Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088831768> ?p ?o ?g. }
- W2088831768 endingPage "254" @default.
- W2088831768 startingPage "247" @default.
- W2088831768 abstract "Chronic and acute exposure to organophosphate pesticides or related nerve agents may lead to persistent neurological and neurobehavioral effects, which cannot be explained by acetylcholinesterase (AChE) inhibition alone. In the present study, the effects of mecamylamine (2mg/kg), or atropine (10mg/kg) alone, or in combination, on the expression of nicotinic acetylcholine receptors (nAChRs) subunits, functional signs of toxicity and lethality in paraoxon-treated rats were investigated. Surviving animals were sacrificed after 48h of paraoxon administration. Paraoxon, at dosage of 1× LD50, significantly reduced expression of α(4) and β(2) nAChR subunits mRNA and protein in rat brain homogenates. Mecamylamine, efficiently prevented reduction of the α(4) and β(2) nAChR mRNA and protein in paraoxon exposed rat brains, but atropine was not efficient. Concurrent treatment with mecamylamine and atropine restored nAChRs mRNA and protein level and prevented lethality and severe involuntary movements induced by paraoxon. Nicotinic receptors antagonists may be included in the cocktail of therapeutic agents targeting the various mechanisms for neuronal injury by organophosphates." @default.
- W2088831768 created "2016-06-24" @default.
- W2088831768 creator A5017710091 @default.
- W2088831768 creator A5028643969 @default.
- W2088831768 creator A5057768549 @default.
- W2088831768 date "2008-09-01" @default.
- W2088831768 modified "2023-09-27" @default.
- W2088831768 title "Protective effects of mecamylamine and atropine against α4β2 nicotinic receptor expression and functional toxicity in paraoxon-treated rats" @default.
- W2088831768 cites W1562398969 @default.
- W2088831768 cites W1975094715 @default.
- W2088831768 cites W1984173947 @default.
- W2088831768 cites W1995409919 @default.
- W2088831768 cites W1996275540 @default.
- W2088831768 cites W2006304751 @default.
- W2088831768 cites W2013817887 @default.
- W2088831768 cites W2015156720 @default.
- W2088831768 cites W2017749725 @default.
- W2088831768 cites W2019558495 @default.
- W2088831768 cites W2019813322 @default.
- W2088831768 cites W2021139758 @default.
- W2088831768 cites W2035391418 @default.
- W2088831768 cites W2042808393 @default.
- W2088831768 cites W2045122897 @default.
- W2088831768 cites W2056736888 @default.
- W2088831768 cites W2062352381 @default.
- W2088831768 cites W2065957780 @default.
- W2088831768 cites W2069828327 @default.
- W2088831768 cites W2071215522 @default.
- W2088831768 cites W2073739604 @default.
- W2088831768 cites W2075226846 @default.
- W2088831768 cites W2077618704 @default.
- W2088831768 cites W2078633678 @default.
- W2088831768 cites W2080559472 @default.
- W2088831768 cites W2091554180 @default.
- W2088831768 cites W2091673195 @default.
- W2088831768 cites W2091900988 @default.
- W2088831768 cites W2111627512 @default.
- W2088831768 cites W2119786790 @default.
- W2088831768 cites W2120051546 @default.
- W2088831768 cites W2122868242 @default.
- W2088831768 cites W2128635872 @default.
- W2088831768 cites W2135491682 @default.
- W2088831768 cites W2138702835 @default.
- W2088831768 cites W2483271543 @default.
- W2088831768 cites W2497509974 @default.
- W2088831768 cites W90131292 @default.
- W2088831768 doi "https://doi.org/10.1016/j.etap.2008.05.003" @default.
- W2088831768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21791372" @default.
- W2088831768 hasPublicationYear "2008" @default.
- W2088831768 type Work @default.
- W2088831768 sameAs 2088831768 @default.
- W2088831768 citedByCount "4" @default.
- W2088831768 countsByYear W20888317682014 @default.
- W2088831768 countsByYear W20888317682015 @default.
- W2088831768 crossrefType "journal-article" @default.
- W2088831768 hasAuthorship W2088831768A5017710091 @default.
- W2088831768 hasAuthorship W2088831768A5028643969 @default.
- W2088831768 hasAuthorship W2088831768A5057768549 @default.
- W2088831768 hasConcept C134018914 @default.
- W2088831768 hasConcept C161176658 @default.
- W2088831768 hasConcept C170493617 @default.
- W2088831768 hasConcept C181199279 @default.
- W2088831768 hasConcept C185592680 @default.
- W2088831768 hasConcept C188987157 @default.
- W2088831768 hasConcept C22885893 @default.
- W2088831768 hasConcept C2775859210 @default.
- W2088831768 hasConcept C2776588719 @default.
- W2088831768 hasConcept C2776880047 @default.
- W2088831768 hasConcept C2777207434 @default.
- W2088831768 hasConcept C2778706303 @default.
- W2088831768 hasConcept C2778816929 @default.
- W2088831768 hasConcept C2779570518 @default.
- W2088831768 hasConcept C55493867 @default.
- W2088831768 hasConcept C6557445 @default.
- W2088831768 hasConcept C71924100 @default.
- W2088831768 hasConcept C80161118 @default.
- W2088831768 hasConcept C86803240 @default.
- W2088831768 hasConcept C98274493 @default.
- W2088831768 hasConceptScore W2088831768C134018914 @default.
- W2088831768 hasConceptScore W2088831768C161176658 @default.
- W2088831768 hasConceptScore W2088831768C170493617 @default.
- W2088831768 hasConceptScore W2088831768C181199279 @default.
- W2088831768 hasConceptScore W2088831768C185592680 @default.
- W2088831768 hasConceptScore W2088831768C188987157 @default.
- W2088831768 hasConceptScore W2088831768C22885893 @default.
- W2088831768 hasConceptScore W2088831768C2775859210 @default.
- W2088831768 hasConceptScore W2088831768C2776588719 @default.
- W2088831768 hasConceptScore W2088831768C2776880047 @default.
- W2088831768 hasConceptScore W2088831768C2777207434 @default.
- W2088831768 hasConceptScore W2088831768C2778706303 @default.
- W2088831768 hasConceptScore W2088831768C2778816929 @default.
- W2088831768 hasConceptScore W2088831768C2779570518 @default.
- W2088831768 hasConceptScore W2088831768C55493867 @default.
- W2088831768 hasConceptScore W2088831768C6557445 @default.
- W2088831768 hasConceptScore W2088831768C71924100 @default.
- W2088831768 hasConceptScore W2088831768C80161118 @default.
- W2088831768 hasConceptScore W2088831768C86803240 @default.
- W2088831768 hasConceptScore W2088831768C98274493 @default.