Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088877700> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2088877700 endingPage "A7" @default.
- W2088877700 startingPage "A3" @default.
- W2088877700 abstract "A surprising finding of the Cardiac Arrhythmia Suppression Trial (CAST), reported in 1989, is that well-tolerated and effective antiarrhythmic drugs may also be associated with an increase in mortality due to arrhythmia. Consequently, attention has been focused on the importance of the benefit-versus-risk assessment of such therapy. The benefits of antiarrhythmic therapy are reduction or elimination of arrhythmia-caused symptoms (both hemodynamic and nonhemodynamic) and of the associated risk of death. The risks of such treatment include not only noncardiac adverse effects and organ toxicity, but also early cardiac effects (proarrhythmia, heart failure, and conduction defects), as well as the newly recognized potential for late proarrhythmia or late arrhythmic death. Unfortunately, as the potential benefits of antiarrhythmic therapy increase in patients with poorer left ventricular function (owing to their being at greater risk for sudden death), the effectiveness of suppression decreases and the incidence of life-threatening complications increases. The impact of this benefit-risk profile is that the indication for most currently approved antiarrhythmic drugs needs to be limited to those patients with definite life-threatening ventricular arrhythmias that take the form of sustained ventricular tachyarrhythmias with associated hemodynamic symptoms. Broadening this indication to include patients with probable life-threatening or even possible life-threatening arrhythmias must await the availability of drugs with better benefit-risk profiles." @default.
- W2088877700 created "2016-06-24" @default.
- W2088877700 creator A5086647305 @default.
- W2088877700 date "1993-08-01" @default.
- W2088877700 modified "2023-10-14" @default.
- W2088877700 title "Indications for antiarrhythmic suppression of ventricular arrhythmias: A definition of life-threatening ventricular arrhythmias" @default.
- W2088877700 cites W1534708542 @default.
- W2088877700 cites W1841210729 @default.
- W2088877700 cites W1965469336 @default.
- W2088877700 cites W1965693851 @default.
- W2088877700 cites W1966953116 @default.
- W2088877700 cites W1972623266 @default.
- W2088877700 cites W1980263858 @default.
- W2088877700 cites W1985888466 @default.
- W2088877700 cites W1999284718 @default.
- W2088877700 cites W2016817288 @default.
- W2088877700 cites W2019768128 @default.
- W2088877700 cites W2021716008 @default.
- W2088877700 cites W2023495104 @default.
- W2088877700 cites W2035105123 @default.
- W2088877700 cites W2068166519 @default.
- W2088877700 cites W2094892482 @default.
- W2088877700 cites W2138858082 @default.
- W2088877700 cites W2614168425 @default.
- W2088877700 doi "https://doi.org/10.1016/0002-9149(93)90019-9" @default.
- W2088877700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8346724" @default.
- W2088877700 hasPublicationYear "1993" @default.
- W2088877700 type Work @default.
- W2088877700 sameAs 2088877700 @default.
- W2088877700 citedByCount "4" @default.
- W2088877700 crossrefType "journal-article" @default.
- W2088877700 hasAuthorship W2088877700A5086647305 @default.
- W2088877700 hasBestOaLocation W20888777001 @default.
- W2088877700 hasConcept C118441451 @default.
- W2088877700 hasConcept C126322002 @default.
- W2088877700 hasConcept C164705383 @default.
- W2088877700 hasConcept C177713679 @default.
- W2088877700 hasConcept C2775935837 @default.
- W2088877700 hasConcept C2777008848 @default.
- W2088877700 hasConcept C2778198053 @default.
- W2088877700 hasConcept C2993353509 @default.
- W2088877700 hasConcept C42219234 @default.
- W2088877700 hasConcept C71924100 @default.
- W2088877700 hasConceptScore W2088877700C118441451 @default.
- W2088877700 hasConceptScore W2088877700C126322002 @default.
- W2088877700 hasConceptScore W2088877700C164705383 @default.
- W2088877700 hasConceptScore W2088877700C177713679 @default.
- W2088877700 hasConceptScore W2088877700C2775935837 @default.
- W2088877700 hasConceptScore W2088877700C2777008848 @default.
- W2088877700 hasConceptScore W2088877700C2778198053 @default.
- W2088877700 hasConceptScore W2088877700C2993353509 @default.
- W2088877700 hasConceptScore W2088877700C42219234 @default.
- W2088877700 hasConceptScore W2088877700C71924100 @default.
- W2088877700 hasIssue "4" @default.
- W2088877700 hasLocation W20888777001 @default.
- W2088877700 hasLocation W20888777002 @default.
- W2088877700 hasOpenAccess W2088877700 @default.
- W2088877700 hasPrimaryLocation W20888777001 @default.
- W2088877700 hasRelatedWork W1604250740 @default.
- W2088877700 hasRelatedWork W1991508660 @default.
- W2088877700 hasRelatedWork W2059132091 @default.
- W2088877700 hasRelatedWork W2063240695 @default.
- W2088877700 hasRelatedWork W2067418531 @default.
- W2088877700 hasRelatedWork W2074159517 @default.
- W2088877700 hasRelatedWork W2170759882 @default.
- W2088877700 hasRelatedWork W2295441067 @default.
- W2088877700 hasRelatedWork W2465680524 @default.
- W2088877700 hasRelatedWork W2914679361 @default.
- W2088877700 hasVolume "72" @default.
- W2088877700 isParatext "false" @default.
- W2088877700 isRetracted "false" @default.
- W2088877700 magId "2088877700" @default.
- W2088877700 workType "article" @default.