FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088705026> ?p ?o ?g. }

• W2088705026 abstract "Predictive or treatment selection biomarkers are usually evaluated in a subgroup or regression analysis with focus on the treatment-by-marker interaction. Under a potential outcome framework (Huang, Gilbert and Janes [Biometrics 68 (2012) 687-696]), a predictive biomarker is considered a predictor for a desirable treatment benefit (defined by comparing potential outcomes for different treatments) and evaluated using familiar concepts in prediction and classification. However, the desired treatment benefit is unobservable because each patient can receive only one treatment in a typical study. Huang et al. overcome this problem by assuming monotonicity of potential outcomes, with one treatment dominating the other in all patients. Motivated by an HIV example that appears to violate the monotonicity assumption, we propose a different approach based on covariates and random effects for evaluating predictive biomarkers under the potential outcome framework. Under the proposed approach, the parameters of interest can be identified by assuming conditional independence of potential outcomes given observed covariates, and a sensitivity analysis can be performed by incorporating an unobserved random effect that accounts for any residual dependence. Application of this approach to the motivating example shows that baseline viral load and CD4 cell count are both useful as predictive biomarkers for choosing antiretroviral drugs for treatment-naive patients." @default.
• W2088705026 created "2016-06-24" @default.
• W2088705026 creator A5002854695 @default.
• W2088705026 creator A5019005078 @default.
• W2088705026 creator A5021104158 @default.
• W2088705026 creator A5078901632 @default.
• W2088705026 date "2014-12-01" @default.
• W2088705026 modified "2023-10-16" @default.
• W2088705026 title "The use of covariates and random effects in evaluating predictive biomarkers under a potential outcome framework" @default.
• W2088705026 cites W1572302037 @default.
• W2088705026 cites W1978108654 @default.
• W2088705026 cites W1979361708 @default.
• W2088705026 cites W1984752755 @default.
• W2088705026 cites W1988985184 @default.
• W2088705026 cites W2003336670 @default.
• W2088705026 cites W2016765200 @default.
• W2088705026 cites W2035655846 @default.
• W2088705026 cites W2060899622 @default.
• W2088705026 cites W2066153095 @default.
• W2088705026 cites W2066648075 @default.
• W2088705026 cites W2070505631 @default.
• W2088705026 cites W2087140548 @default.
• W2088705026 cites W2088705026 @default.
• W2088705026 cites W2098184866 @default.
• W2088705026 cites W2105882193 @default.
• W2088705026 cites W2115749781 @default.
• W2088705026 cites W2142538462 @default.
• W2088705026 cites W2155311724 @default.
• W2088705026 cites W3106017199 @default.
• W2088705026 cites W4232875550 @default.
• W2088705026 doi "https://doi.org/10.1214/14-aoas773" @default.
• W2088705026 hasPublicationYear "2014" @default.
• W2088705026 type Work @default.
• W2088705026 sameAs 2088705026 @default.
• W2088705026 citedByCount "15" @default.
• W2088705026 countsByYear W20887050262014 @default.
• W2088705026 countsByYear W20887050262015 @default.
• W2088705026 countsByYear W20887050262016 @default.
• W2088705026 countsByYear W20887050262017 @default.
• W2088705026 countsByYear W20887050262019 @default.
• W2088705026 countsByYear W20887050262020 @default.
• W2088705026 countsByYear W20887050262021 @default.
• W2088705026 countsByYear W20887050262023 @default.
• W2088705026 crossrefType "journal-article" @default.
• W2088705026 hasAuthorship W2088705026A5002854695 @default.
• W2088705026 hasAuthorship W2088705026A5019005078 @default.
• W2088705026 hasAuthorship W2088705026A5021104158 @default.
• W2088705026 hasAuthorship W2088705026A5078901632 @default.
• W2088705026 hasBestOaLocation W20887050261 @default.
• W2088705026 hasConcept C105795698 @default.
• W2088705026 hasConcept C119043178 @default.
• W2088705026 hasConcept C119857082 @default.
• W2088705026 hasConcept C126322002 @default.
• W2088705026 hasConcept C144237770 @default.
• W2088705026 hasConcept C148220186 @default.
• W2088705026 hasConcept C149782125 @default.
• W2088705026 hasConcept C154945302 @default.
• W2088705026 hasConcept C168743327 @default.
• W2088705026 hasConcept C2780695315 @default.
• W2088705026 hasConcept C33923547 @default.
• W2088705026 hasConcept C41008148 @default.
• W2088705026 hasConcept C71924100 @default.
• W2088705026 hasConcept C79772020 @default.
• W2088705026 hasConcept C95190672 @default.
• W2088705026 hasConceptScore W2088705026C105795698 @default.
• W2088705026 hasConceptScore W2088705026C119043178 @default.
• W2088705026 hasConceptScore W2088705026C119857082 @default.
• W2088705026 hasConceptScore W2088705026C126322002 @default.
• W2088705026 hasConceptScore W2088705026C144237770 @default.
• W2088705026 hasConceptScore W2088705026C148220186 @default.
• W2088705026 hasConceptScore W2088705026C149782125 @default.
• W2088705026 hasConceptScore W2088705026C154945302 @default.
• W2088705026 hasConceptScore W2088705026C168743327 @default.
• W2088705026 hasConceptScore W2088705026C2780695315 @default.
• W2088705026 hasConceptScore W2088705026C33923547 @default.
• W2088705026 hasConceptScore W2088705026C41008148 @default.
• W2088705026 hasConceptScore W2088705026C71924100 @default.
• W2088705026 hasConceptScore W2088705026C79772020 @default.
• W2088705026 hasConceptScore W2088705026C95190672 @default.
• W2088705026 hasIssue "4" @default.
• W2088705026 hasLocation W20887050261 @default.
• W2088705026 hasLocation W20887050262 @default.
• W2088705026 hasLocation W20887050263 @default.
• W2088705026 hasLocation W20887050264 @default.
• W2088705026 hasLocation W20887050265 @default.
• W2088705026 hasLocation W20887050266 @default.
• W2088705026 hasOpenAccess W2088705026 @default.
• W2088705026 hasPrimaryLocation W20887050261 @default.
• W2088705026 hasRelatedWork W1993808353 @default.
• W2088705026 hasRelatedWork W2088705026 @default.
• W2088705026 hasRelatedWork W2131950279 @default.
• W2088705026 hasRelatedWork W2278527105 @default.
• W2088705026 hasRelatedWork W2597825193 @default.
• W2088705026 hasRelatedWork W2885634977 @default.
• W2088705026 hasRelatedWork W2998582472 @default.
• W2088705026 hasRelatedWork W3162703145 @default.
• W2088705026 hasRelatedWork W4240194353 @default.
• W2088705026 hasRelatedWork W4292182933 @default.
• W2088705026 hasVolume "8" @default.
• W2088705026 isParatext "false" @default.

• next