Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088783585> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2088783585 endingPage "12951" @default.
- W2088783585 startingPage "12943" @default.
- W2088783585 abstract "We previously isolated a variant of the human U6 small nuclear RNA gene (87U6) and demonstrated that transcription of this gene is controlled by a novel internal promoter. It has now been shown that two blocks of sequence within the coding region are both necessary and sufficient to direct expression of 87U6 in transcription assays performed in vitro. In addition, 87U6 is expressed in vivo and can assemble into snRNP complexes. Specific primer extension assays on total RNA from HeLa cells shows that 87U6 RNA is present in these cells. Also, microinjection of plasmid encoded 87U6 genes into Xenopus laevis oocyte nuclei results in the expression of this variant RNA. Immunoprecipitation with anti-Sm antibodies suggests that 87U6 RNA assembles into a snRNP particle with U4 snRNA. Finally, the variant snRNA is capped with the U6 specific γ-monomethyl phosphate cap when incubated in HeLa extracts. These data suggest that 87U6 RNA may function in the splicing process, in a manner similar to the wild-type U6 RNA. The recent observations of a minor class of mRNA introns that are spliced by a distinct collection of snRNP particles suggest an important role for variant snRNAs in the splicing of transcripts with alternative splice junctions." @default.
- W2088783585 created "2016-06-24" @default.
- W2088783585 creator A5033652043 @default.
- W2088783585 creator A5038929700 @default.
- W2088783585 creator A5071606304 @default.
- W2088783585 creator A5071932590 @default.
- W2088783585 creator A5080500061 @default.
- W2088783585 date "1998-08-28" @default.
- W2088783585 modified "2023-09-27" @default.
- W2088783585 title "In Vivo Expression of a Variant Human U6 RNA from a Unique, Internal Promoter" @default.
- W2088783585 cites W1594912227 @default.
- W2088783585 cites W1644920038 @default.
- W2088783585 cites W185865329 @default.
- W2088783585 cites W1956253591 @default.
- W2088783585 cites W2134201576 @default.
- W2088783585 cites W2136163118 @default.
- W2088783585 cites W2142654067 @default.
- W2088783585 cites W2303818741 @default.
- W2088783585 cites W2345350759 @default.
- W2088783585 cites W4237655687 @default.
- W2088783585 doi "https://doi.org/10.1021/bi9811361" @default.
- W2088783585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9737874" @default.
- W2088783585 hasPublicationYear "1998" @default.
- W2088783585 type Work @default.
- W2088783585 sameAs 2088783585 @default.
- W2088783585 citedByCount "7" @default.
- W2088783585 countsByYear W20887835852018 @default.
- W2088783585 countsByYear W20887835852023 @default.
- W2088783585 crossrefType "journal-article" @default.
- W2088783585 hasAuthorship W2088783585A5033652043 @default.
- W2088783585 hasAuthorship W2088783585A5038929700 @default.
- W2088783585 hasAuthorship W2088783585A5071606304 @default.
- W2088783585 hasAuthorship W2088783585A5071932590 @default.
- W2088783585 hasAuthorship W2088783585A5080500061 @default.
- W2088783585 hasConcept C100299639 @default.
- W2088783585 hasConcept C104317684 @default.
- W2088783585 hasConcept C138885662 @default.
- W2088783585 hasConcept C153911025 @default.
- W2088783585 hasConcept C179926584 @default.
- W2088783585 hasConcept C194993378 @default.
- W2088783585 hasConcept C40000846 @default.
- W2088783585 hasConcept C41895202 @default.
- W2088783585 hasConcept C54355233 @default.
- W2088783585 hasConcept C54458228 @default.
- W2088783585 hasConcept C67705224 @default.
- W2088783585 hasConcept C68483431 @default.
- W2088783585 hasConcept C86803240 @default.
- W2088783585 hasConcept C94671646 @default.
- W2088783585 hasConcept C95444343 @default.
- W2088783585 hasConceptScore W2088783585C100299639 @default.
- W2088783585 hasConceptScore W2088783585C104317684 @default.
- W2088783585 hasConceptScore W2088783585C138885662 @default.
- W2088783585 hasConceptScore W2088783585C153911025 @default.
- W2088783585 hasConceptScore W2088783585C179926584 @default.
- W2088783585 hasConceptScore W2088783585C194993378 @default.
- W2088783585 hasConceptScore W2088783585C40000846 @default.
- W2088783585 hasConceptScore W2088783585C41895202 @default.
- W2088783585 hasConceptScore W2088783585C54355233 @default.
- W2088783585 hasConceptScore W2088783585C54458228 @default.
- W2088783585 hasConceptScore W2088783585C67705224 @default.
- W2088783585 hasConceptScore W2088783585C68483431 @default.
- W2088783585 hasConceptScore W2088783585C86803240 @default.
- W2088783585 hasConceptScore W2088783585C94671646 @default.
- W2088783585 hasConceptScore W2088783585C95444343 @default.
- W2088783585 hasIssue "37" @default.
- W2088783585 hasLocation W20887835851 @default.
- W2088783585 hasLocation W20887835852 @default.
- W2088783585 hasOpenAccess W2088783585 @default.
- W2088783585 hasPrimaryLocation W20887835851 @default.
- W2088783585 hasRelatedWork W1988271866 @default.
- W2088783585 hasRelatedWork W2042884888 @default.
- W2088783585 hasRelatedWork W2055138542 @default.
- W2088783585 hasRelatedWork W2113243883 @default.
- W2088783585 hasRelatedWork W2125959590 @default.
- W2088783585 hasRelatedWork W2128371536 @default.
- W2088783585 hasRelatedWork W2266792252 @default.
- W2088783585 hasRelatedWork W2317670334 @default.
- W2088783585 hasRelatedWork W2790140187 @default.
- W2088783585 hasRelatedWork W2992033677 @default.
- W2088783585 hasVolume "37" @default.
- W2088783585 isParatext "false" @default.
- W2088783585 isRetracted "false" @default.
- W2088783585 magId "2088783585" @default.
- W2088783585 workType "article" @default.