FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088797435> ?p ?o ?g. }

• W2088797435 endingPage "1346" @default.
• W2088797435 startingPage "1343" @default.
• W2088797435 abstract "Gene therapy using recombinant adeno-associated virus vectors (rAAV) is generally considered safe. During the course of a study designed to determine the long-term efficacy of rAAV-mediated gene therapy initiated in newborn mice with the lysosomal storage disease, mucopolysaccharidosis type VII (MPSVII), a significant incidence of hepatocellular carcinomas and angiosarcomas was discovered. A hepatocellular carcinoma was first detected in a 35-week-old mouse and by 72 weeks of age, three out of five rAAV-treated MPSVII mice had similar lesions. These types of tumors had not been seen previously in long-term studies of MPSVII mice using recombinant enzyme or bone marrow transplantation. In an attempt to ascertain whether mouse strain or GUSB expression confers susceptibility to tumor formation, we histopathologically examined untreated normal mice of the same strain, untreated MPSVII mice, and normal mice overexpressing human GUSB for the presence of tumors and increased hepatocyte replication. The results of these studies do not indicate that MPSVII mice or mice overexpressing human GUSB are susceptible to tumor formation; however, the number of animals examined is too small to draw definitive conclusions. Results from quantitative PCR performed on the tumor samples suggest that the tumors are probably not caused by an insertional mutagenesis event followed by the clonal expansion of a transformed cell. In a separate study, a relatively large group of mice injected with varying doses and types of rAAV vectors had no evidence of hepatic or vascular tumors. Although the mechanism of tumor formation is currently unknown, the tumorigenic potential of rAAV vectors must be rigorously determined in long-term in vivo studies." @default.
• W2088797435 created "2016-06-24" @default.
• W2088797435 creator A5010005871 @default.
• W2088797435 creator A5019848579 @default.
• W2088797435 creator A5028151703 @default.
• W2088797435 creator A5035217898 @default.
• W2088797435 creator A5041184253 @default.
• W2088797435 creator A5049345275 @default.
• W2088797435 creator A5055932714 @default.
• W2088797435 creator A5082333244 @default.
• W2088797435 creator A5090006240 @default.
• W2088797435 date "2001-09-01" @default.
• W2088797435 modified "2023-10-15" @default.
• W2088797435 title "Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors" @default.
• W2088797435 cites W1541926252 @default.
• W2088797435 cites W1970030078 @default.
• W2088797435 cites W2006038562 @default.
• W2088797435 cites W2025728946 @default.
• W2088797435 cites W2028607742 @default.
• W2088797435 cites W2048162805 @default.
• W2088797435 cites W2050821526 @default.
• W2088797435 cites W2051159468 @default.
• W2088797435 cites W2070252374 @default.
• W2088797435 cites W2073304593 @default.
• W2088797435 cites W2109305605 @default.
• W2088797435 cites W2159706578 @default.
• W2088797435 cites W2330486247 @default.
• W2088797435 doi "https://doi.org/10.1038/sj.gt.3301541" @default.
• W2088797435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11571571" @default.
• W2088797435 hasPublicationYear "2001" @default.
• W2088797435 type Work @default.
• W2088797435 sameAs 2088797435 @default.
• W2088797435 citedByCount "255" @default.
• W2088797435 countsByYear W20887974352012 @default.
• W2088797435 countsByYear W20887974352013 @default.
• W2088797435 countsByYear W20887974352014 @default.
• W2088797435 countsByYear W20887974352015 @default.
• W2088797435 countsByYear W20887974352016 @default.
• W2088797435 countsByYear W20887974352017 @default.
• W2088797435 countsByYear W20887974352018 @default.
• W2088797435 countsByYear W20887974352019 @default.
• W2088797435 countsByYear W20887974352020 @default.
• W2088797435 countsByYear W20887974352021 @default.
• W2088797435 countsByYear W20887974352022 @default.
• W2088797435 countsByYear W20887974352023 @default.
• W2088797435 crossrefType "journal-article" @default.
• W2088797435 hasAuthorship W2088797435A5010005871 @default.
• W2088797435 hasAuthorship W2088797435A5019848579 @default.
• W2088797435 hasAuthorship W2088797435A5028151703 @default.
• W2088797435 hasAuthorship W2088797435A5035217898 @default.
• W2088797435 hasAuthorship W2088797435A5041184253 @default.
• W2088797435 hasAuthorship W2088797435A5049345275 @default.
• W2088797435 hasAuthorship W2088797435A5055932714 @default.
• W2088797435 hasAuthorship W2088797435A5082333244 @default.
• W2088797435 hasAuthorship W2088797435A5090006240 @default.
• W2088797435 hasBestOaLocation W20887974351 @default.
• W2088797435 hasConcept C104317684 @default.
• W2088797435 hasConcept C107635520 @default.
• W2088797435 hasConcept C111599444 @default.
• W2088797435 hasConcept C126322002 @default.
• W2088797435 hasConcept C143065580 @default.
• W2088797435 hasConcept C153911025 @default.
• W2088797435 hasConcept C159047783 @default.
• W2088797435 hasConcept C203014093 @default.
• W2088797435 hasConcept C2778019345 @default.
• W2088797435 hasConcept C2911091166 @default.
• W2088797435 hasConcept C32470452 @default.
• W2088797435 hasConcept C40767141 @default.
• W2088797435 hasConcept C502942594 @default.
• W2088797435 hasConcept C54355233 @default.
• W2088797435 hasConcept C555283112 @default.
• W2088797435 hasConcept C71924100 @default.
• W2088797435 hasConcept C86803240 @default.
• W2088797435 hasConceptScore W2088797435C104317684 @default.
• W2088797435 hasConceptScore W2088797435C107635520 @default.
• W2088797435 hasConceptScore W2088797435C111599444 @default.
• W2088797435 hasConceptScore W2088797435C126322002 @default.
• W2088797435 hasConceptScore W2088797435C143065580 @default.
• W2088797435 hasConceptScore W2088797435C153911025 @default.
• W2088797435 hasConceptScore W2088797435C159047783 @default.
• W2088797435 hasConceptScore W2088797435C203014093 @default.
• W2088797435 hasConceptScore W2088797435C2778019345 @default.
• W2088797435 hasConceptScore W2088797435C2911091166 @default.
• W2088797435 hasConceptScore W2088797435C32470452 @default.
• W2088797435 hasConceptScore W2088797435C40767141 @default.
• W2088797435 hasConceptScore W2088797435C502942594 @default.
• W2088797435 hasConceptScore W2088797435C54355233 @default.
• W2088797435 hasConceptScore W2088797435C555283112 @default.
• W2088797435 hasConceptScore W2088797435C71924100 @default.
• W2088797435 hasConceptScore W2088797435C86803240 @default.
• W2088797435 hasIssue "17" @default.
• W2088797435 hasLocation W20887974351 @default.
• W2088797435 hasLocation W20887974352 @default.
• W2088797435 hasOpenAccess W2088797435 @default.
• W2088797435 hasPrimaryLocation W20887974351 @default.
• W2088797435 hasRelatedWork W1587611090 @default.
• W2088797435 hasRelatedWork W1602083480 @default.
• W2088797435 hasRelatedWork W1981421312 @default.

• next