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- W2088806002 abstract "1) To assess normal curvature of the upper and lower boundaries of the corpus callosum (CC) during pregnancy and to present a reference curve. 2) To assess the curvature of the CC among fetuses with abnormal US and MRI findings. A retrospective study was designed and two groups of fetuses were included. The first group included 77 normal fetuses between 28–36 weeks gestation. Those fetuses had normal US and MRI results and were divided into 3 sub groups according to gestational age: 28–30 weeks (16 fetuses), 31–33 weeks (43 fetuses) and 34–36 (18 fetuses). Neurological examination was performed in 14/77 children at 4–5 years age old, and normal results were obtained. The second group included 29 fetuses with abnormal brain US and MRI findings. Curvature of the CC was studied with a computerized soft tool designed for this purpose. This soft tool enabled to translate the digital mark of the image of the CC to a mathematical model. Mean curvature and standard deviation at 51 points along the upper and lower boundary of the CC were calculated and reference curve was performed. In order to compare statistically curvature changes during gestational age and among fetuses with abnormal brain findings, 14 different points in the CC were evaluated. In 12 out of 14 points used to compare CC curvature between different age groups, no significant differences were found. Only 2 points were significantly different between fetuses at 28–30 weeks gestation and the other 2 groups. These differences were demonstrated at the curvature at the upper boundary area of the middle callosal body and at the inferior part of the anterior callosal body. No differences were found in the CC curvature with brain anomalies. Curvature of the CC is described here for the first time in the literature. The curvature was found to be steady during 28–36 weeks gestation. No differences were found between the normal fetuses and the fetuses with brain pathologies such as ventriculomegaly." @default.
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- W2088806002 date "2010-10-01" @default.
- W2088806002 modified "2023-09-27" @default.
- W2088806002 title "OP05.04: Evaluation of the curvature of fetal corpus callosum using MRI" @default.
- W2088806002 doi "https://doi.org/10.1002/uog.7967" @default.
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