FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088815501> ?p ?o ?g. }

• W2088815501 abstract "Positron Emission Tomography (PET) is a powerful functional imaging technique targeted for in vivo quantification and localization of physiological and pathophysiological functions. The possibility to develop a vast number of diseases in transgenic and knockout mice, and the chance to follow the onset of the diseases and the evolution of the treatment efficacy in an individual basis, made PET the third preferred preclinical imaging technique (20%) in research and development of new drug therapies [1]. Two features are mandatory in a preclinical PET system: a high Full Width at Half Maximum (FWHM) Spatial Resolution (SR), comprised between 0.40 and 0.27 mm for mice, so as to achieve the same level of detail of current state-of-the art PET scanners for humans [2], and a sensitivity as high as possible, to allow to differentiate and quantify a subtle signal in the presence of significant background counts [3]. Commercially available state-of-the-art preclinical PET systems make use of detectors based on segmented inorganic scintillation crystals coupled to photodetectors [2]. To reduce the complexity and cost, light multiplexing is used to decode the position of interaction of annihilation photons [3]. This scheme poses some limitations to the sensitivity and SR attained by preclinical PET systems, due to, among other problems, the difficulty of measuring efficiently the Depth-Of-Interaction [3]. The best reported values for the sensitivity and SR of current commercially available preclinical PET systems, are of, respectively, ∼10% and ∼1 mm FWHM [2]. Timing Resistive Plate Chambers (RPCs) are gaseous detectors with resistive parallel plate electrodes (made of glass) separated by small (∼300 μm thick) and precise amplification gaps filled with an appropriate gas mixture. For the detection of photons, these are first converted into electrons in the resistive plates in an electronic cascade process. Some of the originated electrons will eventually escape to the amplification gap, where they will be accelerated by a uniform electric field, leading to a Townsend avalanche, which induces a current in a set of signal pickup strips. These low cost detectors have an excellent time resolution of 300 ps FWHM for 511 keV photon pairs, an excellent intrinsic SR, the readout being in almost full 3D mode. Recently, we developed a first fully functional prototype of a preclinical RPC-PET scanner for mice, which revealed a SR of 0.4 mm FWHM after image reconstruction by a Maximum Likelihood Expectation Maximization type algorithm. Preliminary tests with mice, preformed at the Institute of Nuclear Sciences Applied to Health (ICNAS — Instituto de Ciencias Nucleares Aplicada as Saude) of the University of Coimbra, shown the capability of the system to clearly identify the very small brain structures of mice, as well as the heart walls. The results obtained thus far are very promising, revealing unprecedented SR." @default.
• W2088815501 created "2016-06-24" @default.
• W2088815501 creator A5004317274 @default.
• W2088815501 creator A5006713859 @default.
• W2088815501 creator A5021824433 @default.
• W2088815501 creator A5030040711 @default.
• W2088815501 creator A5031765383 @default.
• W2088815501 creator A5035886908 @default.
• W2088815501 creator A5037908121 @default.
• W2088815501 creator A5039267388 @default.
• W2088815501 creator A5039309191 @default.
• W2088815501 creator A5051424263 @default.
• W2088815501 creator A5060446958 @default.
• W2088815501 creator A5066732273 @default.
• W2088815501 creator A5068355518 @default.
• W2088815501 creator A5077209404 @default.
• W2088815501 creator A5087095648 @default.
• W2088815501 date "2015-02-01" @default.
• W2088815501 modified "2023-09-25" @default.
• W2088815501 title "An ultra-high resolution preclinical positron emission tomography scanner" @default.
• W2088815501 cites W1964408641 @default.
• W2088815501 cites W2146006128 @default.
• W2088815501 doi "https://doi.org/10.1109/enbeng.2015.7088828" @default.
• W2088815501 hasPublicationYear "2015" @default.
• W2088815501 type Work @default.
• W2088815501 sameAs 2088815501 @default.
• W2088815501 citedByCount "0" @default.
• W2088815501 crossrefType "proceedings-article" @default.
• W2088815501 hasAuthorship W2088815501A5004317274 @default.
• W2088815501 hasAuthorship W2088815501A5006713859 @default.
• W2088815501 hasAuthorship W2088815501A5021824433 @default.
• W2088815501 hasAuthorship W2088815501A5030040711 @default.
• W2088815501 hasAuthorship W2088815501A5031765383 @default.
• W2088815501 hasAuthorship W2088815501A5035886908 @default.
• W2088815501 hasAuthorship W2088815501A5037908121 @default.
• W2088815501 hasAuthorship W2088815501A5039267388 @default.
• W2088815501 hasAuthorship W2088815501A5039309191 @default.
• W2088815501 hasAuthorship W2088815501A5051424263 @default.
• W2088815501 hasAuthorship W2088815501A5060446958 @default.
• W2088815501 hasAuthorship W2088815501A5066732273 @default.
• W2088815501 hasAuthorship W2088815501A5068355518 @default.
• W2088815501 hasAuthorship W2088815501A5077209404 @default.
• W2088815501 hasAuthorship W2088815501A5087095648 @default.
• W2088815501 hasConcept C102637530 @default.
• W2088815501 hasConcept C108649604 @default.
• W2088815501 hasConcept C120665830 @default.
• W2088815501 hasConcept C121332964 @default.
• W2088815501 hasConcept C136229726 @default.
• W2088815501 hasConcept C136339569 @default.
• W2088815501 hasConcept C150903083 @default.
• W2088815501 hasConcept C161694136 @default.
• W2088815501 hasConcept C19275194 @default.
• W2088815501 hasConcept C19527891 @default.
• W2088815501 hasConcept C205372480 @default.
• W2088815501 hasConcept C207001950 @default.
• W2088815501 hasConcept C2775842073 @default.
• W2088815501 hasConcept C2779751349 @default.
• W2088815501 hasConcept C2780330291 @default.
• W2088815501 hasConcept C29331040 @default.
• W2088815501 hasConcept C2989005 @default.
• W2088815501 hasConcept C41008148 @default.
• W2088815501 hasConcept C71924100 @default.
• W2088815501 hasConcept C76155785 @default.
• W2088815501 hasConcept C86803240 @default.
• W2088815501 hasConcept C94915269 @default.
• W2088815501 hasConceptScore W2088815501C102637530 @default.
• W2088815501 hasConceptScore W2088815501C108649604 @default.
• W2088815501 hasConceptScore W2088815501C120665830 @default.
• W2088815501 hasConceptScore W2088815501C121332964 @default.
• W2088815501 hasConceptScore W2088815501C136229726 @default.
• W2088815501 hasConceptScore W2088815501C136339569 @default.
• W2088815501 hasConceptScore W2088815501C150903083 @default.
• W2088815501 hasConceptScore W2088815501C161694136 @default.
• W2088815501 hasConceptScore W2088815501C19275194 @default.
• W2088815501 hasConceptScore W2088815501C19527891 @default.
• W2088815501 hasConceptScore W2088815501C205372480 @default.
• W2088815501 hasConceptScore W2088815501C207001950 @default.
• W2088815501 hasConceptScore W2088815501C2775842073 @default.
• W2088815501 hasConceptScore W2088815501C2779751349 @default.
• W2088815501 hasConceptScore W2088815501C2780330291 @default.
• W2088815501 hasConceptScore W2088815501C29331040 @default.
• W2088815501 hasConceptScore W2088815501C2989005 @default.
• W2088815501 hasConceptScore W2088815501C41008148 @default.
• W2088815501 hasConceptScore W2088815501C71924100 @default.
• W2088815501 hasConceptScore W2088815501C76155785 @default.
• W2088815501 hasConceptScore W2088815501C86803240 @default.
• W2088815501 hasConceptScore W2088815501C94915269 @default.
• W2088815501 hasLocation W20888155011 @default.
• W2088815501 hasOpenAccess W2088815501 @default.
• W2088815501 hasPrimaryLocation W20888155011 @default.
• W2088815501 hasRelatedWork W1171831391 @default.
• W2088815501 hasRelatedWork W1486317969 @default.
• W2088815501 hasRelatedWork W1869379179 @default.
• W2088815501 hasRelatedWork W2047099284 @default.
• W2088815501 hasRelatedWork W2052098435 @default.
• W2088815501 hasRelatedWork W2061536862 @default.
• W2088815501 hasRelatedWork W2068846271 @default.
• W2088815501 hasRelatedWork W2122238683 @default.
• W2088815501 hasRelatedWork W2170159522 @default.
• W2088815501 hasRelatedWork W2178339195 @default.

• next