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- W2088744527 endingPage "2604" @default.
- W2088744527 startingPage "2577" @default.
- W2088744527 abstract "Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in the cellular cytoplasm, and is ultimately destined for transport into mitochondria as a master fuel input undergirding citric acid cycle carbon flux. In mitochondria, pyruvate drives ATP production by oxidative phosphorylation and multiple biosynthetic pathways intersecting the citric acid cycle. Mitochondrial pyruvate metabolism is regulated by many enzymes, including the recently discovered mitochondria pyruvate carrier, pyruvate dehydrogenase, and pyruvate carboxylase, to modulate overall pyruvate carbon flux. Mutations in any of the genes encoding for proteins regulating pyruvate metabolism may lead to disease. Numerous cases have been described. Aberrant pyruvate metabolism plays an especially prominent role in cancer, heart failure, and neurodegeneration. Because most major diseases involve aberrant metabolism, understanding and exploiting pyruvate carbon flux may yield novel treatments that enhance human health." @default.
- W2088744527 created "2016-06-24" @default.
- W2088744527 creator A5058481769 @default.
- W2088744527 creator A5060173376 @default.
- W2088744527 creator A5087925749 @default.
- W2088744527 date "2013-12-21" @default.
- W2088744527 modified "2023-10-11" @default.
- W2088744527 title "Regulation of pyruvate metabolism and human disease" @default.
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