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- W2088891238 abstract "Rat hepatocytes and bone marrow stromal cells (BMSCs) were cocultured with the aim of maintaining differentiated hepatocyte functions. After BMSCs were expanded to a confluent monolayer, freshly isolated hepatocytes were cultured with them, separated by a semipermeable membrane. The BMSCs significantly increased the urea synthesis and albumin secretion activities of the hepatocytes. Conditioned medium prepared from a BMSC monoculture had the same effect. Further study showed that interleukin-6 was involved in the maintenance of urea synthesis and another factor in the maintenance of albumin secretion." @default.
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- W2088891238 date "2004-01-01" @default.
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- W2088891238 title "Maintenance of hepatocyte functions by coculture with bone marrow stromal cells" @default.
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- W2088891238 doi "https://doi.org/10.1016/s1389-1723(04)70217-0" @default.
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