FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088811240> ?p ?o ?g. }

• W2088811240 endingPage "153" @default.
• W2088811240 startingPage "139" @default.
• W2088811240 abstract "Cancer is the second leading cause of death by disease in the world. Chemotherapy is one of three major therapeutic methods for cancer treatment, but cancer cells gradually evolve resistance to chemotherapeutic reagents. For centuries, traditional Chinese medicine (TCM) was used to fight against cancer. In recent years, a number of effective component mechanisms of TCM have been increasingly illuminated. As we know, chemical structures of reagents decide or affect their activities on target pathways. Thus, we classified some antitumor-related TCM components reported in the last five years into thirteen groups by their chemical structures, such as, alkaloids, diterpenoids, triterpenes, sesquiterpenes, anthraquinones, benzoquinones, flavonoids, berbamines, xanthones, saponins, steroids, polysaccharides, and glycosides. In various cancer cell lines, these constituents target dozens of signaling pathways in vitro and in vivo. Among these components, there are three sets: i) mainly apoptosis-related groups, such as, alkaloids, diterpenoids, anthraquinones, berbamines, and xanthones, target pathways like the mitochondrial pathway, NF-κB pathway, p53 pathway and so on; ii) mainly proliferation, invasion and metastasis-related groups, such as, triterpenes, sesquiterpenes, polysaccharides, and glycosides, target pathways like the mTOR pathway, β-catenin pathway, ERK pathway and so on; iii) both apoptosis and proliferation, invasion and metastasis-related groups, such as benzoquinones, flavonoids, saponins, and steroids, target the pathways in i) and ii) synchronously. These will provide association information between TCM components and signaling pathways to promote studies on mechanisms of effective constituents, target drug development, and combinational chemotherapy. TCM could be alternative medicine for cancer treatment in the future." @default.
• W2088811240 created "2016-06-24" @default.
• W2088811240 creator A5007634021 @default.
• W2088811240 creator A5015177224 @default.
• W2088811240 creator A5028580598 @default.
• W2088811240 creator A5028862176 @default.
• W2088811240 creator A5069571261 @default.
• W2088811240 creator A5077960542 @default.
• W2088811240 date "2014-01-01" @default.
• W2088811240 modified "2023-10-01" @default.
• W2088811240 title "A map describing the association between effective components of traditional Chinese medicine and signaling pathways in cancer cells in vitro and in vivo" @default.
• W2088811240 cites W158491552 @default.
• W2088811240 cites W1603871693 @default.
• W2088811240 cites W1778255972 @default.
• W2088811240 cites W1897257409 @default.
• W2088811240 cites W1945808363 @default.
• W2088811240 cites W1966802465 @default.
• W2088811240 cites W1970968696 @default.
• W2088811240 cites W1974524697 @default.
• W2088811240 cites W1975171439 @default.
• W2088811240 cites W1976271889 @default.
• W2088811240 cites W1984476426 @default.
• W2088811240 cites W1984918775 @default.
• W2088811240 cites W1985303190 @default.
• W2088811240 cites W1985731139 @default.
• W2088811240 cites W1986459600 @default.
• W2088811240 cites W1986674043 @default.
• W2088811240 cites W1988645824 @default.
• W2088811240 cites W1989872211 @default.
• W2088811240 cites W1990118372 @default.
• W2088811240 cites W1992224451 @default.
• W2088811240 cites W1992478508 @default.
• W2088811240 cites W1993805009 @default.
• W2088811240 cites W1994341587 @default.
• W2088811240 cites W1994922120 @default.
• W2088811240 cites W1996701280 @default.
• W2088811240 cites W1997711343 @default.
• W2088811240 cites W1998029460 @default.
• W2088811240 cites W1999775786 @default.
• W2088811240 cites W2000380789 @default.
• W2088811240 cites W2001212363 @default.
• W2088811240 cites W2002196794 @default.
• W2088811240 cites W2007392009 @default.
• W2088811240 cites W2008054370 @default.
• W2088811240 cites W2008719379 @default.
• W2088811240 cites W2009879133 @default.
• W2088811240 cites W2011956986 @default.
• W2088811240 cites W2012439721 @default.
• W2088811240 cites W2015125784 @default.
• W2088811240 cites W2015713946 @default.
• W2088811240 cites W2016808773 @default.
• W2088811240 cites W2019878158 @default.
• W2088811240 cites W2023473357 @default.
• W2088811240 cites W2025049944 @default.
• W2088811240 cites W2025132428 @default.
• W2088811240 cites W2027616638 @default.
• W2088811240 cites W2028216308 @default.
• W2088811240 cites W2032152860 @default.
• W2088811240 cites W2034937845 @default.
• W2088811240 cites W2038621908 @default.
• W2088811240 cites W2041256397 @default.
• W2088811240 cites W2043262930 @default.
• W2088811240 cites W2043345038 @default.
• W2088811240 cites W2045390594 @default.
• W2088811240 cites W2046728558 @default.
• W2088811240 cites W2047052596 @default.
• W2088811240 cites W2049843705 @default.
• W2088811240 cites W2050430721 @default.
• W2088811240 cites W2050725858 @default.
• W2088811240 cites W2051758351 @default.
• W2088811240 cites W2052274644 @default.
• W2088811240 cites W2053271344 @default.
• W2088811240 cites W2056239762 @default.
• W2088811240 cites W2056717107 @default.
• W2088811240 cites W2057164395 @default.
• W2088811240 cites W2057175984 @default.
• W2088811240 cites W2058169637 @default.
• W2088811240 cites W2059000264 @default.
• W2088811240 cites W2060762629 @default.
• W2088811240 cites W2064402835 @default.
• W2088811240 cites W2066805140 @default.
• W2088811240 cites W2069847601 @default.
• W2088811240 cites W2073105015 @default.
• W2088811240 cites W2075011718 @default.
• W2088811240 cites W2075149491 @default.
• W2088811240 cites W2075658406 @default.
• W2088811240 cites W2077293849 @default.
• W2088811240 cites W2079792950 @default.
• W2088811240 cites W2081657255 @default.
• W2088811240 cites W2084677905 @default.
• W2088811240 cites W2088876286 @default.
• W2088811240 cites W2090658654 @default.
• W2088811240 cites W2092023320 @default.
• W2088811240 cites W2092161899 @default.
• W2088811240 cites W2092532047 @default.
• W2088811240 cites W2094724784 @default.
• W2088811240 cites W2095383156 @default.
• W2088811240 cites W2098537494 @default.

• next