FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088804964> ?p ?o ?g. }

• W2088804964 endingPage "7" @default.
• W2088804964 startingPage "1" @default.
• W2088804964 abstract "Aim . The aim of this study was to establish population pharmacokinetic models of tacrolimus in Chinese adult liver transplantation patients. Methods . Tacrolimus dose and concentration data <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mo stretchy=false>(</mml:mo><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>435</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math> were obtained from 47 Chinese adult liver transplant recipients, and the data were analyzed using a nonlinear mixed-effect modeling (NONMEM) method. Results . The structural model was a two-compartment model with first-order absorption. The typical population values of tacrolimus for the pharmacokinetic parameters of apparent clearance (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mtext>CL</mml:mtext><mml:mo>/</mml:mo><mml:mi>F</mml:mi></mml:math>), apparent distribution volume of the central compartment (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:msub><mml:mrow><mml:mi>V</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub><mml:mo>/</mml:mo><mml:mi>F</mml:mi></mml:math>), intercompartmental clearance (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>Q</mml:mi><mml:mo>/</mml:mo><mml:mi>F</mml:mi></mml:math>), apparent distribution volume of the peripheral compartment (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:msub><mml:mrow><mml:mi>V</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub><mml:mo>/</mml:mo><mml:mi>F</mml:mi></mml:math>), and absorption rate (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mrow><mml:msub><mml:mrow><mml:mi>k</mml:mi></mml:mrow><mml:mrow><mml:mi>a</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>) were 11.2 L/h, 406 L, 57.3 L/h, 503 L, and 0.723 h −1 , respectively. The interindividual variabilities of these parameters were 16.2%, 163%, 19.7%, 199%, and 74.3%, respectively, and the intraindividual variability of observed concentration was 26.54%. The covariates retained in the final models were postoperative days (POD) and dosage per day (DOSE) on <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mtext>CL</mml:mtext><mml:mo>/</mml:mo><mml:mi>F</mml:mi></mml:math>. Conclusion . Population pharmacokinetic models of tacrolimus were developed in Chinese adult liver transplant patients. These results could provide the interpretation of the outcome of pharmacokinetics modeling and the impact of covariate tested on individualized tacrolimus therapy." @default.
• W2088804964 created "2016-06-24" @default.
• W2088804964 creator A5015568577 @default.
• W2088804964 creator A5030168652 @default.
• W2088804964 creator A5045203166 @default.
• W2088804964 creator A5062419439 @default.
• W2088804964 creator A5073880929 @default.
• W2088804964 creator A5080725149 @default.
• W2088804964 creator A5084033026 @default.
• W2088804964 date "2014-02-13" @default.
• W2088804964 modified "2023-10-18" @default.
• W2088804964 title "The Population Pharmacokinetic Models of Tacrolimus in Chinese Adult Liver Transplantation Patients" @default.
• W2088804964 cites W1699192476 @default.
• W2088804964 cites W1925142268 @default.
• W2088804964 cites W1971855647 @default.
• W2088804964 cites W1976392571 @default.
• W2088804964 cites W1982607095 @default.
• W2088804964 cites W1993600048 @default.
• W2088804964 cites W1995752230 @default.
• W2088804964 cites W2000234125 @default.
• W2088804964 cites W2017618070 @default.
• W2088804964 cites W2022934702 @default.
• W2088804964 cites W2024318802 @default.
• W2088804964 cites W2038989721 @default.
• W2088804964 cites W2066471713 @default.
• W2088804964 cites W2068650301 @default.
• W2088804964 cites W2083594960 @default.
• W2088804964 cites W2084186021 @default.
• W2088804964 cites W2085481489 @default.
• W2088804964 cites W2089437137 @default.
• W2088804964 cites W2091718723 @default.
• W2088804964 cites W2097887921 @default.
• W2088804964 cites W2163636362 @default.
• W2088804964 cites W2331816066 @default.
• W2088804964 cites W2768259672 @default.
• W2088804964 cites W4211179245 @default.
• W2088804964 doi "https://doi.org/10.1155/2014/713650" @default.
• W2088804964 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4590802" @default.
• W2088804964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26556199" @default.
• W2088804964 hasPublicationYear "2014" @default.
• W2088804964 type Work @default.
• W2088804964 sameAs 2088804964 @default.
• W2088804964 citedByCount "11" @default.
• W2088804964 countsByYear W20888049642014 @default.
• W2088804964 countsByYear W20888049642016 @default.
• W2088804964 countsByYear W20888049642019 @default.
• W2088804964 countsByYear W20888049642021 @default.
• W2088804964 countsByYear W20888049642022 @default.
• W2088804964 countsByYear W20888049642023 @default.
• W2088804964 crossrefType "journal-article" @default.
• W2088804964 hasAuthorship W2088804964A5015568577 @default.
• W2088804964 hasAuthorship W2088804964A5030168652 @default.
• W2088804964 hasAuthorship W2088804964A5045203166 @default.
• W2088804964 hasAuthorship W2088804964A5062419439 @default.
• W2088804964 hasAuthorship W2088804964A5073880929 @default.
• W2088804964 hasAuthorship W2088804964A5080725149 @default.
• W2088804964 hasAuthorship W2088804964A5084033026 @default.
• W2088804964 hasBestOaLocation W20888049641 @default.
• W2088804964 hasConcept C11413529 @default.
• W2088804964 hasConcept C2908647359 @default.
• W2088804964 hasConcept C41008148 @default.
• W2088804964 hasConcept C71924100 @default.
• W2088804964 hasConcept C99454951 @default.
• W2088804964 hasConceptScore W2088804964C11413529 @default.
• W2088804964 hasConceptScore W2088804964C2908647359 @default.
• W2088804964 hasConceptScore W2088804964C41008148 @default.
• W2088804964 hasConceptScore W2088804964C71924100 @default.
• W2088804964 hasConceptScore W2088804964C99454951 @default.
• W2088804964 hasLocation W20888049641 @default.
• W2088804964 hasLocation W20888049642 @default.
• W2088804964 hasLocation W20888049643 @default.
• W2088804964 hasLocation W20888049644 @default.
• W2088804964 hasOpenAccess W2088804964 @default.
• W2088804964 hasPrimaryLocation W20888049641 @default.
• W2088804964 hasRelatedWork W2051487156 @default.
• W2088804964 hasRelatedWork W2052122378 @default.
• W2088804964 hasRelatedWork W2053286651 @default.
• W2088804964 hasRelatedWork W2073681303 @default.
• W2088804964 hasRelatedWork W2317200988 @default.
• W2088804964 hasRelatedWork W2544423928 @default.
• W2088804964 hasRelatedWork W2947381795 @default.
• W2088804964 hasRelatedWork W2181413294 @default.
• W2088804964 hasRelatedWork W2181743346 @default.
• W2088804964 hasRelatedWork W2187401768 @default.
• W2088804964 hasVolume "2014" @default.
• W2088804964 isParatext "false" @default.
• W2088804964 isRetracted "false" @default.
• W2088804964 magId "2088804964" @default.
• W2088804964 workType "article" @default.