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• W2088849218 abstract "Monoclonal antibodies to CD3 can induce proliferation of resting T cells. In vitro this effect is dependent on the presence of monocytes. They serve as accessory cells providing a co-stimulatory signal after cross-linking of the antibody-coated TcR/CD3 complex by the Fc receptor on the monocytes. We have studied whether endothelial cells can replace monocytes with regard to (his function. Highly purified T-cell preparations were cultured in the presence of anti-CD3 antibody, purified monocytes, and human umbilical vein endothelial cells. Anti-CD3 and endothelial cells alone were unable in support T -cell proliferation, due to lack of FcR expression. Addition, however, of as few as 10110 FcR+ monocytes (0.8% of the number of T cells present) to a co-culture of T cells and endothelial cells (EC) in the presence of soluble anti-CD3 resulted in a strong proliferation of T cells. When anti-CD3 was presented in an immobilized form (coated to the culture well or to Sepharose beads), or when phytohaemagglutinin was added to the culture as a cross-linking agent, EC could support T-cell proliferation in the absence of any monocytes. We conclude that EC by themselves cannot support the proliferation of pure T cells induced by soluble anti-CD3, but are potent generators of the co-stimulatory signal(s). They provide a suitable starling material to further define this co-stimulatory activity." @default.
• W2088849218 created "2016-06-24" @default.
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• W2088849218 date "1992-04-01" @default.
• W2088849218 modified "2023-09-24" @default.
• W2088849218 title "Accessory Function of Endothelial Cells in Anti-CD3-Induced T-Cell Proliferation: Synergism with Monocytes" @default.
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• W2088849218 doi "https://doi.org/10.1111/j.1365-3083.1992.tb02880.x" @default.
• W2088849218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1532667" @default.
• W2088849218 hasPublicationYear "1992" @default.
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