Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088697902> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2088697902 endingPage "6292" @default.
- W2088697902 startingPage "6288" @default.
- W2088697902 abstract "Several tumors have been reported to down-regulate expression of their class I major histocompatibility molecules, potentially altering their immune recognition. To investigate this phenomenon, we are using various sublines isolated from the S49 lymphoma of the BALB/c mouse strain. These S49 tumor sublines were previously found to have shut off expression of their Kd, Dd, and/or Ld class I molecules in a locus-specific manner. Extensive Southern blot analyses indicated that there were no major chromosome aberrancies in these S49 sublines, and analyses of steady-state class I mRNA suggested that a form of transcriptional regulation was responsible for their variant class I expression. In this report, we characterize the nature of this locus-specific regulation of class I in S49 cells by producing somatic cell hybrids. Three phenotypically distinct S49 sublines were each fused to tumor cells with normal class I expression, and several of the resulting hybrids were analyzed. In every case, the class I molecules expressed by the hybrids were an exact composite of the two fusion partners. Thus, these fusions failed to rescue expression of the Kd, Dd, and/or Ld molecules shut off within each of the S49 tumor sublines. These findings indicate that this locus-specific shutoff of class I expression results from a cis-acting defect and not trans-acting factors. Because the analysis of each of three phenotypically different S49 cells implicated a form of cis-dominant regulation, we hypothesize that a common mechanism generating homologous mutations in class I genes is operative in S49 tumor cells." @default.
- W2088697902 created "2016-06-24" @default.
- W2088697902 creator A5018915388 @default.
- W2088697902 creator A5028584310 @default.
- W2088697902 date "1989-08-01" @default.
- W2088697902 modified "2023-10-14" @default.
- W2088697902 title "Cis-acting elements determine the locus-specific shutoff of class I major histocompatibility genes in murine S49 lymphoma sublines." @default.
- W2088697902 cites W1497278722 @default.
- W2088697902 cites W1558401720 @default.
- W2088697902 cites W1562079541 @default.
- W2088697902 cites W1567897487 @default.
- W2088697902 cites W1619496764 @default.
- W2088697902 cites W1628607703 @default.
- W2088697902 cites W1984337138 @default.
- W2088697902 cites W2000734326 @default.
- W2088697902 cites W2003553392 @default.
- W2088697902 cites W2009228522 @default.
- W2088697902 cites W2010346569 @default.
- W2088697902 cites W2013444122 @default.
- W2088697902 cites W2020130523 @default.
- W2088697902 cites W2029793114 @default.
- W2088697902 cites W2031618552 @default.
- W2088697902 cites W2038354261 @default.
- W2088697902 cites W2044220392 @default.
- W2088697902 cites W2052918890 @default.
- W2088697902 cites W2057908124 @default.
- W2088697902 cites W2064813062 @default.
- W2088697902 cites W2074654331 @default.
- W2088697902 cites W2075507370 @default.
- W2088697902 cites W2080757497 @default.
- W2088697902 cites W2099398466 @default.
- W2088697902 cites W2111441225 @default.
- W2088697902 cites W2124404568 @default.
- W2088697902 cites W2172294843 @default.
- W2088697902 cites W2180597555 @default.
- W2088697902 cites W2412941035 @default.
- W2088697902 cites W49336188 @default.
- W2088697902 doi "https://doi.org/10.1073/pnas.86.16.6288" @default.
- W2088697902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/297823" @default.
- W2088697902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2762327" @default.
- W2088697902 hasPublicationYear "1989" @default.
- W2088697902 type Work @default.
- W2088697902 sameAs 2088697902 @default.
- W2088697902 citedByCount "12" @default.
- W2088697902 countsByYear W20886979022014 @default.
- W2088697902 countsByYear W20886979022020 @default.
- W2088697902 crossrefType "journal-article" @default.
- W2088697902 hasAuthorship W2088697902A5018915388 @default.
- W2088697902 hasAuthorship W2088697902A5028584310 @default.
- W2088697902 hasBestOaLocation W20886979021 @default.
- W2088697902 hasConcept C104317684 @default.
- W2088697902 hasConcept C127716648 @default.
- W2088697902 hasConcept C134305767 @default.
- W2088697902 hasConcept C150194340 @default.
- W2088697902 hasConcept C153911025 @default.
- W2088697902 hasConcept C207936829 @default.
- W2088697902 hasConcept C54355233 @default.
- W2088697902 hasConcept C84597430 @default.
- W2088697902 hasConcept C86803240 @default.
- W2088697902 hasConceptScore W2088697902C104317684 @default.
- W2088697902 hasConceptScore W2088697902C127716648 @default.
- W2088697902 hasConceptScore W2088697902C134305767 @default.
- W2088697902 hasConceptScore W2088697902C150194340 @default.
- W2088697902 hasConceptScore W2088697902C153911025 @default.
- W2088697902 hasConceptScore W2088697902C207936829 @default.
- W2088697902 hasConceptScore W2088697902C54355233 @default.
- W2088697902 hasConceptScore W2088697902C84597430 @default.
- W2088697902 hasConceptScore W2088697902C86803240 @default.
- W2088697902 hasIssue "16" @default.
- W2088697902 hasLocation W20886979021 @default.
- W2088697902 hasLocation W20886979022 @default.
- W2088697902 hasLocation W20886979023 @default.
- W2088697902 hasLocation W20886979024 @default.
- W2088697902 hasOpenAccess W2088697902 @default.
- W2088697902 hasPrimaryLocation W20886979021 @default.
- W2088697902 hasRelatedWork W1881137434 @default.
- W2088697902 hasRelatedWork W1992103432 @default.
- W2088697902 hasRelatedWork W2008960745 @default.
- W2088697902 hasRelatedWork W2060908277 @default.
- W2088697902 hasRelatedWork W2081894066 @default.
- W2088697902 hasRelatedWork W2367096107 @default.
- W2088697902 hasRelatedWork W2438531772 @default.
- W2088697902 hasRelatedWork W2898777353 @default.
- W2088697902 hasRelatedWork W4251027247 @default.
- W2088697902 hasRelatedWork W3021321537 @default.
- W2088697902 hasVolume "86" @default.
- W2088697902 isParatext "false" @default.
- W2088697902 isRetracted "false" @default.
- W2088697902 magId "2088697902" @default.
- W2088697902 workType "article" @default.