FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088705118> ?p ?o ?g. }

• W2088705118 endingPage "652" @default.
• W2088705118 startingPage "647" @default.
• W2088705118 abstract "Transgenic mice carrying human A30P mutated α-synuclein demonstrate hypolocomotion and dysfunction of the presynaptic machinery of dopamine overflow, induced by reducing capacity of the dopamine storage pool. We suggested that overexpression of α-synuclein may change sensitivity of these mice to L-DOPA. Current study assessed behavioural and neurochemical responses in A30P mice to L-DOPA using automated activity monitoring and voltammetry. We confirmed decreased locomotion and rearing of A30P transgenic mice compared to wild-type controls. L-DOPA (10–200 mg/kg, i.p.) dose-dependently lowered locomotor activity, including stereotypy, in both genotypes, but the effects were larger in A30P mice. The effects of drug on stimulated dopamine overflow were investigated in the nucleus accumbens shell. L-DOPA at the dose of 30 mg/kg did not change peak dopamine overflow induced by 10 Hz stimulation of the medial forebrain bundle in either genotype, but increased it at the higher (20–50 Hz) frequencies of stimulation. At the higher frequencies of stimulation, L-DOPA elevated dopamine overflow significantly more in A30P mice than in the control animals. These data show that A30P transgenic mice are more sensitive to the effects of L-DOPA at both behavioural and neurochemical level." @default.
• W2088705118 created "2016-06-24" @default.
• W2088705118 creator A5005270668 @default.
• W2088705118 creator A5010575514 @default.
• W2088705118 creator A5027324596 @default.
• W2088705118 date "2009-03-01" @default.
• W2088705118 modified "2023-10-07" @default.
• W2088705118 title "Behavioural and neurochemical response of α-synuclein A30P transgenic mice to the effects of L-DOPA" @default.
• W2088705118 cites W1571781207 @default.
• W2088705118 cites W1967905541 @default.
• W2088705118 cites W2004137994 @default.
• W2088705118 cites W2012225839 @default.
• W2088705118 cites W2027639125 @default.
• W2088705118 cites W2035659720 @default.
• W2088705118 cites W2039279856 @default.
• W2088705118 cites W2040706104 @default.
• W2088705118 cites W2047465729 @default.
• W2088705118 cites W2056990056 @default.
• W2088705118 cites W2076114665 @default.
• W2088705118 cites W2080949995 @default.
• W2088705118 cites W2091265794 @default.
• W2088705118 cites W2104061091 @default.
• W2088705118 cites W2108697350 @default.
• W2088705118 cites W2130909417 @default.
• W2088705118 cites W2141204033 @default.
• W2088705118 cites W2154761807 @default.
• W2088705118 cites W2157844171 @default.
• W2088705118 cites W2170124256 @default.
• W2088705118 cites W2171281715 @default.
• W2088705118 cites W4255597145 @default.
• W2088705118 cites W4319425454 @default.
• W2088705118 doi "https://doi.org/10.1016/j.neuropharm.2008.11.004" @default.
• W2088705118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19084027" @default.
• W2088705118 hasPublicationYear "2009" @default.
• W2088705118 type Work @default.
• W2088705118 sameAs 2088705118 @default.
• W2088705118 citedByCount "21" @default.
• W2088705118 countsByYear W20887051182012 @default.
• W2088705118 countsByYear W20887051182013 @default.
• W2088705118 countsByYear W20887051182014 @default.
• W2088705118 countsByYear W20887051182019 @default.
• W2088705118 countsByYear W20887051182023 @default.
• W2088705118 crossrefType "journal-article" @default.
• W2088705118 hasAuthorship W2088705118A5005270668 @default.
• W2088705118 hasAuthorship W2088705118A5010575514 @default.
• W2088705118 hasAuthorship W2088705118A5027324596 @default.
• W2088705118 hasConcept C102230213 @default.
• W2088705118 hasConcept C104317684 @default.
• W2088705118 hasConcept C126322002 @default.
• W2088705118 hasConcept C134018914 @default.
• W2088705118 hasConcept C141035611 @default.
• W2088705118 hasConcept C169760540 @default.
• W2088705118 hasConcept C185592680 @default.
• W2088705118 hasConcept C24998067 @default.
• W2088705118 hasConcept C25876315 @default.
• W2088705118 hasConcept C2776552330 @default.
• W2088705118 hasConcept C2776669363 @default.
• W2088705118 hasConcept C2777193897 @default.
• W2088705118 hasConcept C2779459141 @default.
• W2088705118 hasConcept C2780062018 @default.
• W2088705118 hasConcept C513476851 @default.
• W2088705118 hasConcept C55493867 @default.
• W2088705118 hasConcept C71924100 @default.
• W2088705118 hasConcept C86803240 @default.
• W2088705118 hasConceptScore W2088705118C102230213 @default.
• W2088705118 hasConceptScore W2088705118C104317684 @default.
• W2088705118 hasConceptScore W2088705118C126322002 @default.
• W2088705118 hasConceptScore W2088705118C134018914 @default.
• W2088705118 hasConceptScore W2088705118C141035611 @default.
• W2088705118 hasConceptScore W2088705118C169760540 @default.
• W2088705118 hasConceptScore W2088705118C185592680 @default.
• W2088705118 hasConceptScore W2088705118C24998067 @default.
• W2088705118 hasConceptScore W2088705118C25876315 @default.
• W2088705118 hasConceptScore W2088705118C2776552330 @default.
• W2088705118 hasConceptScore W2088705118C2776669363 @default.
• W2088705118 hasConceptScore W2088705118C2777193897 @default.
• W2088705118 hasConceptScore W2088705118C2779459141 @default.
• W2088705118 hasConceptScore W2088705118C2780062018 @default.
• W2088705118 hasConceptScore W2088705118C513476851 @default.
• W2088705118 hasConceptScore W2088705118C55493867 @default.
• W2088705118 hasConceptScore W2088705118C71924100 @default.
• W2088705118 hasConceptScore W2088705118C86803240 @default.
• W2088705118 hasIssue "3" @default.
• W2088705118 hasLocation W20887051181 @default.
• W2088705118 hasLocation W20887051182 @default.
• W2088705118 hasOpenAccess W2088705118 @default.
• W2088705118 hasPrimaryLocation W20887051181 @default.
• W2088705118 hasRelatedWork W1833633755 @default.
• W2088705118 hasRelatedWork W1974678968 @default.
• W2088705118 hasRelatedWork W2019984182 @default.
• W2088705118 hasRelatedWork W2027086358 @default.
• W2088705118 hasRelatedWork W2044892899 @default.
• W2088705118 hasRelatedWork W2047315251 @default.
• W2088705118 hasRelatedWork W2049093197 @default.
• W2088705118 hasRelatedWork W2058176316 @default.
• W2088705118 hasRelatedWork W2224006131 @default.
• W2088705118 hasRelatedWork W2378442583 @default.
• W2088705118 hasVolume "56" @default.

• next