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- W2088744089 abstract "To measure the capacity of the upper small intestine to dispose of acid in the absence of bile and pancreatic juice, in vivo titrations were performed in cat upper duodenum, lower duodenum, and jejunum to various pH levels in a recirculating perfusion circuit in groups of five cats. The effect of secretin in this capacity to dispose of acid was investigated by repeating the experiment with intravenous infusion of GIH secretin at 3 CU/kg/hr. Identical results were obtained in the lower duodenum and jejunum, but significant increase in rate of H+ removal was seen in the upper duodenum at all pH levels. Histological examination showed that the Brunner's glands did not extend for more than half of the length of upper duodenum, and are not found in either the lower duodenum or jejunum. No morphological changes were detectable other than depletion of mucin in Brunner's glands in animals stimulated with secretin. It is concluded that the only effect secretin has on H+ transport in the upper small intestine is to increase alkaline secretion from, for example, Brunner's glands, resulting in a larger amount of neutralization." @default.
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- W2088744089 date "1976-05-01" @default.
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- W2088744089 title "The effect of secretion on hydrogen ion transport in the duodenum and jejunum" @default.
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- W2088744089 doi "https://doi.org/10.1016/0022-4804(76)90121-9" @default.
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