Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088891680> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2088891680 endingPage "625" @default.
- W2088891680 startingPage "620" @default.
- W2088891680 abstract "Free radicals are implicated with cellular disorders through their detrimental actions on proteins, lipids and DNA and are causative factors for large number of degenerative diseases and aging process. Antioxidants of plant origin hold great significance and have therefore gained utmost importance in recent past. Present investigation was a step in this direction, with an objective to comprehensively evaluate the protective effects of Helicteres isora fruits against free radicals, protein oxidation and DNA damage. Aqueous (AqE), aqueous-methanol (AqME), methanol (ME) and acetone (AE) extracts of mature pods (fruits) were obtained and concentrated in vacuo. Total phenols, flavonoids, ascorbic acid and carotenoids were estimated from extracts using standard methods. Antioxidant activities of extracts with varying concentrations (200–1000 μg/ml) were determined by total antioxidant activity (TAA), ferric reducing antioxidant power, DPPH, and OH radical scavenging assays besides lipid peroxidation inhibition. Extracts were assessed for protection against AAPH (2,2′-Azobis(2-methylpropionamidine) dihydrochloride) induced-protein oxidation using SDS-PAGE and Fenton's reagent induced-DNA damage using DNA nicking assay. The results postulated that the plant is a rich source of total phenols, flavonoids and ascorbic acid. Extracts showed concentration-dependent free radical scavenging activities and lipid peroxidation inhibition. Amongst all four extracts, AqME showed highest antioxidant potential in terms of reducing power (360 ± 5.9 gallic acid equivalent: GAE), TAA (150 ± 5.6 GAE), scavenging of free radicals including DPPH (75.6%) and OH (100%) besides maximal (97.4%) lipid peroxidation inhibition at 1000 μg/ml concentration. All the extracts barring ME effectively protected the DNA from hydroxyl radical-induced damage. Similarly, fruit extracts effectively protected the AAPH-induced-protein oxidation. H. isora fruits exhibited broad-spectrum antioxidant potencies against free radicals and significantly ameliorated various impairments associated with free radical formation including lipid peroxidation, protein oxidation and DNA damage." @default.
- W2088891680 created "2016-06-24" @default.
- W2088891680 creator A5008406792 @default.
- W2088891680 creator A5082885314 @default.
- W2088891680 creator A5085664395 @default.
- W2088891680 creator A5089527011 @default.
- W2088891680 date "2013-06-01" @default.
- W2088891680 modified "2023-09-25" @default.
- W2088891680 title "Efficacy of Helicteres isora L. against free radicals, lipid peroxidation, protein oxidation and DNA damage" @default.
- W2088891680 cites W104497545 @default.
- W2088891680 cites W1532672888 @default.
- W2088891680 cites W1965504548 @default.
- W2088891680 cites W1968126349 @default.
- W2088891680 cites W1979997754 @default.
- W2088891680 cites W1984456591 @default.
- W2088891680 cites W1985907274 @default.
- W2088891680 cites W1991387640 @default.
- W2088891680 cites W2019141992 @default.
- W2088891680 cites W2026464166 @default.
- W2088891680 cites W2031199124 @default.
- W2088891680 cites W2031496016 @default.
- W2088891680 cites W2034979815 @default.
- W2088891680 cites W2042327967 @default.
- W2088891680 cites W2053849711 @default.
- W2088891680 cites W2061479778 @default.
- W2088891680 cites W2066909110 @default.
- W2088891680 cites W2077013120 @default.
- W2088891680 cites W2084991458 @default.
- W2088891680 cites W2141449020 @default.
- W2088891680 cites W2168169067 @default.
- W2088891680 cites W2278791972 @default.
- W2088891680 cites W2467963614 @default.
- W2088891680 cites W365713858 @default.
- W2088891680 doi "https://doi.org/10.1016/j.jopr.2013.05.017" @default.
- W2088891680 hasPublicationYear "2013" @default.
- W2088891680 type Work @default.
- W2088891680 sameAs 2088891680 @default.
- W2088891680 citedByCount "9" @default.
- W2088891680 countsByYear W20888916802014 @default.
- W2088891680 countsByYear W20888916802015 @default.
- W2088891680 countsByYear W20888916802017 @default.
- W2088891680 countsByYear W20888916802019 @default.
- W2088891680 crossrefType "journal-article" @default.
- W2088891680 hasAuthorship W2088891680A5008406792 @default.
- W2088891680 hasAuthorship W2088891680A5082885314 @default.
- W2088891680 hasAuthorship W2088891680A5085664395 @default.
- W2088891680 hasAuthorship W2088891680A5089527011 @default.
- W2088891680 hasConcept C116073593 @default.
- W2088891680 hasConcept C139066938 @default.
- W2088891680 hasConcept C143425029 @default.
- W2088891680 hasConcept C160492267 @default.
- W2088891680 hasConcept C170734499 @default.
- W2088891680 hasConcept C185592680 @default.
- W2088891680 hasConcept C202751555 @default.
- W2088891680 hasConcept C2776818590 @default.
- W2088891680 hasConcept C2778004101 @default.
- W2088891680 hasConcept C2780829032 @default.
- W2088891680 hasConcept C552990157 @default.
- W2088891680 hasConcept C55493867 @default.
- W2088891680 hasConcept C556039675 @default.
- W2088891680 hasConcept C71924100 @default.
- W2088891680 hasConcept C86803240 @default.
- W2088891680 hasConcept C98274493 @default.
- W2088891680 hasConceptScore W2088891680C116073593 @default.
- W2088891680 hasConceptScore W2088891680C139066938 @default.
- W2088891680 hasConceptScore W2088891680C143425029 @default.
- W2088891680 hasConceptScore W2088891680C160492267 @default.
- W2088891680 hasConceptScore W2088891680C170734499 @default.
- W2088891680 hasConceptScore W2088891680C185592680 @default.
- W2088891680 hasConceptScore W2088891680C202751555 @default.
- W2088891680 hasConceptScore W2088891680C2776818590 @default.
- W2088891680 hasConceptScore W2088891680C2778004101 @default.
- W2088891680 hasConceptScore W2088891680C2780829032 @default.
- W2088891680 hasConceptScore W2088891680C552990157 @default.
- W2088891680 hasConceptScore W2088891680C55493867 @default.
- W2088891680 hasConceptScore W2088891680C556039675 @default.
- W2088891680 hasConceptScore W2088891680C71924100 @default.
- W2088891680 hasConceptScore W2088891680C86803240 @default.
- W2088891680 hasConceptScore W2088891680C98274493 @default.
- W2088891680 hasIssue "6" @default.
- W2088891680 hasLocation W20888916801 @default.
- W2088891680 hasOpenAccess W2088891680 @default.
- W2088891680 hasPrimaryLocation W20888916801 @default.
- W2088891680 hasRelatedWork W2340650634 @default.
- W2088891680 hasRelatedWork W2971415185 @default.
- W2088891680 hasRelatedWork W3082732637 @default.
- W2088891680 hasRelatedWork W3082957604 @default.
- W2088891680 hasRelatedWork W2610894099 @default.
- W2088891680 hasRelatedWork W2901101174 @default.
- W2088891680 hasRelatedWork W2901662617 @default.
- W2088891680 hasRelatedWork W2902150488 @default.
- W2088891680 hasRelatedWork W2960881098 @default.
- W2088891680 hasRelatedWork W2965567764 @default.
- W2088891680 hasVolume "6" @default.
- W2088891680 isParatext "false" @default.
- W2088891680 isRetracted "false" @default.
- W2088891680 magId "2088891680" @default.
- W2088891680 workType "article" @default.