @default.
• W2088695744 cites W2039500477 @default.
• W2088695744 cites W2041501033 @default.
• W2088695744 cites W2054658335 @default.
• W2088695744 cites W2062404230 @default.
• W2088695744 cites W2068602483 @default.
• W2088695744 cites W2070536631 @default.
• W2088695744 cites W2079571096 @default.
• W2088695744 cites W2099046070 @default.
• W2088695744 cites W2101265962 @default.
• W2088695744 cites W2105679362 @default.
• W2088695744 cites W2109453128 @default.
• W2088695744 cites W2112275381 @default.
• W2088695744 cites W2117771590 @default.
• W2088695744 cites W2124396464 @default.
• W2088695744 cites W2130986374 @default.
• W2088695744 cites W2136965458 @default.
• W2088695744 cites W2139090295 @default.
• W2088695744 cites W2144716902 @default.
• W2088695744 cites W2145759756 @default.
• W2088695744 cites W2151480705 @default.
• W2088695744 cites W2151774137 @default.
• W2088695744 cites W2167473711 @default.
• W2088695744 cites W2167556400 @default.
• W2088695744 cites W2363630587 @default.
• W2088695744 cites W9190291 @default.
• W2088695744 doi "https://doi.org/10.1371/journal.pone.0120403" @default.
• W2088695744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4395445" @default.
• W2088695744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25875957" @default.
• W2088695744 hasPublicationYear "2015" @default.
• W2088695744 type Work @default.
• W2088695744 sameAs 2088695744 @default.
• W2088695744 citedByCount "17" @default.
• W2088695744 countsByYear W20886957442015 @default.
• W2088695744 countsByYear W20886957442016 @default.
• W2088695744 countsByYear W20886957442018 @default.
• W2088695744 countsByYear W20886957442019 @default.
• W2088695744 countsByYear W20886957442020 @default.
• W2088695744 countsByYear W20886957442021 @default.
• W2088695744 countsByYear W20886957442022 @default.
• W2088695744 crossrefType "journal-article" @default.
• W2088695744 hasAuthorship W2088695744A5005156167 @default.
• W2088695744 hasAuthorship W2088695744A5021809780 @default.
• W2088695744 hasAuthorship W2088695744A5023022293 @default.
• W2088695744 hasAuthorship W2088695744A5038959929 @default.
• W2088695744 hasBestOaLocation W20886957441 @default.
• W2088695744 hasConcept C104317684 @default.
• W2088695744 hasConcept C126322002 @default.
• W2088695744 hasConcept C134018914 @default.
• W2088695744 hasConcept C135763542 @default.
• W2088695744 hasConcept C149737253 @default.
• W2088695744 hasConcept C180754005 @default.
• W2088695744 hasConcept C2777477808 @default.
• W2088695744 hasConcept C2781000538 @default.
• W2088695744 hasConcept C31467283 @default.
• W2088695744 hasConcept C3946865 @default.
• W2088695744 hasConcept C54355233 @default.
• W2088695744 hasConcept C55775858 @default.
• W2088695744 hasConcept C71924100 @default.
• W2088695744 hasConcept C86803240 @default.
• W2088695744 hasConcept C98274493 @default.
• W2088695744 hasConceptScore W2088695744C104317684 @default.
• W2088695744 hasConceptScore W2088695744C126322002 @default.
• W2088695744 hasConceptScore W2088695744C134018914 @default.
• W2088695744 hasConceptScore W2088695744C135763542 @default.
• W2088695744 hasConceptScore W2088695744C149737253 @default.
• W2088695744 hasConceptScore W2088695744C180754005 @default.
• W2088695744 hasConceptScore W2088695744C2777477808 @default.
• W2088695744 hasConceptScore W2088695744C2781000538 @default.
• W2088695744 hasConceptScore W2088695744C31467283 @default.
• W2088695744 hasConceptScore W2088695744C3946865 @default.
• W2088695744 hasConceptScore W2088695744C54355233 @default.
• W2088695744 hasConceptScore W2088695744C55775858 @default.
• W2088695744 hasConceptScore W2088695744C71924100 @default.
• W2088695744 hasConceptScore W2088695744C86803240 @default.
• W2088695744 hasConceptScore W2088695744C98274493 @default.
• W2088695744 hasIssue "3" @default.
• W2088695744 hasLocation W20886957441 @default.
• W2088695744 hasLocation W20886957442 @default.

• next