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- W2088817857 abstract "Iodination of thyroglobulin is the key step of thyroid hormone biosynthesis. It is catalyzed by thyroid peroxidase and occurs within the follicular space at the apical plasma membrane. Hydrogen peroxide produced by thyrocytes as an oxidant for iodide may compromise cellular and genomic integrity of the surrounding cells, unless these are sufficiently protected by peroxidases. Thus, peroxidases play two opposing roles in thyroid biology. Both aspects of peroxide biology in the thyroid are separated in space and time and respond to the different physiological states of the thyrocytes. Redox-protective peroxidases in the thyroid are peroxiredoxins, glutathione peroxidases, and catalase. Glutathione peroxidases are selenoenzymes, whereas selenium-independent peroxiredoxins are functionally linked to the selenoenzymes of the thioredoxin reductase family through their thioredoxin cofactors. Thus, selenium impacts directly and indirectly on protective enzymes in the thyroid, a link that has been supported by animal experiments and clinical observations. In view of this relationship, it is remarkable that rather little is known about selenoprotein expression and their potential functional roles in the thyroid. Moreover, selenium-dependent and -independent peroxidases have rarely been examined in the same studies. Therefore, we review the relevant literature and present expression data of both selenium-dependent and -independent peroxidases in the murine thyroid." @default.
- W2088817857 created "2016-06-24" @default.
- W2088817857 creator A5019435104 @default.
- W2088817857 creator A5052536282 @default.
- W2088817857 creator A5087030967 @default.
- W2088817857 date "2008-09-01" @default.
- W2088817857 modified "2023-10-16" @default.
- W2088817857 title "Peroxides and Peroxide-Degrading Enzymes in the Thyroid" @default.
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- W2088817857 doi "https://doi.org/10.1089/ars.2008.2054" @default.
- W2088817857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18498223" @default.
- W2088817857 hasPublicationYear "2008" @default.
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