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• W2088782150 abstract "Long-term synaptic plasticity is believed to underlie the capacity for learning and memory. In the cerebellum, for example, long-term plasticity contributes to eyelid conditioning and to learning in eye movement systems. We report evidence for a decrementing form of cerebellar plasticity as revealed by the behavioral properties of eyelid conditioning in the rabbit. We find that conditioned eyelid responses exhibit within-session changes that recover by the next day. These changes, which increase with the interstimulus interval, involve decreases in conditioned response magnitude and likelihood as well as increases in latency to onset. Within-subject comparisons show that these changes differ in magnitude depending on the type of training, arguing against motor fatigue or changes in motor pathways downstream of the cerebellum. These phenomena are also observed when stimulation of mossy fibers substitutes for the conditioned stimulus, suggesting that changes take place within the cerebellum or in downstream efferent pathways. Together, these observations suggest a plasticity mechanism in the cerebellum that is induced during training sessions and fades within 23 h. To formalize this hypothesis more specifically, we show that incorporating a short-lasting potentiation at the granule cell to Purkinje cell synapses in a computer simulation of the cerebellum reproduces these behavioral effects. We propose the working hypothesis that the presynaptic form of long-term potentiation observed at these synapses is reversed by time rather than by a corresponding long-term depression. These results demonstrate the utility of eyelid conditioning as a means to identify and characterize the rules that govern input to output transformations in the cerebellum." @default.
• W2088782150 created "2016-06-24" @default.
• W2088782150 creator A5006854970 @default.
• W2088782150 creator A5050051352 @default.
• W2088782150 creator A5063373498 @default.
• W2088782150 creator A5066212794 @default.
• W2088782150 date "2010-12-15" @default.
• W2088782150 modified "2023-10-10" @default.
• W2088782150 title "A Decrementing Form of Plasticity Apparent in Cerebellar Learning" @default.
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• W2088782150 doi "https://doi.org/10.1523/jneurosci.2455-10.2010" @default.
• W2088782150 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3014316" @default.
• W2088782150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21159969" @default.
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