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- W2088765494 abstract "Effects of polymyxin B on the synthesis and degradation of lipid, ribonucleic acid (RNA) and protein in Pseudomonas aeruginosa were investigated. It was found that polymyxin B caused a marked degradation of the lipid fraction which was prelabeled with (3H-2)-glycerol. Thin-layer chromatographic analysis indicated that the main degraded lipids were phosphatidylethanolamine and phosphatidylglycerol, which constituted 80% and 15% of the total phospholipids of this organism, respectively. Polymyxin B also inhibited synthesis of RNA and protein in vivo. The severe inhibition of the uptake of labeled amino acids by polymyxin B indicated that the observed inhibition of RNA and protein synthesis possibly occurred at the level of substrate transports. The degradation of phospholipid might account for the defective membrane activities." @default.
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- W2088765494 date "1975-01-01" @default.
- W2088765494 modified "2023-09-24" @default.
- W2088765494 title "Degradation of phospholipid in Pseudomonas aeruginosa induced by polymyxin B." @default.
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- W2088765494 doi "https://doi.org/10.7164/antibiotics.28.689" @default.
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