FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088858249> ?p ?o ?g. }

• W2088858249 endingPage "3708" @default.
• W2088858249 startingPage "3702" @default.
• W2088858249 abstract "Based on the potential of resveratrol as a colon cancer chemopreventive agent, a set of 26 stilbenes were synthesized and tested against the colon cancer cell lines HT-29 and Caco-2. (Z)-4-(3,5-Dimethoxystyryl)aniline (4), (Z)-methyl-4-(3,5-dimethoxystyryl)benzoate (6), and (Z)-1,3-dimethoxy-5-(4-methoxystyryl)benzene (10) showed strong inhibitory activity in vitro. In vivo studies using HT-29 xenografts in immunodeficient mice were conducted with 4, 6 and 10, together with their corresponding trans isomers (3, 5, and 9, respectively), at the dose of 10 mg/kg body weight. Tumor volume was significantly lowered in 3-, 4-, and 9-treated groups. The cis- and trans-amino analogs (4 and 3, respectively) had similar effect on tumor growth, a 40% decrease compared to the control. Analysis of the serum revealed that 4 isomerized to 3, which may explain their similar effects in SCID mice. Stilbenes 5, 6, 9, and 10 retained their configurations in the serum. Stilbenes 6 and 10 lacked tumor-suppressive effect in SCID mice; the serum levels of these analogs were low (18.8 and 15.5 ng/mL, respectively). Stilbene 9, while weakly active in vitro demonstrated good activity in vivo, was found at higher levels in the serum (69.9 ng/mL) compared to 10. The anti-tumorigenic activity of these stilbene analogs may be partly linked to their effects on proteins involved in cell proliferation, as observed by lowered expression of proliferating cell nuclear antigen and upregulation of the cyclin-dependent kinase inhibitor, p27, in the tumor tissues. Overall, identification of the anti-tumorigenic potential of these compounds provides opportunities for their use against colorectal cancer." @default.
• W2088858249 created "2016-06-24" @default.
• W2088858249 creator A5010768963 @default.
• W2088858249 creator A5012132749 @default.
• W2088858249 creator A5022457658 @default.
• W2088858249 creator A5026891481 @default.
• W2088858249 creator A5059192590 @default.
• W2088858249 creator A5059532915 @default.
• W2088858249 creator A5065539515 @default.
• W2088858249 creator A5072563298 @default.
• W2088858249 creator A5089123215 @default.
• W2088858249 date "2010-09-01" @default.
• W2088858249 modified "2023-10-02" @default.
• W2088858249 title "In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer" @default.
• W2088858249 cites W1585701825 @default.
• W2088858249 cites W162428026 @default.
• W2088858249 cites W1969139061 @default.
• W2088858249 cites W1975867893 @default.
• W2088858249 cites W1976076756 @default.
• W2088858249 cites W1980855715 @default.
• W2088858249 cites W1981120303 @default.
• W2088858249 cites W1986856096 @default.
• W2088858249 cites W1998626485 @default.
• W2088858249 cites W2002610797 @default.
• W2088858249 cites W2006253943 @default.
• W2088858249 cites W2007869047 @default.
• W2088858249 cites W2017169708 @default.
• W2088858249 cites W2019005658 @default.
• W2088858249 cites W2036814520 @default.
• W2088858249 cites W2037723157 @default.
• W2088858249 cites W2038980294 @default.
• W2088858249 cites W2046885170 @default.
• W2088858249 cites W2057957331 @default.
• W2088858249 cites W2060106907 @default.
• W2088858249 cites W2063726085 @default.
• W2088858249 cites W2063825374 @default.
• W2088858249 cites W2069924244 @default.
• W2088858249 cites W2074933469 @default.
• W2088858249 cites W2075403828 @default.
• W2088858249 cites W2077764145 @default.
• W2088858249 cites W2086189875 @default.
• W2088858249 cites W2121619780 @default.
• W2088858249 cites W2124078306 @default.
• W2088858249 cites W2137397247 @default.
• W2088858249 cites W2147872600 @default.
• W2088858249 cites W2151440119 @default.
• W2088858249 cites W2156444438 @default.
• W2088858249 cites W2157942810 @default.
• W2088858249 cites W2158034359 @default.
• W2088858249 cites W2405144177 @default.
• W2088858249 doi "https://doi.org/10.1016/j.ejmech.2010.05.019" @default.
• W2088858249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2918699" @default.
• W2088858249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20627379" @default.
• W2088858249 hasPublicationYear "2010" @default.
• W2088858249 type Work @default.
• W2088858249 sameAs 2088858249 @default.
• W2088858249 citedByCount "48" @default.
• W2088858249 countsByYear W20888582492012 @default.
• W2088858249 countsByYear W20888582492013 @default.
• W2088858249 countsByYear W20888582492014 @default.
• W2088858249 countsByYear W20888582492015 @default.
• W2088858249 countsByYear W20888582492016 @default.
• W2088858249 countsByYear W20888582492017 @default.
• W2088858249 countsByYear W20888582492018 @default.
• W2088858249 countsByYear W20888582492019 @default.
• W2088858249 countsByYear W20888582492020 @default.
• W2088858249 countsByYear W20888582492021 @default.
• W2088858249 countsByYear W20888582492022 @default.
• W2088858249 countsByYear W20888582492023 @default.
• W2088858249 crossrefType "journal-article" @default.
• W2088858249 hasAuthorship W2088858249A5010768963 @default.
• W2088858249 hasAuthorship W2088858249A5012132749 @default.
• W2088858249 hasAuthorship W2088858249A5022457658 @default.
• W2088858249 hasAuthorship W2088858249A5026891481 @default.
• W2088858249 hasAuthorship W2088858249A5059192590 @default.
• W2088858249 hasAuthorship W2088858249A5059532915 @default.
• W2088858249 hasAuthorship W2088858249A5065539515 @default.
• W2088858249 hasAuthorship W2088858249A5072563298 @default.
• W2088858249 hasAuthorship W2088858249A5089123215 @default.
• W2088858249 hasBestOaLocation W20888582492 @default.
• W2088858249 hasConcept C104317684 @default.
• W2088858249 hasConcept C121608353 @default.
• W2088858249 hasConcept C126322002 @default.
• W2088858249 hasConcept C127561419 @default.
• W2088858249 hasConcept C150903083 @default.
• W2088858249 hasConcept C185592680 @default.
• W2088858249 hasConcept C202751555 @default.
• W2088858249 hasConcept C207001950 @default.
• W2088858249 hasConcept C2776816829 @default.
• W2088858249 hasConcept C526805850 @default.
• W2088858249 hasConcept C55493867 @default.
• W2088858249 hasConcept C62112901 @default.
• W2088858249 hasConcept C71240020 @default.
• W2088858249 hasConcept C71924100 @default.
• W2088858249 hasConcept C86803240 @default.
• W2088858249 hasConcept C98274493 @default.
• W2088858249 hasConceptScore W2088858249C104317684 @default.
• W2088858249 hasConceptScore W2088858249C121608353 @default.

• next