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• W2088704803 endingPage "3275" @default.
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• W2088704803 abstract "Abstract The yeast Rgt1 repressor is a bifunctional protein that acts as a transcriptional repressor and activator. Under glucose‐limited conditions, Rgt1 induces transcriptional repression by forming a repressive complex with its corepressors Mth1 and Std1. Here, we show that Rgt1 is converted from a transcriptional repressor into an activator under high glucose conditions and this occurs through two independent but consecutive events mediated by two glucose signaling pathways: (1) disruption of the repressive complex by the Rgt2/Snf3 pathway; (2) phosphorylation of Rgt1 by the cAMP‐dependent protein kinase (cAMP‐PKA) pathway. Rgt1 is phosphorylated by PKA at four serine residues within its amino‐terminal region, but this does not occur until the repressive complex is disrupted. While phosphorylation of any one of these sites is sufficient to enable Rgt1 to induce transcriptional activation, phosphorylation of all the sites results in the release of Rgt1 from DNA. We discuss how the bifunctional properties of Rgt1 are regulated through differential phosphorylation. J. Cell. Biochem. 112: 3268–3275, 2011. © 2011 Wiley Periodicals, Inc." @default.
• W2088704803 created "2016-06-24" @default.
• W2088704803 creator A5000388343 @default.
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• W2088704803 date "2011-10-15" @default.
• W2088704803 modified "2023-10-11" @default.
• W2088704803 title "Functional dissection of the glucose signaling pathways that regulate the yeast glucose transporter gene (HXT) repressor Rgt1" @default.
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• W2088704803 doi "https://doi.org/10.1002/jcb.23253" @default.
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• W2088704803 hasPublicationYear "2011" @default.
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