FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088822805> ?p ?o ?g. }

• W2088822805 endingPage "1776" @default.
• W2088822805 startingPage "1766" @default.
• W2088822805 abstract "Peptide: N -glycanases (PNGases) are cytoplasmic de- N -glycosylation enzymes that have been shown in cultured cells to facilitate the degradation of misfolded glycoproteins during endoplasmic reticulum-associated degradation and in the processing of major histocompatibility complex class I antigens for proper cell-surface presentation. The gene encoding PNGase activity was initially described in budding yeast (Png1p) and shown to be highly conserved from yeast to humans, but physiological roles in higher organisms have not been elucidated. Here we describe peripheral nervous system defects associated with the first loss-of-function mutations in an animal PNGase. Mutations in png-1 , the Caenorhabditis elegans PNGase ortholog, result in an increase in axon branching during morphogenesis of the vulval egg-laying organ and egg-laying behavior changes. Neuronal defects include an increase in the branched morphology of the VC4 and VC5 egg-laying neurons as well as inappropriate branches from axons that run adjacent to the vulva but would normally remain unbranched. We show that png-1 is widely expressed and can act from both neurons and epithelial cells to restrict axon branching. A deletion allele of the DNA repair gene rad-23 , orthologs of which are known to physically interact with PNGases in yeast and mammals, displays similar axon branching defects and genetic interactions with png-1 . In summary, our analysis reveals a novel developmental role for a PNGase and Rad-23 in the regulation of neuronal branching during organ innervation." @default.
• W2088822805 created "2016-06-24" @default.
• W2088822805 creator A5002916874 @default.
• W2088822805 creator A5012484657 @default.
• W2088822805 creator A5033225106 @default.
• W2088822805 creator A5076641056 @default.
• W2088822805 date "2010-02-03" @default.
• W2088822805 modified "2023-09-27" @default.
• W2088822805 title "The<i>N</i>-Glycanase<i>png-1</i>Acts to Limit Axon Branching during Organ Formation in Caenorhabditis elegans" @default.
• W2088822805 cites W1516264649 @default.
• W2088822805 cites W1535051467 @default.
• W2088822805 cites W1612484725 @default.
• W2088822805 cites W1642833348 @default.
• W2088822805 cites W1652342837 @default.
• W2088822805 cites W1666518235 @default.
• W2088822805 cites W1839654349 @default.
• W2088822805 cites W1964817578 @default.
• W2088822805 cites W1965843055 @default.
• W2088822805 cites W1968602397 @default.
• W2088822805 cites W1977820022 @default.
• W2088822805 cites W1982944039 @default.
• W2088822805 cites W1983413528 @default.
• W2088822805 cites W1986737010 @default.
• W2088822805 cites W1996761102 @default.
• W2088822805 cites W2012373407 @default.
• W2088822805 cites W2013921979 @default.
• W2088822805 cites W2017646239 @default.
• W2088822805 cites W2018843440 @default.
• W2088822805 cites W2019255055 @default.
• W2088822805 cites W2020634566 @default.
• W2088822805 cites W2048521206 @default.
• W2088822805 cites W2063510374 @default.
• W2088822805 cites W2068278629 @default.
• W2088822805 cites W2070482757 @default.
• W2088822805 cites W2079634353 @default.
• W2088822805 cites W2081261090 @default.
• W2088822805 cites W2083053679 @default.
• W2088822805 cites W2091038060 @default.
• W2088822805 cites W2099607192 @default.
• W2088822805 cites W2107063284 @default.
• W2088822805 cites W2119646657 @default.
• W2088822805 cites W2120599929 @default.
• W2088822805 cites W2120999957 @default.
• W2088822805 cites W2123456626 @default.
• W2088822805 cites W2125264965 @default.
• W2088822805 cites W2128625570 @default.
• W2088822805 cites W2129420942 @default.
• W2088822805 cites W2132818618 @default.
• W2088822805 cites W2133960052 @default.
• W2088822805 cites W2139990305 @default.
• W2088822805 cites W2144656588 @default.
• W2088822805 cites W2145294610 @default.
• W2088822805 cites W2153275355 @default.
• W2088822805 cites W2156770495 @default.
• W2088822805 cites W2160271740 @default.
• W2088822805 cites W2160535967 @default.
• W2088822805 cites W2162599839 @default.
• W2088822805 cites W2169210837 @default.
• W2088822805 cites W2335952796 @default.
• W2088822805 doi "https://doi.org/10.1523/jneurosci.4962-08.2010" @default.
• W2088822805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6634002" @default.
• W2088822805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20130186" @default.
• W2088822805 hasPublicationYear "2010" @default.
• W2088822805 type Work @default.
• W2088822805 sameAs 2088822805 @default.
• W2088822805 citedByCount "33" @default.
• W2088822805 countsByYear W20888228052012 @default.
• W2088822805 countsByYear W20888228052014 @default.
• W2088822805 countsByYear W20888228052015 @default.
• W2088822805 countsByYear W20888228052016 @default.
• W2088822805 countsByYear W20888228052017 @default.
• W2088822805 countsByYear W20888228052018 @default.
• W2088822805 countsByYear W20888228052019 @default.
• W2088822805 countsByYear W20888228052020 @default.
• W2088822805 countsByYear W20888228052021 @default.
• W2088822805 countsByYear W20888228052022 @default.
• W2088822805 crossrefType "journal-article" @default.
• W2088822805 hasAuthorship W2088822805A5002916874 @default.
• W2088822805 hasAuthorship W2088822805A5012484657 @default.
• W2088822805 hasAuthorship W2088822805A5033225106 @default.
• W2088822805 hasAuthorship W2088822805A5076641056 @default.
• W2088822805 hasBestOaLocation W20888228051 @default.
• W2088822805 hasConcept C104317684 @default.
• W2088822805 hasConcept C158617107 @default.
• W2088822805 hasConcept C2778944004 @default.
• W2088822805 hasConcept C2779530196 @default.
• W2088822805 hasConcept C54355233 @default.
• W2088822805 hasConcept C86803240 @default.
• W2088822805 hasConcept C95444343 @default.
• W2088822805 hasConceptScore W2088822805C104317684 @default.
• W2088822805 hasConceptScore W2088822805C158617107 @default.
• W2088822805 hasConceptScore W2088822805C2778944004 @default.
• W2088822805 hasConceptScore W2088822805C2779530196 @default.
• W2088822805 hasConceptScore W2088822805C54355233 @default.
• W2088822805 hasConceptScore W2088822805C86803240 @default.
• W2088822805 hasConceptScore W2088822805C95444343 @default.
• W2088822805 hasIssue "5" @default.
• W2088822805 hasLocation W20888228051 @default.

• next