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- W2088756566 endingPage "11" @default.
- W2088756566 startingPage "1" @default.
- W2088756566 abstract "Bromodomain-containing protein 4 (Brd4) and hexamethylene bisacetamide (HMBA) inducible protein 1 (HEXIM1) are two opposing regulators of the positive transcription elongation factor b (P-TEFb), which is the master modulator of RNA polymerase II during transcriptional elongation. While Brd4 recruits P-TEFb to promoter-proximal chromatins to activate transcription, HEXIM1 sequesters P-TEFb into an inactive complex containing the 7SK small nuclear RNA. Besides regulating P-TEFb’s transcriptional activity, recent evidence demonstrates that both Brd4 and HEXIM1 also play novel roles in cell cycle progression and tumorigenesis. Here we will discuss the current knowledge on Brd4 and HEXIM1 and their implication as novel therapeutic options against cancer." @default.
- W2088756566 created "2016-06-24" @default.
- W2088756566 creator A5022982724 @default.
- W2088756566 creator A5026522632 @default.
- W2088756566 creator A5032448354 @default.
- W2088756566 creator A5070945830 @default.
- W2088756566 date "2014-01-01" @default.
- W2088756566 modified "2023-10-17" @default.
- W2088756566 title "Brd4 and HEXIM1: Multiple Roles in P-TEFb Regulation and Cancer" @default.
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