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• W2088696515 endingPage "657" @default.
• W2088696515 startingPage "648" @default.
• W2088696515 abstract "Adenylyl cyclase (AC) activity is ubiquitous in mammalian cells, and various forms of this enzyme exist that widely differ with regard to tissue distribution, abundance, and modes of regulation. Human placenta is made, among others, of cytotrophoblast cells and syncytiotrophoblasts. This latter is a polynucleate structure that originates from the differentiation of proliferative mononucleated cytotrophoblast cells, the placental stem cell, into syncytiotrophoblasts. In vitro, this differentiation process is associated with a concomitant increase in cellular levels of cAMP and enhanced expression of genes representative of syncytiotrophoblasts endocrine activity. Thus, in this study we evaluated the differential distribution of AC isoforms in cytotrophoblast cells and syncytiotrophoblasts by reverse transcription-polymerase chain reaction (RT-PCR) using total RNA or purified mRNA. Our results demonstrate that all membrane and soluble AC mRNA isoforms are present in both cell types. Interestingly in syncytiotrophoblasts, AC4 and AC8 mRNA are highly expressed, while AC1, AC2 mRNA are less abundant when compared to cytotrophoblast cells. Additionally, the soluble AC is expressed in both trophoblast cells, but its expression is greatly reduced in differentiated cells, syncytiotrophoblasts. The presence of these AC proteins in both cells was confirmed by Western blotting. Taken together, these data help us to characterize the different AC isoforms in human cytotrophoblast cells and syncytiotrophoblasts, and demonstrate that the AC isoforms expression seems to be mainly modulated in groups 1 and 2. Moreover, the important decrease of the soluble AC isoform in syncytiotrophoblasts as compared to cytotrophoblast cells could suggest an important role of this AC in the extravillous trophoblast formation." @default.
• W2088696515 created "2016-06-24" @default.
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• W2088696515 date "2003-07-01" @default.
• W2088696515 modified "2023-10-02" @default.
• W2088696515 title "Differential Expression of Membrane and Soluble Adenylyl Cyclase Isoforms in Cytotrophoblast Cells and Syncytiotrophoblasts of Human Placenta" @default.
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• W2088696515 doi "https://doi.org/10.1016/s0143-4004(03)00060-2" @default.
• W2088696515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12828923" @default.
• W2088696515 hasPublicationYear "2003" @default.
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