Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088852871> ?p ?o ?g. }
- W2088852871 endingPage "558" @default.
- W2088852871 startingPage "535" @default.
- W2088852871 abstract "O-linked N-acetyl-β-d-glucosamine (O-GlcNAc) is a ubiquitous and dynamic post-translational modification known to modify over 3,000 nuclear, cytoplasmic, and mitochondrial eukaryotic proteins. Addition of O-GlcNAc to proteins is catalyzed by the O-GlcNAc transferase and is removed by a neutral-N-acetyl-β-glucosaminidase (O-GlcNAcase). O-GlcNAc is thought to regulate proteins in a manner analogous to protein phosphorylation, and the cycling of this carbohydrate modification regulates many cellular functions such as the cellular stress response. Diverse forms of cellular stress and tissue injury result in enhanced O-GlcNAc modification, or O-GlcNAcylation, of numerous intracellular proteins. Stress-induced O-GlcNAcylation appears to promote cell/tissue survival by regulating a multitude of biological processes including: the phosphoinositide 3-kinase/Akt pathway, heat shock protein expression, calcium homeostasis, levels of reactive oxygen species, ER stress, protein stability, mitochondrial dynamics, and inflammation. Here, we will discuss the regulation of these processes by O-GlcNAc and the impact of such regulation on survival in models of ischemia reperfusion injury and trauma hemorrhage. We will also discuss the misregulation of O-GlcNAc in diseases commonly associated with the stress response, namely Alzheimer’s and Parkinson’s diseases. Finally, we will highlight recent advancements in the tools and technologies used to study the O-GlcNAc modification." @default.
- W2088852871 created "2016-06-24" @default.
- W2088852871 creator A5038545726 @default.
- W2088852871 creator A5049888866 @default.
- W2088852871 creator A5060600015 @default.
- W2088852871 creator A5082936160 @default.
- W2088852871 date "2013-04-26" @default.
- W2088852871 modified "2023-10-16" @default.
- W2088852871 title "Dynamic O-GlcNAcylation and its roles in the cellular stress response and homeostasis" @default.
- W2088852871 cites W1481480776 @default.
- W2088852871 cites W1510239612 @default.
- W2088852871 cites W1525614980 @default.
- W2088852871 cites W1527671059 @default.
- W2088852871 cites W1550256191 @default.
- W2088852871 cites W1561390296 @default.
- W2088852871 cites W1568866400 @default.
- W2088852871 cites W1590732591 @default.
- W2088852871 cites W1600472471 @default.
- W2088852871 cites W1612870394 @default.
- W2088852871 cites W1652316604 @default.
- W2088852871 cites W1901873593 @default.
- W2088852871 cites W1903704021 @default.
- W2088852871 cites W1959097863 @default.
- W2088852871 cites W1966629811 @default.
- W2088852871 cites W1967558431 @default.
- W2088852871 cites W1968813770 @default.
- W2088852871 cites W1969513512 @default.
- W2088852871 cites W1969575348 @default.
- W2088852871 cites W1969939865 @default.
- W2088852871 cites W1970261233 @default.
- W2088852871 cites W1975320495 @default.
- W2088852871 cites W1975346170 @default.
- W2088852871 cites W1975959667 @default.
- W2088852871 cites W1976890253 @default.
- W2088852871 cites W1980659401 @default.
- W2088852871 cites W1981194148 @default.
- W2088852871 cites W1982283232 @default.
- W2088852871 cites W1982409123 @default.
- W2088852871 cites W1982416292 @default.
- W2088852871 cites W1984756562 @default.
- W2088852871 cites W1986251535 @default.
- W2088852871 cites W1986758311 @default.
- W2088852871 cites W1988220290 @default.
- W2088852871 cites W1990634680 @default.
- W2088852871 cites W1991787417 @default.
- W2088852871 cites W1992337930 @default.
- W2088852871 cites W1992665990 @default.
- W2088852871 cites W1993790829 @default.
- W2088852871 cites W1994377446 @default.
- W2088852871 cites W1994396628 @default.
- W2088852871 cites W1995418659 @default.
- W2088852871 cites W1996110302 @default.
- W2088852871 cites W1996539872 @default.
- W2088852871 cites W1997087248 @default.
- W2088852871 cites W1997569935 @default.
- W2088852871 cites W1997853510 @default.
- W2088852871 cites W1998116561 @default.
- W2088852871 cites W1998906741 @default.
- W2088852871 cites W1999351520 @default.
- W2088852871 cites W1999804990 @default.
- W2088852871 cites W2001156696 @default.
- W2088852871 cites W2001642810 @default.
- W2088852871 cites W2002871502 @default.
- W2088852871 cites W2004914600 @default.
- W2088852871 cites W2005886610 @default.
- W2088852871 cites W2008316946 @default.
- W2088852871 cites W2008832722 @default.
- W2088852871 cites W2009324889 @default.
- W2088852871 cites W2009779581 @default.
- W2088852871 cites W2009853606 @default.
- W2088852871 cites W2011652654 @default.
- W2088852871 cites W2011809164 @default.
- W2088852871 cites W2012232758 @default.
- W2088852871 cites W2013020574 @default.
- W2088852871 cites W2013832485 @default.
- W2088852871 cites W2014114236 @default.
- W2088852871 cites W2014442438 @default.
- W2088852871 cites W2015357656 @default.
- W2088852871 cites W2015990527 @default.
- W2088852871 cites W2016015885 @default.
- W2088852871 cites W2016408996 @default.
- W2088852871 cites W2017513692 @default.
- W2088852871 cites W2017548268 @default.
- W2088852871 cites W2018427433 @default.
- W2088852871 cites W2018639404 @default.
- W2088852871 cites W2020478646 @default.
- W2088852871 cites W2021745045 @default.
- W2088852871 cites W2022396367 @default.
- W2088852871 cites W2022428368 @default.
- W2088852871 cites W2024218650 @default.
- W2088852871 cites W2025379444 @default.
- W2088852871 cites W2025748859 @default.
- W2088852871 cites W2027231838 @default.
- W2088852871 cites W2029218934 @default.
- W2088852871 cites W2029586932 @default.
- W2088852871 cites W2029809948 @default.
- W2088852871 cites W2030857654 @default.
- W2088852871 cites W2031087463 @default.