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- W2088809441 abstract "The antimetastatic activities of synthetic peptides corresponding to fragments of the adhesion-related molecules, such as flbronectin and laminin, were examined. We prepared three peptides derived from the type III connecting segment domain (IIICS) of flbronectin: Glullo-Leu-Asp-Val (EILDV), Qlu-lle-Leu-Aap-Val-Pro-Ser-Thr (EILDVPST), Arg-Qlu-Aap-Val (REDV), and a lamlnln-re-lated peptide, Tyr-lle-Gly-Ser-Arg (YIGSR). Each peptide inhibited the experimental tumor metastasis of B16-BL6 melanoma, while EILDV had the strongest effect. The peptides conjugated with poly(ethylene glycol) (PEG) were more effective than the unmodified peptides in molar ratio terms. A mixture composed of PEG hybrids with EILDV, REDV and YIGSR significantly Inhibited tumor metastasis." @default.
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- W2088809441 date "1994-08-01" @default.
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- W2088809441 title "Antimetastatic effects of synthetic peptides containing the core sequence of the type III connecting segment domain (IIICS) of fibronectin" @default.
- W2088809441 doi "https://doi.org/10.1097/00001813-199408000-00006" @default.
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