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• W2088890601 endingPage "7093" @default.
• W2088890601 startingPage "7083" @default.
• W2088890601 abstract "Cerebral ischemic preconditioning or tolerance is a powerful neuroprotective phenomenon by which a sublethal injurious stimulus renders the brain resistant to a subsequent damaging ischemic insult. We used lipopolysaccharide (LPS) as a preconditioning stimulus in a mouse model of middle cerebral artery occlusion (MCAO) to examine whether improvements in cerebrovascular function contribute to the protective effect. Administration of LPS 24 h before MCAO reduced the infarct by 68% and improved ischemic cerebral blood flow (CBF) by 114% in brain areas spared from infarction. In addition, LPS prevented the dysfunction in cerebrovascular regulation induced by MCAO, as demonstrated by normalization of the increase in CBF produced by neural activity, hypercapnia, or by the endothelium-dependent vasodilator acetylcholine. These beneficial effects of LPS were not observed in mice lacking inducible nitric oxide synthase (iNOS) or the nox2 subunit of the superoxide-producing enzyme NADPH oxidase. LPS increased reactive oxygen species and the peroxynitrite marker 3-nitrotyrosine in wild-type mice but not in nox2 nulls. The peroxynitrite decomposition catalyst 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron (III) attenuated LPS-induced nitration and counteracted the beneficial effects of LPS on infarct volume, ischemic CBF, and vascular reactivity. Thus, LPS preserves neurovascular function and ameliorates CBF in regions of the ischemic territory at risk for infarction. This effect is mediated by peroxynitrite formed from iNOS-derived NO and nox2-derived superoxide. The data indicate that preservation of cerebrovascular function is an essential component of ischemic tolerance and suggest that combining neuroprotection and vasoprotection may be a valuable strategy for treating ischemic brain injury." @default.
• W2088890601 created "2016-06-24" @default.
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• W2088890601 date "2007-07-04" @default.
• W2088890601 modified "2023-09-25" @default.
• W2088890601 title "Neurovascular Protection by Ischemic Tolerance: Role of Nitric Oxide and Reactive Oxygen Species" @default.
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• W2088890601 cites W1964100686 @default.
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• W2088890601 cites W1970935798 @default.
• W2088890601 cites W1975406229 @default.
• W2088890601 cites W1981319792 @default.
• W2088890601 cites W1993647161 @default.
• W2088890601 cites W1999660002 @default.
• W2088890601 cites W2007353602 @default.
• W2088890601 cites W2009186035 @default.
• W2088890601 cites W2009812062 @default.
• W2088890601 cites W2010449070 @default.
• W2088890601 cites W2010661373 @default.
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• W2088890601 cites W2018022526 @default.
• W2088890601 cites W2022459524 @default.
• W2088890601 cites W2029598024 @default.
• W2088890601 cites W2032217701 @default.
• W2088890601 cites W2034779218 @default.
• W2088890601 cites W2035569448 @default.
• W2088890601 cites W2035848392 @default.
• W2088890601 cites W2037288562 @default.
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• W2088890601 cites W2077166140 @default.
• W2088890601 cites W2078390434 @default.
• W2088890601 cites W2079043570 @default.
• W2088890601 cites W2080012950 @default.
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• W2088890601 doi "https://doi.org/10.1523/jneurosci.1645-07.2007" @default.
• W2088890601 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6794575" @default.
• W2088890601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17611261" @default.
• W2088890601 hasPublicationYear "2007" @default.
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