Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088765481> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2088765481 abstract "Abstract Objective To investigate the activity of anti-malarial dihydroartemisinin (DHA) on tumor growth, lymphangiogenesis, nodal and lung metastasis and survival in mice bearing Lewis lung carcimoma (LLC). Methods The models of C57BL/6 mice transplantation tumors were established via subcutaneous injection of LLC cells and divided into 4 groups; control group, DHA group, DHA + ferrous sulfate (FS) group and FS group, with 25 mice in each group. Tumor volumes and weights, nodal and lung metastasis, and survival were monitored. Tumor lymphatic microvessel density (LMVD) was determined by lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) immnohistochemistry. After LLC cells were treated with DHA or DHA + FS, protein and mRNA levels of vascular endothelial growth factor (VEGF) -C were evaluated by Western blotting and real time quantitative RT-PCR, respectively. Results Oral administration of DHA or DHA + FS inhibited lymph node and lung metastasis, and prolonged survival. However, no significant tumor growth retardation effect was observed when mice were treated with DHA alone. The inhibited tumor metastasis was related to the decreased LMVD in the peritumoral regions, but not in the in-tratumoral regions. DHA significantly down-regulated the expression of VEGF-C protein and mRNA in LLC cells. Conclusion DHA effectively inhibits LLC transplantation tumor lymphangiogenesis, nodal and lung metastasis, and may be a promising chemotherapeutic agent for controlling lung cancer metastasis by decreasing VEGF-C expression." @default.
- W2088765481 created "2016-06-24" @default.
- W2088765481 creator A5031173584 @default.
- W2088765481 creator A5042241049 @default.
- W2088765481 creator A5044691967 @default.
- W2088765481 creator A5045422255 @default.
- W2088765481 creator A5061294959 @default.
- W2088765481 date "2007-10-01" @default.
- W2088765481 modified "2023-09-26" @default.
- W2088765481 title "Inhibition of lymphangiogenesis, nodal and lung metastasis by dihy-droartemisinin in mice bearing Lewis lung carcinoma" @default.
- W2088765481 cites W1970913595 @default.
- W2088765481 cites W1985804036 @default.
- W2088765481 cites W1992101966 @default.
- W2088765481 cites W1995521183 @default.
- W2088765481 cites W2001517548 @default.
- W2088765481 cites W2011587428 @default.
- W2088765481 cites W2018053695 @default.
- W2088765481 cites W2019647403 @default.
- W2088765481 cites W2049708133 @default.
- W2088765481 cites W2052435822 @default.
- W2088765481 cites W2054618296 @default.
- W2088765481 cites W2065654855 @default.
- W2088765481 cites W2085568473 @default.
- W2088765481 cites W2102212301 @default.
- W2088765481 cites W2112526465 @default.
- W2088765481 cites W2113215822 @default.
- W2088765481 cites W2131661896 @default.
- W2088765481 cites W2135201226 @default.
- W2088765481 cites W2150330391 @default.
- W2088765481 cites W2156262303 @default.
- W2088765481 cites W2162079763 @default.
- W2088765481 cites W2184709802 @default.
- W2088765481 doi "https://doi.org/10.1016/s1000-1948(07)60056-2" @default.
- W2088765481 hasPublicationYear "2007" @default.
- W2088765481 type Work @default.
- W2088765481 sameAs 2088765481 @default.
- W2088765481 citedByCount "0" @default.
- W2088765481 crossrefType "journal-article" @default.
- W2088765481 hasAuthorship W2088765481A5031173584 @default.
- W2088765481 hasAuthorship W2088765481A5042241049 @default.
- W2088765481 hasAuthorship W2088765481A5044691967 @default.
- W2088765481 hasAuthorship W2088765481A5045422255 @default.
- W2088765481 hasAuthorship W2088765481A5061294959 @default.
- W2088765481 hasConcept C103041312 @default.
- W2088765481 hasConcept C121608353 @default.
- W2088765481 hasConcept C126322002 @default.
- W2088765481 hasConcept C142724271 @default.
- W2088765481 hasConcept C146285616 @default.
- W2088765481 hasConcept C167734588 @default.
- W2088765481 hasConcept C181152851 @default.
- W2088765481 hasConcept C2776256026 @default.
- W2088765481 hasConcept C2776636583 @default.
- W2088765481 hasConcept C2777025900 @default.
- W2088765481 hasConcept C2777714996 @default.
- W2088765481 hasConcept C2777847059 @default.
- W2088765481 hasConcept C2779013556 @default.
- W2088765481 hasConcept C2911091166 @default.
- W2088765481 hasConcept C502942594 @default.
- W2088765481 hasConcept C71924100 @default.
- W2088765481 hasConceptScore W2088765481C103041312 @default.
- W2088765481 hasConceptScore W2088765481C121608353 @default.
- W2088765481 hasConceptScore W2088765481C126322002 @default.
- W2088765481 hasConceptScore W2088765481C142724271 @default.
- W2088765481 hasConceptScore W2088765481C146285616 @default.
- W2088765481 hasConceptScore W2088765481C167734588 @default.
- W2088765481 hasConceptScore W2088765481C181152851 @default.
- W2088765481 hasConceptScore W2088765481C2776256026 @default.
- W2088765481 hasConceptScore W2088765481C2776636583 @default.
- W2088765481 hasConceptScore W2088765481C2777025900 @default.
- W2088765481 hasConceptScore W2088765481C2777714996 @default.
- W2088765481 hasConceptScore W2088765481C2777847059 @default.
- W2088765481 hasConceptScore W2088765481C2779013556 @default.
- W2088765481 hasConceptScore W2088765481C2911091166 @default.
- W2088765481 hasConceptScore W2088765481C502942594 @default.
- W2088765481 hasConceptScore W2088765481C71924100 @default.
- W2088765481 hasLocation W20887654811 @default.
- W2088765481 hasOpenAccess W2088765481 @default.
- W2088765481 hasPrimaryLocation W20887654811 @default.
- W2088765481 hasRelatedWork W2045877213 @default.
- W2088765481 hasRelatedWork W212824164 @default.
- W2088765481 hasRelatedWork W2352208538 @default.
- W2088765481 hasRelatedWork W2393686989 @default.
- W2088765481 hasRelatedWork W2413203121 @default.
- W2088765481 hasRelatedWork W2427262399 @default.
- W2088765481 hasRelatedWork W3032597358 @default.
- W2088765481 hasRelatedWork W30855403 @default.
- W2088765481 hasRelatedWork W3198647362 @default.
- W2088765481 hasRelatedWork W3029953409 @default.
- W2088765481 isParatext "false" @default.
- W2088765481 isRetracted "false" @default.
- W2088765481 magId "2088765481" @default.
- W2088765481 workType "article" @default.