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- W2088891222 abstract "Six pairs of female squirrel monkeys were given a daily intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for 9–14 days, beginning the same day on which they received either a bilateral 6-hydroxydopamine lesion or a sham lesion of the locus coeruleus. Sham animals developed typical parkinsonian signs (i.e. tremor, bradykinesia, hypokinesia and reduced blink rate) which largely recovered by six to nine weeks after the start of MPTP treatment. At nine weeks,post mortem levels of striatal dopamine in these same animals were partially reduced (by 45%), and this only in the putamen, compared to values obtained from three non-operated, normal control animals. Additionally, histological examination revealed a moderate loss of neuronal cell bodies in the substantia nigra, pars compacta. In marked contrast, the locus coeruleus-lesioned monkeys exhibited little or no recovery from the parkinsonian signs induced by MPTP.Post mortem examination of these animals revealed profound decreases in caudate (by 84%) and putamen (by 91%) dopamine content, and severe neuronal cell loss in the substantia nigra pars compacta of all animals. These neurological, biochemical and histological assessments indicate that lesioning of the locus coeruleus impairs the recovery which usually occurs from the parkinsonian manifestations induced by MPTP in squirrel monkeys. The results support the hypothesis that deficient locus coeruleus noradrenergic mechanisms underlie the progression of Parkinson's disease." @default.
- W2088891222 created "2016-06-24" @default.
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- W2088891222 date "1991-01-01" @default.
- W2088891222 modified "2023-10-10" @default.
- W2088891222 title "Effects of locus coeruleus lesions on parkinsonian signs, striatal dopamine and substantia nigra cell loss after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in monkeys: A possible role for the locus coeruleus in the progression of Parkinson's disease" @default.
- W2088891222 cites W1608952396 @default.
- W2088891222 cites W1927558465 @default.
- W2088891222 cites W1965058672 @default.
- W2088891222 cites W1965976103 @default.
- W2088891222 cites W1966369144 @default.
- W2088891222 cites W1969800514 @default.
- W2088891222 cites W1971092962 @default.
- W2088891222 cites W1972190053 @default.
- W2088891222 cites W1973730670 @default.
- W2088891222 cites W1974009452 @default.
- W2088891222 cites W1976606839 @default.
- W2088891222 cites W1977806931 @default.
- W2088891222 cites W1979335265 @default.
- W2088891222 cites W1980275914 @default.
- W2088891222 cites W1987320417 @default.
- W2088891222 cites W1987572299 @default.
- W2088891222 cites W1988586529 @default.
- W2088891222 cites W1990275580 @default.
- W2088891222 cites W1990294120 @default.
- W2088891222 cites W1998532128 @default.
- W2088891222 cites W2002631281 @default.
- W2088891222 cites W2004830453 @default.
- W2088891222 cites W2005578756 @default.
- W2088891222 cites W2005626706 @default.
- W2088891222 cites W2006308520 @default.
- W2088891222 cites W2007634755 @default.
- W2088891222 cites W2009874687 @default.
- W2088891222 cites W2010922134 @default.
- W2088891222 cites W2011580130 @default.
- W2088891222 cites W2012556157 @default.
- W2088891222 cites W2013427699 @default.
- W2088891222 cites W2018567612 @default.
- W2088891222 cites W2019926040 @default.
- W2088891222 cites W2022209627 @default.
- W2088891222 cites W2022869443 @default.
- W2088891222 cites W2023027749 @default.
- W2088891222 cites W2023642111 @default.
- W2088891222 cites W2035853515 @default.
- W2088891222 cites W2037024131 @default.
- W2088891222 cites W2041215369 @default.
- W2088891222 cites W2042676032 @default.
- W2088891222 cites W2046424371 @default.
- W2088891222 cites W2047795051 @default.
- W2088891222 cites W2048084523 @default.
- W2088891222 cites W2059449602 @default.
- W2088891222 cites W2060181203 @default.
- W2088891222 cites W2061495518 @default.
- W2088891222 cites W2064028650 @default.
- W2088891222 cites W2064996887 @default.
- W2088891222 cites W2066687408 @default.
- W2088891222 cites W2072190564 @default.
- W2088891222 cites W2074080728 @default.
- W2088891222 cites W2078629247 @default.
- W2088891222 cites W2081835330 @default.
- W2088891222 cites W2085915188 @default.
- W2088891222 cites W2085975745 @default.
- W2088891222 cites W2086662540 @default.
- W2088891222 cites W2087323566 @default.
- W2088891222 cites W2089376557 @default.
- W2088891222 cites W2094023488 @default.
- W2088891222 cites W2095828172 @default.
- W2088891222 cites W2101865792 @default.
- W2088891222 cites W2159102561 @default.
- W2088891222 cites W2323676024 @default.
- W2088891222 cites W2324245785 @default.
- W2088891222 cites W2336893408 @default.
- W2088891222 cites W2466549000 @default.
- W2088891222 cites W2475909490 @default.
- W2088891222 cites W4243324219 @default.
- W2088891222 cites W4243911795 @default.
- W2088891222 cites W4246856815 @default.
- W2088891222 doi "https://doi.org/10.1016/0306-4522(91)90345-o" @default.
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- W2088891222 hasPublicationYear "1991" @default.
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