Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088753619> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2088753619 abstract "Neoadjuvant chemotherapy is the treatment of choice for locally-advanced breast cancer and leads to down staging and improved breast-conserving therapy (BCT) rates. While its efficacy is well established, considerably less is known about the most effective regimen. We have performed a retrospective analysis of 132 breast cancer patients who had undergone neoadjuvant chemotherapy at our institution. Patients had either received a) anthracyclines (A, n=35), b) anthracyclines and taxanes (AT, n=55), or c) neither of the two compounds (NoA/T, n=42). Clinical response, pathological response and survival were evaluated in each arm. While all three regimens resulted in significant tumor regression, AT was most effective with a mean tumor shrinkage of 39% (ultrasound) and 41% (mammography) (Kruskal-Wallis, p=0.004, and p=0.027). Breast conservation was achieved in 75% by AT, in 49% by A, and in 19% by NoA/T (Kruskal-Wallis, p<0.001). The treatment groups did not differ in respect to pathological complete response (pCR) (chi2-test, p=0.068), although higher cumulative anthracycline doses were predictive of pCR in multivariate analyses (p=0.022). While the mammographic but not the ultrasound-determined tumor diameter determined whether a woman underwent BCT, only an ultrasound-determined size reduction was predictive for disease-free survival (DFS) and overall survival (OS) (log rank, p=0.0093, and p=0.044, respectively). Other parameters that affected BCT rates were age (p= 0.003), year of diagnosis (p=<0.001), presence of multifocal disease (p= 0.032) and the cumulative anthracycline dose (p= <0.001). While the combination of anthracyclines and taxanes is most effective in achieving clinical remission and BCT, the cumulative anthracycline dose appears most important for achieving pCR." @default.
- W2088753619 created "2016-06-24" @default.
- W2088753619 creator A5015052494 @default.
- W2088753619 creator A5019321075 @default.
- W2088753619 creator A5025310604 @default.
- W2088753619 creator A5025692478 @default.
- W2088753619 creator A5036714134 @default.
- W2088753619 creator A5052800865 @default.
- W2088753619 creator A5056269110 @default.
- W2088753619 creator A5091446672 @default.
- W2088753619 date "2007-12-01" @default.
- W2088753619 modified "2023-09-26" @default.
- W2088753619 title "Efficacy of Primary Systemic Chemotherapy Regimen Containing Anthracyclines with/without Taxanes in Comparison to CMF in Women with Early Breast Cancer" @default.
- W2088753619 cites W1955397179 @default.
- W2088753619 cites W2012800796 @default.
- W2088753619 cites W2041342949 @default.
- W2088753619 cites W2046320256 @default.
- W2088753619 cites W206480088 @default.
- W2088753619 cites W2075557130 @default.
- W2088753619 cites W2086766680 @default.
- W2088753619 cites W2125729597 @default.
- W2088753619 cites W2135800076 @default.
- W2088753619 cites W2140654333 @default.
- W2088753619 cites W2164774797 @default.
- W2088753619 cites W2171958606 @default.
- W2088753619 cites W2262955759 @default.
- W2088753619 doi "https://doi.org/10.1179/joc.2007.19.6.731" @default.
- W2088753619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18230558" @default.
- W2088753619 hasPublicationYear "2007" @default.
- W2088753619 type Work @default.
- W2088753619 sameAs 2088753619 @default.
- W2088753619 citedByCount "0" @default.
- W2088753619 crossrefType "journal-article" @default.
- W2088753619 hasAuthorship W2088753619A5015052494 @default.
- W2088753619 hasAuthorship W2088753619A5019321075 @default.
- W2088753619 hasAuthorship W2088753619A5025310604 @default.
- W2088753619 hasAuthorship W2088753619A5025692478 @default.
- W2088753619 hasAuthorship W2088753619A5036714134 @default.
- W2088753619 hasAuthorship W2088753619A5052800865 @default.
- W2088753619 hasAuthorship W2088753619A5056269110 @default.
- W2088753619 hasAuthorship W2088753619A5091446672 @default.
- W2088753619 hasConcept C121608353 @default.
- W2088753619 hasConcept C126322002 @default.
- W2088753619 hasConcept C143998085 @default.
- W2088753619 hasConcept C2776694085 @default.
- W2088753619 hasConcept C2776802502 @default.
- W2088753619 hasConcept C2778336483 @default.
- W2088753619 hasConcept C2781413609 @default.
- W2088753619 hasConcept C29456083 @default.
- W2088753619 hasConcept C530470458 @default.
- W2088753619 hasConcept C71924100 @default.
- W2088753619 hasConceptScore W2088753619C121608353 @default.
- W2088753619 hasConceptScore W2088753619C126322002 @default.
- W2088753619 hasConceptScore W2088753619C143998085 @default.
- W2088753619 hasConceptScore W2088753619C2776694085 @default.
- W2088753619 hasConceptScore W2088753619C2776802502 @default.
- W2088753619 hasConceptScore W2088753619C2778336483 @default.
- W2088753619 hasConceptScore W2088753619C2781413609 @default.
- W2088753619 hasConceptScore W2088753619C29456083 @default.
- W2088753619 hasConceptScore W2088753619C530470458 @default.
- W2088753619 hasConceptScore W2088753619C71924100 @default.
- W2088753619 hasLocation W20887536191 @default.
- W2088753619 hasLocation W20887536192 @default.
- W2088753619 hasOpenAccess W2088753619 @default.
- W2088753619 hasPrimaryLocation W20887536191 @default.
- W2088753619 hasRelatedWork W1563147852 @default.
- W2088753619 hasRelatedWork W1974504826 @default.
- W2088753619 hasRelatedWork W2033108326 @default.
- W2088753619 hasRelatedWork W2254249499 @default.
- W2088753619 hasRelatedWork W2370098356 @default.
- W2088753619 hasRelatedWork W2390968636 @default.
- W2088753619 hasRelatedWork W2594303266 @default.
- W2088753619 hasRelatedWork W2980453143 @default.
- W2088753619 hasRelatedWork W3030794620 @default.
- W2088753619 hasRelatedWork W757206253 @default.
- W2088753619 isParatext "false" @default.
- W2088753619 isRetracted "false" @default.
- W2088753619 magId "2088753619" @default.
- W2088753619 workType "article" @default.